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Human Embryonic Stem Cell Banking for Clinical Applications—20 Years from Their Isolation

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Essentials of Tissue and Cells Banking

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Abstract

Twenty years on from the first reported isolation of pluripotent human embryonic stem cells (hESC) from in vitro fertilised preimplantation embryos, clinical evaluation of derivative cell products is ongoing. Contrary to expectations that pluripotency induction by genetic reprogramming would replace commitment to hESC source material basic and translational research and application has continued. Here we update on current clinical, translational and scientific progress and issues in human embryonic stem cell banking. These reflect transformation of an academically lead research into quality assured good manufacturing practice grade cell banking underpinning active clinical investigations.

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Authors and Affiliations

  1. Centre for Clinical Brain Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, Scotland

    Paul A. De Sousa

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Correspondence to Paul A. De Sousa .

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  1. National Blood Transfusion Service, St. Luke’s Hospital, Pietà, Malta

    George Galea

  2. Scottish National Blood Transfusion Service, Edinburgh, UK

    Marc Turner

  3. Scottish National Blood Transfusion Service, Edinburgh, UK

    Sharon Zahra

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De Sousa, P.A. (2021). Human Embryonic Stem Cell Banking for Clinical Applications—20 Years from Their Isolation. In: Galea, G., Turner, M., Zahra, S. (eds) Essentials of Tissue and Cells Banking. Springer, Cham. https://doi.org/10.1007/978-3-030-71621-9_15

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