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Treponema

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Molecular Typing in Bacterial Infections, Volume I

Abstract

The genus Treponema comprises a diverse group of bacteria with some well-known human pathogens including the causative agents of venereal syphilis (Treponema pallidum subspecies pallidum), yaws (T. pallidum subsp. pertenue), bejel or endemic syphilis (T. pallidum subsp. endemicum), and pinta (Treponema carateum). This chapter provides an update on genotyping and next-generation sequencing tools being used to study the molecular epidemiology and phylogenetics of T. pallidum. Diagnostic tests in use for syphilis and endemic treponematoses are also described. The enhanced Centers for Disease Control and Prevention typing (ECDCT) method has been applied to syphilis over the past two decades and more recently shown to be applicable to yaws; however, newer methods such as multilocus sequence typing (MLST) and whole genome sequencing (WGS) are being implemented for molecular epidemiological studies.

The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the Centers for Disease Control and Prevention.

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  1. Centers for Disease Control and Prevention, Division of STD Prevention, STD Laboratory Reference & Research Branch, Atlanta, GA, USA

    Mayur Shukla, Lara Pereira & Allan Pillay

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  2. Lara Pereira
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    Ivano de Filippis

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Shukla, M., Pereira, L., Pillay, A. (2022). Treponema . In: de Filippis, I. (eds) Molecular Typing in Bacterial Infections, Volume I. Springer, Cham. https://doi.org/10.1007/978-3-030-74018-4_9

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