Skip to main content

Diagnostic Approach after Initial Abnormal Screening

  • Chapter
  • First Online:
Sports Cardiology
  • 576 Accesses

Abstract

The cardiac evaluation of an athlete begins with a history and physical examination and sometimes includes a 12-lead electrocardiogram (ECG), depending upon local or organizational policies and practices. An understanding of symptoms and physical exam findings that warrant further evaluation, plus knowledge of expected and abnormal ECG findings in athletes, is essential to determine when, and if, further and more detailed downstream cardiac testing is required. When imaging beyond an ECG is indicated and requested, this downstream testing can encompass numerous cardiac tests and visits to subspecialists that have the potential to incur significant cost, time, anxiety, and continued uncertainty. Fundamental downstream tests commonly requested and used in the cardiac evaluation of highly active individuals and competitive athletes include transthoracic echocardiograms, cardiac magnetic resonance imaging, coronary computed tomography angiography, and stress testing. Each of these tests has strengths and weaknesses in their ability to provide additive diagnostic information and to help distinguish physiologic athletic cardiac remodeling from potential underlying cardiac pathology. This chapter will focus on and outline how to best utilize multimodality imaging for the assessment of athletes who may present for an evaluation after a pre-participation screening exam, for athletes with new or evolving symptoms, for asymptomatic older athletes, and for younger athletes with congenital heart disease. A well-constructed plan for downstream testing can diagnose and risk stratify athletes in a streamlined fashion and limit unnecessary testing and expense while avoiding a prolonged return to play timeline.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Prior DL, La Gerche A. The athlete’s heart. Heart. 2012;98:947–55.

    Article  PubMed  Google Scholar 

  2. Astrand PO, Cuddy TE, Saltin B, Stenberg J. Cardiac output during submaximal and maximal work. J Appl Physiol. 1964;19:268–74.

    Article  CAS  PubMed  Google Scholar 

  3. Weiner RB, Wang F, Isaacs SK, Malhotra R, Berkstresser B, Kim JH, Hutter AM Jr, Picard MH, Wang TJ, Baggish AL. Blood pressure and left ventricular hypertrophy during American-style football participation. Circulation. 2013;128:524–31.

    Article  PubMed  Google Scholar 

  4. Baggish AL, Weiner RB, Kanayama G, Hudson JI, Lu MT, Hoffmann U, Pope HG Jr. Cardiovascular toxicity of illicit anabolic-androgenic steroid use. Circulation. 2017;135:1991–2002.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sharma S, Merghani A, Mont L. Exercise and the heart: the good, the bad, and the ugly. Eur Heart J. 2015;36:1445–53.

    Article  PubMed  Google Scholar 

  6. Whyte GP, George K, Nevill A, Shave R, Sharma S, McKenna WJ. Left ventricular morphology and function in female athletes: a meta-analysis. Int J Sports Med. 2004;25:380–3.

    Article  CAS  PubMed  Google Scholar 

  7. Sun B, Ma JZ, Yong YH, Lv YY. The upper limit of physiological cardiac hypertrophy in elite male and female athletes in China. Eur J Appl Physiol. 2007;101:457–63.

    Article  PubMed  Google Scholar 

  8. Whyte GP, George K, Sharma S, Firoozi S, Stephens N, Senior R, McKenna WJ. The upper limit of physiological cardiac hypertrophy in elite male and female athletes: the British experience. Eur J Appl Physiol. 2004;92:592–7.

    Article  CAS  PubMed  Google Scholar 

  9. Howden EJ, Perhonen M, Peshock RM, Zhang R, Arbab-Zadeh A, Adams-Huet B, Levine BD. Females have a blunted cardiovascular response to one year of intensive supervised endurance training. J Appl Physiol (1985). 2015;119:37–46.

    Article  Google Scholar 

  10. Weiner RB, DeLuca JR, Wang F, Lin J, Wasfy MM, Berkstresser B, Stöhr E, Shave R, Lewis GD, Hutter AM Jr, Picard MH, Baggish AL. Exercise-induced left ventricular remodeling among competitive athletes: a phasic phenomenon. Circ Cardiovasc Imaging. 2015;8:e003651.

    Article  PubMed  Google Scholar 

  11. Caruso MR, Garg L, Martinez MW. Cardiac imaging in the athlete: shrinking the “gray zone”. Curr Treat Options Cardiovasc Med. 2020;22:5.

    Article  PubMed  Google Scholar 

  12. Quarta G, Papadakis M, Donna PD, Maurizi N, Iacovoni A, Gavazzi A, Senni M, Olivotto I. Grey zones in cardiomyopathies: defining boundaries between genetic and iatrogenic disease. Nat Rev Cardiol. 2017;14:102–12.

    Article  CAS  PubMed  Google Scholar 

  13. Martinez MW. Advanced imaging of athletes: added value of coronary computed tomography and cardiac magnetic resonance imaging. Clin Sports Med. 2015;34:433–48.

    Article  PubMed  Google Scholar 

  14. Brosnan M, La Gerche A, Kalman J, Lo W, Fallon K, MacIsaac A, Prior DL. Comparison of frequency of significant electrocardiographic abnormalities in endurance versus nonendurance athletes. Am J Cardiol. 2014;113:1567–73.

    Article  PubMed  Google Scholar 

  15. Sharma S, Drezner JA, Baggish A, Papadakis M, Wilson MG, Prutkin JM, La Gerche A, Ackerman MJ, Borjesson M, Salerno JC, Asif IM, Owens DS, Chung EH, Emery MS, Froelicher VF, Heidbuchel H, Adamuz C, Asplund CA, Cohen G, Harmon KG, Marek JC, Molossi S, Niebauer J, Pelto HF, Perez MV, Riding NR, Saarel T, Schmied CM, Shipon DM, Stein R, Vetter VL, Pelliccia A, Corrado D. International recommendations for electrocardiographic interpretation in athletes. J Am Coll Cardiol. 2017;69:1057–75.

    Article  PubMed  Google Scholar 

  16. Pelliccia A, Maron BJ, Culasso F, Di Paolo FM, Spataro A, Biffi A, Caselli G, Piovano P. Clinical significance of abnormal electrocardiographic patterns in trained athletes. Circulation. 2000;102:278–84.

    Article  CAS  PubMed  Google Scholar 

  17. Papadakis M, Basavarajaiah S, Rawlins J, Edwards C, Makan J, Firoozi S, Carby L, Sharma S. Prevalence and significance of T-wave inversions in predominantly Caucasian adolescent athletes. Eur Heart J. 2009;30:1728–35.

    Article  PubMed  Google Scholar 

  18. Papadakis M, Carre F, Kervio G, Rawlins J, Panoulas VF, Chandra N, Basavarajaiah S, Carby L, Fonseca T, Sharma S. The prevalence, distribution, and clinical outcomes of electrocardiographic repolarization patterns in male athletes of African/Afro-Caribbean origin. Eur Heart J. 2011;32:2304–13.

    Article  PubMed  Google Scholar 

  19. Riding NR, Salah O, Sharma S, Carré F, George KP, Farooq A, Hamilton B, Chalabi H, Whyte GP, Wilson MG. ECG and morphologic adaptations in Arabic athletes: are the European Society of Cardiology’s recommendations for the interpretation of the 12-lead ECG appropriate for this ethnicity? Br J Sports Med. 2014;48:1138–43.

    Article  PubMed  Google Scholar 

  20. Sharma S, Whyte G, Elliott P, Padula M, Kaushal R, Mahon N, McKenna WJ. Electrocardiographic changes in 1000 highly trained junior elite athletes. Br J Sports Med. 1999;33:319–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Huston TP, Puffer JC, Rodney WM. The athletic heart syndrome. N Engl J Med. 1985;313:24–32.

    Article  CAS  PubMed  Google Scholar 

  22. Sheikh N, Papadakis M, Ghani S, Zaidi A, Gati S, Adami PE, Carré F, Schnell F, Wilson M, Avila P. Comparison of electrocardiographic criteria for the detection of cardiac abnormalities in elite black and white athletes. Circulation. 2014;129:1637–49.

    Article  PubMed  Google Scholar 

  23. Lakdawala NK, Thune JJ, Maron BJ, Cirino AL, Havndrup O, Bundgaard H, Christiansen M, Carlsen CM, Dorval J-F, Kwong RY. Electrocardiographic features of sarcomere mutation carriers with and without clinically overt hypertrophic cardiomyopathy. Am J Cardiol. 2011;108:1606–13.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Sheikh N, Papadakis M, Schnell F, Panoulas V, Malhotra A, Wilson M, Carré F, Sharma S. Clinical profile of athletes with hypertrophic cardiomyopathy. Circ Cardiovasc Imaging. 2015;8:e003454.

    Article  PubMed  Google Scholar 

  25. Calore C, Zorzi A, Sheikh N, Nese A, Facci M, Malhotra A, Zaidi A, Schiavon M, Pelliccia A, Sharma S. Electrocardiographic anterior T-wave inversion in athletes of different ethnicities: differential diagnosis between athlete’s heart and cardiomyopathy. Eur Heart J. 2016;37:2515–27.

    Article  PubMed  Google Scholar 

  26. Malhotra A, Dhutia H, Gati S, Yeo T-J, Dores H, Bastiaenen R, Narain R, Merghani A, Finocchiaro G, Sheikh N. Anterior T-wave inversion in young white athletes and nonathletes: prevalence and significance. J Am Coll Cardiol. 2017;69:1–9.

    Article  PubMed  Google Scholar 

  27. Chandra N, Bastiaenen R, Papadakis M, Panoulas VF, Ghani S, Duschl J, Foldes D, Raju H, Osborne R, Sharma S. Prevalence of electrocardiographic anomalies in young individuals: relevance to a nationwide cardiac screening program. J Am Coll Cardiol. 2014;63:2028–34.

    Article  PubMed  Google Scholar 

  28. Pelliccia A, Di Paolo FM, Quattrini FM, Basso C, Culasso F, Popoli G, De Luca R, Spataro A, Biffi A, Thiene G, Maron BJ. Outcomes in athletes with marked ECG repolarization abnormalities. N Engl J Med. 2008;358:152–61.

    Article  CAS  PubMed  Google Scholar 

  29. Schnell F, Riding N, O’Hanlon R, Axel Lentz P, Donal E, Kervio G, Matelot D, Leurent G, Doutreleau S, Chevalier L. Recognition and significance of pathological T-wave inversions in athletes. Circulation. 2015;131:165–73.

    Article  PubMed  Google Scholar 

  30. Bent RE, Wheeler MT, Hadley D, Knowles JW, Pavlovic A, Finocchiaro G, Haddad F, Salisbury H, Race S, Shmargad Y. Systematic comparison of digital electrocardiograms from healthy athletes and patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2015;65:2462–3.

    Article  PubMed  Google Scholar 

  31. Maron MS, Maron BJ, Harrigan C, Buros J, Gibson CM, Olivotto I, Biller L, Lesser JR, Udelson JE, Manning WJ. Hypertrophic cardiomyopathy phenotype revisited after 50 years with cardiovascular magnetic resonance. J Am Coll Cardiol. 2009;54:220–8.

    Article  PubMed  Google Scholar 

  32. Maron MS, Lesser JR, Maron BJ. Management implications of massive left ventricular hypertrophy in hypertrophic cardiomyopathy significantly underestimated by echocardiography but identified by cardiovascular magnetic resonance. Am J Cardiol. 2010;105:1842–3.

    Article  PubMed  Google Scholar 

  33. Nagueh SF, Bierig SM, Budoff MJ, Desai M, Dilsizian V, Eidem B, Goldstein SA, Hung J, Maron MS, Ommen SR, Woo A. American Society of Echocardiography clinical recommendations for multimodality cardiovascular imaging of patients with hypertrophic cardiomyopathy: endorsed by the American Society of Nuclear Cardiology, Society for Cardiovascular Magnetic Resonance, and Society of Cardiovascular Computed Tomography. J Am Soc Echocardiogr. 2011;24:473–98.

    Article  PubMed  Google Scholar 

  34. Rickers C, Wilke NM, Jerosch-Herold M, Casey SA, Panse P, Panse N, Weil J, Zenovich AG, Maron BJ. Utility of cardiac magnetic resonance imaging in the diagnosis of hypertrophic cardiomyopathy. Circulation. 2005;112:855–61.

    Article  PubMed  Google Scholar 

  35. Link MS, Laidlaw D, Polonsky B, Zareba W, McNitt S, Gear K, Marcus F, Estes NM. Ventricular arrhythmias in the North American multidisciplinary study of ARVC: predictors, characteristics, and treatment. J Am Coll Cardiol. 2014;64:119–25.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Circulation. 2010;121:1533–41.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Nasir K, Bomma C, Tandri H, Roguin A, Dalal D, Prakasa K, Tichnell C, James C, Jspevak P, Marcus F. Electrocardiographic features of arrhythmogenic right ventricular dysplasia/cardiomyopathy according to disease severity: a need to broaden diagnostic criteria. Circulation. 2004;110:1527–34.

    Article  PubMed  Google Scholar 

  38. Saguner AM, Ganahl S, Kraus A, Baldinger SH, Akdis D, Saguner AR, Wolber T, Haegeli LM, Steffel J, Krasniqi N. Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia. BMC Cardiovasc Disord. 2015;15:4.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Prior D. Differentiating athlete’s heart from cardiomyopathies – the right side. Heart Lung Circ. 2018;27:1063–71.

    Google Scholar 

  40. members ATF, Elliott PM, Anastasakis A, Borger MA, Borggrefe M, Cecchi F, Charron P, Hagege AA, Lafont A, Limongelli G. 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the task force for the diagnosis and management of hypertrophic cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J. 2014;35:2733–79.

    Article  Google Scholar 

  41. Di Paolo FM, Schmied C, Zerguini YA, Junge A, Quattrini F, Culasso F, Dvorak J, Pelliccia A. The athlete’s heart in adolescent Africans: an electrocardiographic and echocardiographic study. J Am Coll Cardiol. 2012;59:1029–36.

    Article  PubMed  Google Scholar 

  42. Baggish AL, Hutter AM, Wang F, Yared K, Weiner RB, Kupperman E, Picard MH, Wood MJ. Cardiovascular screening in college athletes with and without electrocardiography: a cross-sectional study. Ann Intern Med. 2010;152:269–75.

    Article  PubMed  Google Scholar 

  43. Haghjoo M, Mohammadzadeh S, Taherpour M, Faghfurian B, Fazelifar AF, Alizadeh A, Rad MA, Sadr-Ameli MA. ST-segment depression as a risk factor in hypertrophic cardiomyopathy. Europace. 2009;11:643–9.

    Article  PubMed  Google Scholar 

  44. Maron BJ, Wolfson JK, Ciró E, Spirito P. Relation of electrocardiographic abnormalities and patterns of left ventricular hypertrophy identified by 2-dimensional echocardiography in patients with hypertrophic cardiomyopathy. Am J Cardiol. 1983;51:189–94.

    Article  CAS  PubMed  Google Scholar 

  45. Etheridge SP, Escudero CA, Blaufox AD, Law IH, Dechert-Crooks BE, Stephenson EA, Dubin AM, Ceresnak SR, Motonaga KS, Skinner JR, Marcondes LD, Perry JC, Collins KK, Seslar SP, Cabrera M, Uzun O, Cannon BC, Aziz PF, Kubuš P, Tanel RE, Valdes SO, Sami S, Kertesz NJ, Maldonado J, Erickson C, Moore JP, Asakai H, Mill L, Abcede M, Spector ZZ, Menon S, Shwayder M, Bradley DJ, Cohen MI, Sanatani S. Life-threatening event risk in children with Wolff-Parkinson-White syndrome: a multicenter international study. JACC Clin Electrophysiol. 2018;4:433–44.

    Article  PubMed  Google Scholar 

  46. Cohen M, Triedman J, Cannon B, Davis A, Drago F, Janousek J, Klein G, Law I, Morady F, Paul T. Pediatric and Congenital Electrophysiology Society (PACES). Heart Rhythm Society (HRS). 2012;9(6):1006–24.

    Google Scholar 

  47. Daubert C, Ollitrault J, Descaves C, Mabo P, Ritter P, Gouffalt J. Failure of the exercise test to predict the anterograde refractory period of the accessory pathway in Wolff Parkinson White syndrome. Pacing Clin Electrophysiol. 1988;11:1130–8.

    Article  CAS  PubMed  Google Scholar 

  48. Roberts WC, Grayburn PA, Hall SA. Complications of radiofrequency ablation for supraventricular tachycardia in the Wolff-Parkinson-White syndrome associated with noncompaction cardiomyopathy. Am J Cardiol. 2018;121:1442–4.

    Article  PubMed  Google Scholar 

  49. Marek J, Bufalino V, Davis J, Marek K, Gami A, Stephan W, Zimmerman F. Feasibility and findings of large-scale electrocardiographic screening in young adults: data from 32,561 subjects. Heart Rhythm. 2011;8:1555–9.

    Article  PubMed  Google Scholar 

  50. Kim JH, Baggish AL. Electrocardiographic right and left bundle branch block patterns in athletes: prevalence, pathology, and clinical significance. J Electrocardiol. 2015;48:380–4.

    Article  PubMed  Google Scholar 

  51. Le V-V, Wheeler MT, Mandic S, Dewey F, Fonda H, Perez M, Sungar G, Garza D, Ashley EA, Matheson G. Addition of the electrocardiogram to the preparticipation examination of college athletes. Clin J Sport Med. 2010;20:98–105.

    Article  PubMed  Google Scholar 

  52. Platonov PG, Calkins H, Hauer RN, Corrado D, Svendsen JH, Wichter T, Biernacka EK, Saguner AM, Te Riele AS, Zareba W. High interobserver variability in the assessment of epsilon waves: implications for diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia. Heart Rhythm. 2016;13:208–16.

    Article  PubMed  Google Scholar 

  53. Kirchhof P, Fabritz L, Zwiener M, Witt H, Schafers M, Zellerhoff S, Paul M, Athai T, Hiller KH, Baba HA, Breithardt G, Ruiz P, Wichter T, Levkau B. Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice. Circulation. 2006;114:1799–806.

    Article  PubMed  Google Scholar 

  54. Zaidi A, Sheikh N, Jongman JK, Gati S, Panoulas VF, Carr-White G, Papadakis M, Sharma R, Behr ER, Sharma S. Clinical differentiation between physiological remodeling and arrhythmogenic right ventricular cardiomyopathy in athletes with marked electrocardiographic repolarization anomalies. J Am Coll Cardiol. 2015;65:2702–11.

    Article  PubMed  Google Scholar 

  55. Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria. Eur Heart J. 2010;31:806–14.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Baggish AL, Battle RW, Beckerman JG, Bove AA, Lampert RJ, Levine BD, Link MS, Martinez MW, Molossi SM, Salerno J, Wasfy MM, Weiner RB, Emery MS. Sports cardiology: core curriculum for providing cardiovascular care to competitive athletes and highly active people. J Am Coll Cardiol. 2017;70:1902–18.

    Article  PubMed  Google Scholar 

  57. Singh AM, McGregor RS. Differential diagnosis of chest symptoms in the athlete. Clin Rev Allergy Immunol. 2005;29:87–96.

    Article  PubMed  Google Scholar 

  58. Churchill TW, Disanto M, Singh TK, Groezinger E, Loomer G, Contursi M, DiCarli M, Michaud-Finch J, Stewart KM, Hutter AM, Lewis GD, Weiner RB, Baggish AL, Wasfy MM. Diagnostic yield of customized exercise provocation following routine testing. Am J Cardiol. 2019;123:2044–50.

    Article  PubMed  Google Scholar 

  59. Moya A, Sutton R, Ammirati F, Blanc JJ, Brignole M, Dahm JB, Deharo JC, Gajek J, Gjesdal K, Krahn A, Massin M, Pepi M, Pezawas T, Ruiz Granell R, Sarasin F, Ungar A, van Dijk JG, Walma EP, Wieling W. Guidelines for the diagnosis and management of syncope (version 2009). Eur Heart J. 2009;30:2631–71.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Colivicchi F, Ammirati F, Biffi A, Verdile L, Pelliccia A, Santini M. Exercise-related syncope in young competitive athletes without evidence of structural heart disease. Clinical presentation and long-term outcome. Eur Heart J. 2002;23:1125–30.

    Article  CAS  PubMed  Google Scholar 

  61. Shen WK, Sheldon RS, Benditt DG, Cohen MI, Forman DE, Goldberger ZD, Grubb BP, Hamdan MH, Krahn AD, Link MS, Olshansky B, Raj SR, Sandhu RK, Sorajja D, Sun BC, Yancy CW. 2017 ACC/AHA/HRS Guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines and the Heart Rhythm Society. Circulation. 2017;136:e60–e122.

    PubMed  Google Scholar 

  62. Qureshi MY, O’Leary PW, Connolly HM. Cardiac imaging in Ebstein anomaly. Trends Cardiovasc Med. 2018;28:403–9.

    Article  PubMed  Google Scholar 

  63. Porto AG, Brun F, Severini GM, Losurdo P, Fabris E, Taylor MRG, Mestroni L, Sinagra G. Clinical spectrum of PRKAG2 syndrome. Circ Arrhythm Electrophysiol. 2016;9:e003121.

    Article  PubMed  Google Scholar 

  64. Schwartz PJ, Ackerman MJ, Wilde AAM. Channelopathies as causes of sudden cardiac death. Card Electrophysiol Clin. 2017;9:537–49.

    Article  PubMed  Google Scholar 

  65. Ackerman MJ, Priori SG, Willems S, Berul C, Brugada R, Calkins H, Camm AJ, Ellinor PT, Gollob M, Hamilton R, Hershberger RE, Judge DP, Le Marec H, WJ MK, Schulze-Bahr E, Semsarian C, Towbin JA, Watkins H, Wilde A, Wolpert C, Zipes DP. HRS/EHRA Expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Heart Rhythm. 2011;8:1308–39.

    Article  PubMed  Google Scholar 

  66. Turagam MK, Velagapudi P, Kocheril AG. Atrial fibrillation in athletes. Am J Cardiol. 2012;109:296–302.

    Article  PubMed  Google Scholar 

  67. Boraita A, Santos-Lozano A, Heras ME, González-Amigo F, López-Ortiz S, Villacastín JP, Lucia A. Incidence of atrial fibrillation in elite athletes. JAMA Cardiol. 2018;3:1200–5.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Furlanello F, Bertoldi A, Dallago M, Galassi A, Fernando F, Biffi A, Mazzone P, Pappone C, Chierchia S. Atrial fibrillation in elite athletes. J Cardiovasc Electrophysiol. 1998;9:S63–8.

    CAS  PubMed  Google Scholar 

  69. Lai E, Chung EH. Management of arrhythmias in athletes: atrial fibrillation, premature ventricular contractions, and ventricular tachycardia. Curr Treat Options Cardiovasc Med. 2017;19:86.

    Article  PubMed  Google Scholar 

  70. Zipes DP, Link MS, Ackerman MJ, Kovacs RJ, Myerburg RJ, Estes NAM 3rd. Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 9: arrhythmias and conduction defects: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol. 2015;66:2412–23.

    Article  PubMed  Google Scholar 

  71. Parshall MB, Schwartzstein RM, Adams L, Banzett RB, Manning HL, Bourbeau J, Calverley PM, Gift AG, Harver A, Lareau SC, Mahler DA, Meek PM, O’Donnell DE. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med. 2012;185:435–52.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Boulet LP. Cough and upper airway disorders in elite athletes: a critical review. Br J Sports Med. 2012;46:417–21.

    Article  PubMed  Google Scholar 

  73. Tilles SA. Exercise-induced airway dysfunction in athletes. Immunol Allergy Clin N Am. 2018;38:xiii–xiv.

    Google Scholar 

  74. Boulet LP, Turmel J, Côté A. Asthma and exercise-induced respiratory symptoms in the athlete: new insights. Curr Opin Pulm Med. 2017;23:71–7.

    Article  CAS  PubMed  Google Scholar 

  75. Sarma S, Levine BD. Beyond the Bruce protocol: advanced exercise testing for the sports cardiologist. Cardiol Clin. 2016;34:603–8.

    Article  PubMed  Google Scholar 

  76. Watson AM. Sleep and athletic performance. Curr Sports Med Rep. 2017;16:413–8.

    Article  PubMed  Google Scholar 

  77. Meeusen R, Duclos M, Foster C, Fry A, Gleeson M, Nieman D, Raglin J, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine. Med Sci Sports Exerc. 2013;45:186–205.

    Article  PubMed  Google Scholar 

  78. Goel R, Majeed F, Vogel R, Corretti MC, Weir M, Mangano C, White C, Plotnick GD, Miller M. Exercise-induced hypertension, endothelial dysfunction, and coronary artery disease in a marathon runner. Am J Cardiol. 2007;99:743–4.

    Article  PubMed  Google Scholar 

  79. Möhlenkamp S, Lehmann N, Breuckmann F, Bröcker-Preuss M, Nassenstein K, Halle M, Budde T, Mann K, Barkhausen J, Heusch G, Jöckel KH, Erbel R. Running: the risk of coronary events: prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. Eur Heart J. 2008;29:1903–10.

    Article  PubMed  Google Scholar 

  80. Merghani A, Maestrini V, Rosmini S, Cox AT, Dhutia H, Bastiaenan R, David S, Yeo TJ, Narain R, Malhotra A, Papadakis M, Wilson MG, Tome M, AlFakih K, Moon JC, Sharma S. Prevalence of subclinical coronary artery disease in masters endurance athletes with a low atherosclerotic risk profile. Circulation. 2017;136:126–37.

    Article  CAS  PubMed  Google Scholar 

  81. DeFina LF, Radford NB, Barlow CE, Willis BL, Leonard D, Haskell WL, Farrell SW, Pavlovic A, Abel K, Berry JD, Khera A, Levine BD. Association of all-cause and cardiovascular mortality with high levels of physical activity and concurrent coronary artery calcification. JAMA Cardiol. 2019;4:174–81.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Budoff MJ, Mayrhofer T, Ferencik M, Bittner D, Lee KL, Lu MT, Coles A, Jang J, Krishnam M, Douglas PS, Hoffmann U. Prognostic value of coronary artery calcium in the PROMISE study (Prospective multicenter imaging study for evaluation of chest pain). Circulation. 2017;136:1993–2005.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Radford NB, DeFina LF, Barlow CE, Lakoski SG, Leonard D, Paixao AR, Khera A, Levine BD. Progression of CAC score and risk of incident CVD. JACC Cardiovasc Imaging. 2016;9:1420–9.

    Article  PubMed  Google Scholar 

  84. Ekblom-Bak E, Ekblom Ö, Fagman E, Angerås O, Schmidt C, Rosengren A, Börjesson M, Bergström G. Fitness attenuates the prevalence of increased coronary artery calcium in individuals with metabolic syndrome. Eur J Prev Cardiol. 2018;25:309–16.

    Article  PubMed  Google Scholar 

  85. Wilhelm M, Roten L, Tanner H, Schmid JP, Wilhelm I, Saner H. Long-term cardiac remodeling and arrhythmias in nonelite marathon runners. Am J Cardiol. 2012;110:129–35.

    Article  PubMed  Google Scholar 

  86. Andersen K, Farahmand B, Ahlbom A, Held C, Ljunghall S, Michaëlsson K, Sundström J. Risk of arrhythmias in 52 755 long-distance cross-country skiers: a cohort study. Eur Heart J. 2013;34:3624–31.

    Article  PubMed  Google Scholar 

  87. Dean PN, Battle RW. Congenital heart disease and the athlete: what we know and what we do not know. Cardiol Clin. 2016;34:579–89.

    Article  PubMed  Google Scholar 

  88. Etheridge SP, Saarel EV, Martinez MW. Exercise participation and shared decision-making in patients with inherited channelopathies and cardiomyopathies. Heart Rhythm. 2018;15:915–20.

    Article  PubMed  Google Scholar 

  89. Van Hare GF, Ackerman MJ, Evangelista JA, Kovacs RJ, Myerburg RJ, Shafer KM, Warnes CA, Washington RL. Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 4: congenital heart disease: a scientific statement from the American Heart Association and American College of Cardiology. Circulation. 2015;132:e281–91.

    PubMed  Google Scholar 

  90. Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, Kirchhof P, Kjeldsen K, Kuck KH, Hernandez-Madrid A, Nikolaou N, Norekvål TM, Spaulding C, Van Veldhuisen DJ. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015;36:2793–867.

    Article  PubMed  Google Scholar 

  91. McKillop A, McCrindle BW, Dimitropoulos G, Kovacs AH. Physical activity perceptions and behaviors among young adults with congenital heart disease: a mixed-methods study. Congenit Heart Dis. 2018;13:232–40.

    Article  PubMed  Google Scholar 

  92. Cohen MS, Eidem BW, Cetta F, Fogel MA, Frommelt PC, Ganame J, Han BK, Kimball TR, Johnson RK, Mertens L, Paridon SM, Powell AJ, Lopez L. Multimodality imaging guidelines of patients with transposition of the great arteries: a report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography. J Am Soc Echocardiogr. 2016;29:571–621.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Matthew W. Martinez .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Martinez, M.W. (2021). Diagnostic Approach after Initial Abnormal Screening. In: Engel, D.J., Phelan, D.M. (eds) Sports Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-69384-8_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-69384-8_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-69383-1

  • Online ISBN: 978-3-030-69384-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics