Abstract
From the time the constellation of impairments associated with prenatal alcohol exposure was first described in the medical literature as fetal alcohol syndrome (FAS) in 1973, science has refined our understanding of the physical and behavioral signs and symptoms of this brain-based disorder and the consequences for affected individuals through the lifespan. Although phenotype variability remains in medical and behavioral health diagnostic guidelines, it generally is understood that the disability, now generally called fetal alcohol spectrum disorder (FASD), is a multisystem condition that involves the entire body, with the most common and significant impairments related to structural and functional brain damage. Despite its significance as the leading preventable nonhereditary cause of developmental disabilities, affecting as many as one in 20 school-age children in the United States, complex clinical and societal factors contribute to inadequate diagnostic capacity and limited awareness of FASD from the classroom to the courtroom. Systemic ignorance of FASD compounds the untreated progression of disabilities inherent in the disorder and underlies discriminatory treatment of individuals vulnerable to mental and substance use disorders and victimization, who lack accountability beyond their cognitive capacity. This chapter describes an evolution in our understanding of FASD and the models developed to clinically identify the disability. An increase in diagnostic accuracy is noted as well as a need for expanded research and scientific translation. Corresponding advances are essential in recognizing FASD across systems of care and non-medical settings to increase attention to and investment in the disorders, so affected children and adults achieve the outcomes and equitable treatment they deserve.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
American Academy of Pediatrics. (2013). American Academy of Pediatrics AAP FASD Toolkit. https://www.aap.org/en-us/advocacy-and-policy/aap-health-initiatives/fetal-alcohol-spectrum-disorders-toolkit/Pages/default.aspx
American Bar Association. (2012). FASD resolution and report. https://www.americanbar.org/groups/public_interest/child_law/resources/attorneys/fasd-resolution/
American Psychiatric Association (APA). (2013). Diagnostic and statistical manual of mental disorders (DSM-5) (5th ed.). Arlington, VA: American Psychiatric Association.
Astley, S. J. (2004). Diagnostic guide for fetal alcohol spectrum disorders: The 4-digit diagnostic code (3rd ed.). Seattle: University of Washington.
Astley, S. J. (2013). Validation of the fetal alcohol spectrum disorder (FASD) 4-digit diagnostic code. Journal of Population Therapeutics and Clinical Pharmacology, 20(3), e416–e467.
Atkins v. Virginia. (2002). 536 U.S. 304.
Benz, J., Rasmussen, C., & Andrew, G. (2009). Diagnosing fetal alcohol spectrum disorder: History, challenges and future directions. Pediatrics & Child Health, 14(4), 231–237. https://doi.org/10.1093/pch/14.4.231
Bertrand, J., Floyd, R. L., Weber, M. K., O’Connor, M. J., Riley, E. P., Johnson, K. A., … with National Task Force on Fetal Alcohol Syndrome and Fetal Alcohol Effect. (2004). Fetal alcohol syndrome: Guidelines for referral and diagnosis. Atlanta, GA: Centers for Disease Control and Prevention.
Breit, K. R., Zamudio, B., & Thomas, J. D. (2019). The effects of alcohol and cannabinoid exposure during the brain growth spurt on behavioral development in rats. Birth Defects Research, 111(12), 760–774. https://doi.org/10.1002/bdr2.1487
Brown, J. M., Haun, J., Zapf, P. A., & Novick Brown, N. (2017). Fetal alcohol spectrum disorders (FASD) and competency to stand trial (CST): Suggestions for a “best practices” approach to forensic evaluation. International Journal of Law and Psychiatry, 52, 19–27. https://doi.org/10.1016/j.ijlp.2017.04.002
Burd, L. (2016). Fetal alcohol spectrum disorder: Complexity from comorbidity. Lancet, 387, 926–927. https://doi.org/10.1016/s0140-6736(15)01346-x
Burd, L., Klug, M. G., Coumbe, M. J., & Kerbeshian, J. (2003). Children and adolescents with attention deficit-hyperactivity disorder: 1. Prevalence and cost of care. Journal of Child Neurology, 18(8), 555–561. https://doi.org/10.1177/08830738030180080101
Burd, L., Selfridge, R., Klug, M., & Bakko, S. (2004). Fetal alcohol syndrome in the United States corrections system. Addiction Biology, 9(2), 169–176. https://doi.org/10.1080/13556210410001717060
Calhoun, F., & Warren, K. R. (2007). Fetal alcohol syndrome: Historical perspectives. Neuroscience and Biobehavioral Reviews, 31(2), 168–171. https://doi.org/10.1016/j.neubiorev.2006.06.023
Charness, M. E., Riley, E. P., & Sowell, E. R. (2016). Drinking during pregnancy and the developing brain: Is any amount safe? Trends in Cognitive Sciences, 20(2), P80–P82. https://doi.org/10.1016/j.tics.2015.09.011
Chasnoff, I. J., Wells, A. M., & King, L. (2015). Misdiagnosis and missed diagnoses in foster and adopted children with prenatal alcohol exposure. Pediatrics, 135(2), 264–270. https://doi.org/10.1542/peds.2014-2171
Chudley, A. E., Kilgour, A. R., Cranston, M., & Edwards, M. (2007). Challenges of diagnosis in fetal alcohol syndrome and fetal alcohol spectrum disorder in the adult. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 145C(3), 261–272. https://doi.org/10.1002/ajmg.c.30140
Clarren, S. K., & Smith, D. W. (1978). The fetal alcohol syndrome. New England Journal of Medicine, 298(19), 1063–1067. https://doi.org/10.1056/nejm197805112981906
Connor, P. D., Sampson, P. D., Bookstein, F. L., Barr, H. M., & Streissguth, A. P. (2000). Direct and indirect effects of prenatal alcohol damage on executive function. Developmental Neuropsychology, 18(3), 331–354. https://doi.org/10.1207/S1532694204Connor
Cook, J. L., Green, C. R., Lilley, C. M., Anderson, S. M., Baldwin, M. E., Chudley, A. E., … Rosales, T. (2016). Fetal alcohol spectrum disorder: A guideline for diagnosis across the lifespan. CMAJ: Canadian Medical Association Journal, 188(3), 191–197. https://doi.org/10.1503/cmaj.141593
Corrigan, P. W., Lara, J. L., Shah, B. B., Mitchell, K. T., Simmes, D., & Jones, K. L. (2017). The public stigma of birth mothers of children with fetal alcohol spectrum disorders. Alcoholism: Clinical and Experimental Research, 41(6), 1166–1173. https://doi.org/10.1111/acer.13381
Crocker, N., Vaurio, L., Riley, E. P., & Mattson, S. N. (2009). Comparison of adaptive behavior in children with heavy prenatal alcohol exposure or attention-deficit/hyperactivity disorder. Alcoholism: Clinical and Experimental Research, 33(11), 2015–2023. https://doi.org/10.1111/j.1530-0277.2009.01040.x
Davis, P. J., Partridge, J. W., & Storrs, C. N. (1982). Alcohol consumption in pregnancy. How much is safe? Archives of Disease in Childhood, 57(12), 940–943. https://doi.org/10.1136/adc.57.12.940
Denny, C. H., Acero, C. S., Naimi, T. S., & Kim, S. Y. (2019). Consumption of alcohol beverages and binge drinking among pregnant women aged 18-44 years—United States, 2015-2017. Morbidity and Mortality Weekly Report (MMWR), 68(16), 365–368. https://doi.org/10.15585/mmwr.mm6816a1
Doyle, L. R., & Mattson, S. N. (2015). Neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE): Review of evidence and guidelines for assessment. Current Developmental Disorders Reports, 2(3), 175–186. https://doi.org/10.1007/s40474-015-0054-6
Edwards, W. J., & Greenspan, S. (2010). Adaptive behavior and fetal alcohol spectrum disorders. Journal of Psychiatry & Law, 38(4), 419–447. https://doi.org/10.1177/009318531003800404
Elliott, L., Haddock, C. K., Campos, S., & Benoit, E. (2019). Polysubstance use patterns and novel synthetics: A cluster analysis from three U.S. cities. PLoS One, 14(12), e0225273. https://doi.org/10.1371/journal.pone.0225273
Fagerlund, Å., Autti-Rämö, I., Kalland, M., Santtila, P., Hoyme, H. E., Mattson, S. N., & Korkman, M. (2012). Adaptive behaviour in children and adolescents with foetal alcohol spectrum disorders: A comparison with specific learning disability and typical development. European Child & Adolescent Psychiatry, 21(4), 221–231. https://doi.org/10.1007/s00787-012-0256-y
Fast, D. K., & Conry, J. (2004). The challenge of fetal alcohol syndrome in the criminal legal system. Addiction Biology, 9(2), 161–166. https://doi.org/10.1080/13556210410001717042
Fast, D. K., Conry, J., & Loock, C. A. (1999). Identifying fetal alcohol syndrome among youth in the criminal justice system. Journal of Developmental & Behavioral Pediatrics, 20(5), 370–372. https://doi.org/10.1097/00004703-199910000-00012
Fish, E. W., Murdaugh, L. B., Zhang, C., Boschen, K. E., Boa-Amponsem, O., Mendoza-Romero, H. N., … Parnell, S. E. (2019). Cannabinoids exacerbate alcohol teratogenesis by a CB1-hedgehog interaction. Scientific Reports, 9, 16057. https://doi.org/10.1038/s41598-019-52336-w
Food and Drug Administration (FDA). (1981). Surgeon General’s advisory on alcohol and pregnancy. FDA Drug Bulletin, 11(2), 9–10. http://come-over.to/FAS/SurgeonGeneral.htm.
Forray, A., & Foster, D. (2015). Substance use in the perinatal period. Current Psychiatry Reports, 17, 91. https://doi.org/10.1007/s11920-015-0626-5
Gautam, P., Warner, T. D., Kan, E. C., & Sowell, E. R. (2015). Executive function and cortical thickness in youths prenatally exposed to cocaine, alcohol and tobacco. Developmental Cognitive Neuroscience, 16, 155–165. https://doi.org/10.1016/j.dcn.2015.01.010
Green, C. R., Mihic, A. M., Nikkel, S. M., Stade, B. C., Rasmussen, C., Munoz, D. P., & Reynolds, J. N. (2009). Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge neuropsychological tests automated battery (CANTAB). Journal of Child Psychology and Psychiatry, and Allied Disciplines, 50(6), 688–697. https://doi.org/10.1111/j.1469-7610.2008.01990.x
Greenmyer, J. R., Klug, M. G., Kambeitz, C., Popova, S., & Burd, L. (2018). A multicountry updated assessment of the economic impact of fetal alcohol spectrum disorder: Costs for children and adults. Journal of Addiction Medicine, 12(6), 466–473. https://doi.org/10.1097/adm.0000000000000438
Greenspan, S., Novick Brown, N., & Edwards, W. (2016). FASD and the concept of “intellectual disability equivalence”. In M. Nelson & M. Trussler (Eds.), Fetal alcohol spectrum disorders in adults: Ethical and legal perspectives (pp. 241–266). Amsterdam and New York: Springer.
Hagan, J. F., Jr., Balachova, T., Bertrand, J., Chasnoff, I., Dang, E., Fernandez-Baca, D., … on behalf of Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure Workgroup and American Academy of Pediatrics. (2016). Neurobehavioral disorder associated with prenatal alcohol exposure. Pediatrics, 138(4), e20151553. https://doi.org/10.1542/peds.2015-1553
Hoyme, H. E., Kalberg, W. O., Elliott, A. J., Blankenship, J., Buckley, D., Marais, A. S., … May, P. A. (2016). Updated clinical guidelines for diagnosing fetal alcohol spectrum disorders. Pediatrics, 138(2), e20154256. https://doi.org/10.1542/peds.2015-4256
Hoyme, H. E., May, P. A., Kalberg, W. O., Kodituwakku, P., Gossage, J. P., Trujillo, P. M., Buckley,. . . Robinson, L. K. (2005). A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: Clarification of the 1996 Institute of Medicine criteria. Pediatrics, 115(1), 39–47. doi:https://doi.org/10.1542/peds.2004-0259
Jarmasz, J. S., Basalah, D. A., Chudley, A. E., & Del Bigio, M. R. (2017). Human brain abnormalities associated with prenatal alcohol exposure and fetal alcohol spectrum disorder. Journal of Neuropathology & Experimental Neurology, 76(9), 813–833. https://doi.org/10.1093/jnen/nlx064
Johnson, S., Moyer, C. L., Klug, M. G., & Burd, L. (2018). Comparison of alcohol-related neurodevelopmental disorders and neurodevelopmental disorders associated with prenatal alcohol exposure diagnostic criteria. Journal of Developmental & Behavioral Pediatrics, 39(2), 163–167. https://doi.org/10.1097/dbp.0000000000000523
Jones, K. L., & Smith, D. W. (1973). Recognition of the fetal alcohol syndrome in early infancy. Lancet, 302(7836), 999–1001. https://doi.org/10.1016/s0140-6736(73)91092-1
Jones, K. L., Smith, D. W., Streissguth, A. P., & Myrianthopoulos, N. C. (1974). Outcome in offspring of chronic alcoholic women. Lancet, 1(7866), 1076–1078. https://doi.org/10.1016/s0140-6736(74)90555-8
Jones, K. L., Smith, D. W., Ulleland, C. N., & Streissguth, A. P. (1973). Pattern of malformation in offspring of chronic alcoholic mothers. Lancet, 1(7815), 1267–1271. https://doi.org/10.1016/s0140-6736(73)91291-9
Kable, J. A., O’Connor, M. J., Olson, H. C., Paley, B., Mattson, S. N., Anderson, S., & Riley, E. P. (2016). Neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE): Proposed DSM-5 diagnosis. Child Psychiatry and Human Development, 47, 335–346. https://doi.org/10.1007/s10578-015-0566-7
Kelly, S. J., Day, N., & Streissguth, A. P. (2000). Effects of prenatal alcohol exposure on social behavior in humans and other species. Neurotoxicology and Teratology, 22(2), 143–149. https://doi.org/10.1016/s0892-0362(99)00073-2
Lemoine, P., Harousseau, H., Borteyru, J. P., & Menuet, J. C. (1968). Les enfants des parents alcoholiques: Anomolies observees a propos de 127 cas (the children of alcoholic parents: Anomalies observed in 127 cases). Quest Medical, 25, 476–482.
Manning, M. A., & Hoyme, H. E. (2007). Fetal alcohol spectrum disorders: A practical clinical approach to diagnosis. Neuroscience & Biobehavioral Reviews, 31(2), 230–238. https://doi.org/10.1016/j.neubiorev.2006.06.016
Mansfield, M., & Luther, G. (2013). Fetal alcohol spectrum disorder: Can diminished responsibility diminish criminal behaviour? International Journal of Law and Psychiatry, 36(1), 46–54. https://doi.org/10.1016/j.ijlp.2012.11.007
Mattson, S. N., Bernes, G. A., & Doyle, L. R. (2019). Fetal alcohol spectrum disorders: A review of the neurobehavioral deficits associated with prenatal alcohol exposure. Alcoholism: Clinical and Experimental Research, 43(6), 1046–1062. https://doi.org/10.1111/acer.14040
May, P. A., Chambers, C. D., Kalberg, W. O., Zellner, J., Feldman, H., Buckley, . . . Hoyme, H. E. (2018). Prevalence of fetal alcohol spectrum disorders in 4 US communities. Journal of the American Medical Association, 319(5), 474–482. doi:https://doi.org/10.1001/jama.2017.21896
McLennan, J. D. (2015). Misattributions and potential consequences: The case of child mental health problems and fetal alcohol spectrum disorders. Canadian Journal of Psychiatry, 60(12), 587–590. https://doi.org/10.1177/070674371506001210
Moore, E. M., & Riley, E. P. (2015). What happens when children with fetal alcohol spectrum disorders become adults? Current Developmental Disorders Reports, 2(3), 219–227. https://doi.org/10.1007/s40474-015-0053-7
Olson, H. C. (2015). Advancing recognition of fetal alcohol spectrum disorders: The proposed DSM-5 diagnosis of “neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE).”. Current Developmental Disorders Report, 2(3), 187–198. https://doi.org/10.1007/s40474-015-0056-4
Popova, S., Lange, S., Shield, K., Mihic, A., Chudley, A. E., Mukherjee, R. A. S., … Rehm, J. (2016). Comorbidity of fetal alcohol spectrum disorder: A systematic review and meta-analysis. Lancet, 387(10022), 978–987. https://doi.org/10.1016/s0140-6736(15)01345-8
Rosett, H. L. (1980). A clinical perspective of the fetal alcohol syndrome. Alcoholism: Clinical and Experimental Research, 4(2), 119–122. https://doi.org/10.1111/j.1530-0277.1980.tb05626.x
Ross, E. J., Graham, D. L., Money, K. M., & Stanwood, G. D. (2015). Developmental consequences of fetal exposure to drugs: What we know and what we still must learn. Neuropsychopharmacology, 40, 61–87. https://doi.org/10.1038/npp.2014.147
Scott-Goodwin, A. C., Puerto, M., & Moreno, I. (2016). Toxic effects of prenatal exposure to alcohol, tobacco and other drugs. Reproductive Toxicology (Elmsford, NY), 61, 120–130. https://doi.org/10.1016/j.reprotox.2016.03.043
Shuman, D. W., & Gold, L. H. (2008). Without thinking: Impulsive aggression and criminal responsibility. Behavioral Sciences & the Law, 26(6), 723–734. https://doi.org/10.1002/bsl.847
Stratton, K., Howe, C., & Battaglia, F. (Eds.). (1996). Fetal alcohol syndrome: Diagnosis, epidemiology, prevention, and treatment. Washington, DC: National Academy Press.
Streissguth, A. P. (1997). Fetal alcohol syndrome: A guide for families and communities. Baltimore, MD: Brookes.
Streissguth, A. P., Barr, H. M., Kogan, J., & Bookstein, F. L. (1996). Understanding the occurrence of secondary disabilities in clients with fetal alcohol syndrome (FAS) and fetal alcohol effects (FAE): Final report. Seattle: University of Washington. http://lib.adai.uw.edu/pubs/bk2698.pdf.
Streissguth, A. P., Bookstein, F. L., Barr, H. M., Sampson, P. D., O’Malley, K., & Young, J. K. (2004). Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects. Journal of Developmental and Behavioral Pediatrics (JDBP), 25(4), 228–238. https://doi.org/10.1097/00004703-200408000-00002
U.S. Department of Health and Human Services (HHS). (2005). U. S. Surgeon General releases advisory on alcohol use in pregnancy. Washington, DC: US Department of Health and Human Services. https://wayback.archive-it.org/3926/20140421162517/http://www.surgeongeneral.gov/news/2005/02/sg02222005.html#
Wozniak, J. R., Riley, E. P., & Charness, M. E. (2019). Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder. Lancet Neurology, 18(8), 760–770. https://doi.org/10.1016/s1474-4422(19)30150-4
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Donaldson, T. (2021). Diagnostic History: Prenatal Exposure to Alcohol and Other Teratogens. In: Novick Brown, N. (eds) Evaluating Fetal Alcohol Spectrum Disorders in the Forensic Context. Springer, Cham. https://doi.org/10.1007/978-3-030-73628-6_1
Download citation
DOI: https://doi.org/10.1007/978-3-030-73628-6_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-73627-9
Online ISBN: 978-3-030-73628-6
eBook Packages: Behavioral Science and PsychologyBehavioral Science and Psychology (R0)