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Use of FDM Technology in Healthcare Applications: Recent Advances

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Fused Deposition Modeling Based 3D Printing

Part of the book series: Materials Forming, Machining and Tribology ((MFMT))

Abstract

Additive Manufacturing (AM) technologies, which were developed around 30 years ago, are still evolving. They are applied in different sectors such as aeronautics, automotive, health, etc. There are different AM technologies: binder jetting, direct energy deposition, material extrusion, material jetting, powder bed fusion, sheet lamination and vat photopolimerisation. Amongst all of them, material extrusion is the most common technique used nowadays, due to several reasons: manufacture of parts is easy and cost-effective, desktop 3D printers are affordable, and they allow the use of many different materials. Within this AM category, two main techniques can be highlighted: FFF (Fused Filament Fabrication), also known as FDM (Fused Deposition Modelling), and DIW (Direct Ink Writing). FFF is the most typical technology which can offer multimaterial 3D printed parts. In addition, it can be mixed with other AM technologies in order to build hybrid 3D printers. Main applications of the FFF technology in the medical sector, which are explained in detail in the present chapter, are the manufacture of training models and surgical planning prototypes, medical devices, surgical guides, bio-active scaffolds, and cell 3D-bioprinting, etc. During the global pandemic of COVID-19, the FDM technology allowed to print different devices such as face masks or artificial breathers, among others.

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References

  1. ISO/ASTM (2015) International Standard ISO/ ASTM 52900 Additive manufacturing—general principles—Terminology. Int Organ Stand. https://doi.org/10.1520/ISOASTM52900-15

    Article  Google Scholar 

  2. Scott Crump S, Minnetonka M (1989) Apparatus and method for creating three-dimensional objects, 15. US5121329A

    Google Scholar 

  3. Gibson I, Rosen DW, Stucker B (2010) Additive manufacturing technologies. Springer, US, Boston, MA

    Book  Google Scholar 

  4. Buj-Corral I, Domínguez-Fernández A, Gómez-Gejo A (2020) Effect of printing parameters on dimensional error and surface roughness obtained in direct ink writing (DIW) processes. Materials 13:2157.1–2157.11

    Google Scholar 

  5. Guzzi EA, Bovone G, Tibbitt MW (2019) Universal nanocarrier ink platform for biomaterials additive manufacturing. Small 15(51):1905421

    Article  Google Scholar 

  6. Boulaala M, Elmessaoudi D, Buj-Corral I et al (2020) Towards design of mechanical part and electronic control of multi-material/multicolor fused deposition modeling 3D printing. Int J Adv Manuf Technol 110:45–55

    Article  Google Scholar 

  7. Keller P (2016) Designing a compact dual head for FLM 3D printing technology. MM Sci J 2016:1560–1564

    Article  Google Scholar 

  8. Löffler R, Koch M (2019) Innovative extruder concept for fast and efficient additive manufacturing. In: IFAC-Papers OnLine, pp 242–247

    Google Scholar 

  9. Fenollosa-Artés F (2018) Contribució a l’estudi de la impressió 3D per a la fabricació de models per facilitar l’assaig d’operacions quirúrgiques de tumors—Contribution to the study of 3D printing for the manufacture of models to facilitate the testing of tumour surgery. PhD thesis, Universitat Politècnica de Catalunya (UPC)

    Google Scholar 

  10. Xu X (2009) Integrating advanced computer-aided design, manufacturing, and numerical control: Principles and implementations. Information Science Reference, Hershey, PA

    Book  Google Scholar 

  11. E3D-online. ToolChanger: the update you’ve all been waiting for …. https://e3d-online.com/blogs/news/toolchanger-the-update-youve-all-been-waiting-for. Accessed 10 Oct 2020

  12. Mark2. The smart way to multi-extrusion. https://magnetic-tool-changer.com/. Accessed 10 Oct 2020

  13. Mosaic. Simple, multi-material 3D printing. https://www.mosaicmfg.com/. Accessed 10 Oct 2020

  14. The original PRUSA I3 MK3S 3D printer. https://www.prusa3d.com/original-prusa-i3-mk3/. Accessed 10 Oct 2020

  15. E3D. Cyclops+. https://e3d-online.com/products/cyclops. Accessed 10 Oct 2020

  16. BotObject announces the world’s first full-color 3D printer. https://www.pcworld.com/article/2037094/botobjects-announces-the-world-s-first-full-color-3d-printer.html. Accessed 10 Oct 2020

  17. Pascale D, Simion I (2018) Multi-material 3D printer extruder concept. J Ind Des Eng Graph 13(1):25–28

    Google Scholar 

  18. Guan Y, Shen B, Zhang Y, Fu Z (2017) Design of color mixing 3D printing system based on LabVIEW. J Comput 28(6):277–287

    Google Scholar 

  19. Luis E, Pan HM, Sing SL et al (2020) 3D direct printing of silicone meniscus implant using a novel heat-cured extrusion-based printer. Polymers 12(5):1031

    Article  Google Scholar 

  20. Pusch K, Hinton TJ, Feinberg AW (2018) Large volume syringe pump extruder for desktop 3D printers. HardwareX 3:49–61

    Article  Google Scholar 

  21. Mesbahi JEL, Buj-Corral I, Mesbahi AEL (2020) Use of the QFD method to redesign a new extrusion system for a printing machine for ceramics. Int J Adv Manuf Technol 111(1–2):227–242

    Article  Google Scholar 

  22. Liu Z, Lei Q, Xing S (2019) Mechanical characteristics of wood, ceramic, metal and carbon fiber-based PLA composites fabricated by FDM. J Mater Res Technol 8:3743–3753

    Article  Google Scholar 

  23. Liu B, Wang Y, Lin Z, Zhang T (2020) Creating metal parts by fused deposition modeling and sintering. Mater Lett 263:127252

    Article  Google Scholar 

  24. Lee J, Lee H, Cheon KH et al (2019) Fabrication of poly(lactic acid)/Ti composite scaffolds with enhanced mechanical properties and biocompatibility via fused filament fabrication (FFF)–based 3D printing. Addit Manuf 30:100883

    Google Scholar 

  25. Qiu K, Zhao Z, Haghiashtiani G et al (2018) 3D printed organ models with physical properties of tissue and integrated sensors. Adv Mater Technol 3(3):1700235

    Article  Google Scholar 

  26. Estermann SJ, Pahr DH, Reisinger A (2020) Quantifying tactile properties of liver tissue, silicone elastomers, and a 3D printed polymer for manufacturing realistic organ models. J Mech Behav Biomed Mater 104:103630

    Article  Google Scholar 

  27. Wu W, Deconinck A, Lewis JA (2011) Omnidirectional printing of 3D microvascular networks. Adv Mater 23(24):H178–H183

    Article  Google Scholar 

  28. Bhattacharjee T, Zehnder SM, Rowe KG et al (2015) Writing in the granular gel medium. Sci Adv 1(8):e1500655

    Article  Google Scholar 

  29. Muth JT, Vogt DM, Truby RL et al (2014) Embedded 3D printing of strain sensors within highly stretchable elastomers. Adv Mater 26:6307–6312

    Article  Google Scholar 

  30. Liu W, Heinrich MA, Zhou Y et al (2017) Extrusion bioprinting of shear-thinning gelatin methacryloyl bioinks. Adv Healthc Mater 6(12):1601451

    Article  Google Scholar 

  31. Hinton TJ, Jallerat Q, Palchesko RN et al (2015) Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels. Sci Adv 1(9):e1500758

    Article  Google Scholar 

  32. Hinton TJ, Hudson A, Pusch K et al (2016) 3D printing PDMS elastomer in a hydrophilic support bath via freeform reversible embedding. ACS Biomater Sci Eng 2:1781–1786

    Article  Google Scholar 

  33. Zhao J, Hussain M, Wang M et al (2020) Embedded 3D printing of multi-internal surfaces of hydrogels. Addit Manuf 32:101097. https://doi.org/10.1016/j.addma.2020

    Article  Google Scholar 

  34. Tejo-Otero A, Buj-Corral I, Fenollosa-Artés F (2020) 3D printing in medicine for preoperative surgical planning: a review. Ann Biomed Eng 48:536–555

    Article  Google Scholar 

  35. Muguruza Blanco A, Krauel L, Fenollosa Artés F (2019) Development of a patients-specific 3D-printed preoperative planning and training tool, with functionalized internal surfaces, for complex oncologic cases. Rapid Prototyping J 25:363–377

    Article  Google Scholar 

  36. Krauel L, Fenollosa F, Riaza L et al (2016) Use of 3D prototypes for complex surgical oncologic cases. World J Surg 40:889–894

    Article  Google Scholar 

  37. Tejo-Otero A, Lustig-Gainza P, Fenollosa-Artés F et al (2020) 3D printed soft surgical planning prototype for a biliary tract rhabdomyosarcoma. J Mech Behav Biomed Mater 109:103844

    Article  Google Scholar 

  38. Celi S, Gasparotti E, Capellini K et al (2020) 3D printing in modern cardiology. Curr Pharm Des 26:1

    Google Scholar 

  39. Wilcox B, Mobbs RJ, Wu A-M, Phan K (2017) Systematic review of 3D printing in spinal surgery: the current state of play. J Spine Surg 3:433–443

    Article  Google Scholar 

  40. Rubio-Pérez I, Lantada AD (2020) Surgical planning of sacral nerve stimulation procedure in presence of sacral anomalies by using personalized polymeric prototypes obtained with additive manufacturing techniques. Polymers 12(3):581

    Article  Google Scholar 

  41. Wallin RF, Upman PJ (1998) A practical guide to ISO 10993-3: carcinogenity. Medical Device and Diagnostic Industry

    Google Scholar 

  42. Gu Q, Hao J, Lu YJ et al (2015) Three-dimensional bio-printing. Sci China Life Sci 58:411–419

    Article  Google Scholar 

  43. Jakab K, Norotte C, Marga F et al (2010) Tissue engineering by self-assembly and bio-printing of living cells. Biofabrication 2(2):02201

    Article  Google Scholar 

  44. Zhang L, Yang G, Johnson BN, Jia X (2019) Three-dimensional (3D) printed scaffold and material selection for bone repair. Acta Biomater 84:16–33

    Article  Google Scholar 

  45. Buj-Corral I, Bagheri A, Petit-Rojo O (2018) 3D printing of porous scaffolds with controlled porosity and pore size values. Materials 11:1532

    Article  Google Scholar 

  46. Minguella-Canela J, Calero JA, Korkusuz F et al (2020) Biological responses of ceramic bone spacers produced by green processing of additively manufactured thin meshes. Materials 13(11):2497

    Article  Google Scholar 

  47. Rubi-Sans G, Castaño O, Cano I et al (2020) Engineering cell-derived matrices: from 3D models to advanced personalized therapies. Adv Funct Mater 30(44):2000496

    Article  Google Scholar 

  48. Jakab K, Norotte C, Damon B et al (2008) Tissue engineering by self-assembly of cells printed into topologically defined structures. Tissue Eng—Part A 14:413–421

    Article  Google Scholar 

  49. Rabionet M, Guerra AJ, Puig T, Ciurana J (2018) 3D-printed tubular scaffolds for vascular tissue engineering. In: Procedia CIRP, vol 68, pp 352–357

    Google Scholar 

  50. Billiet T, Vandenhaute M, Schelfhout J et al (2012) A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering. Biomaterials 33:6020–6041

    Article  Google Scholar 

  51. Cima LG, Cima MJ (1996) Preparation of medical devices by solid free-form fabrication methods, 11. USOO5490962A

    Google Scholar 

  52. Holländer J, Genina N, Jukarainen H et al (2016) Three-dimensional printed PCL-based implantable prototypes of medical devices for controlled drug delivery. J Pharm Sci 105:2665–2676

    Article  Google Scholar 

  53. Abdollahi S, Markvicka EJ, Majidi C, Feinberg AW (2020) 3D printing silicone elastomer for patient-specific wearable pulse oximeter. Adv Healthc Mater 9(15):1901735

    Article  Google Scholar 

  54. Melgoza EL, Vallicrosa G, Serenó L et al (2014) Rapid tooling using 3D printing system for manufacturing of customized tracheal stent. Rapid Prototyping J 20:2–12

    Article  Google Scholar 

  55. Jia H, Gu SY, Chang K (2018) 3D printed self-expandable vascular stents from biodegradable shape memory polymer. Adv Polym Technol 37:3222–3228

    Article  Google Scholar 

  56. Van Doremalen N, Bushmaker T, Morris DH et al (2020) Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med 382:1564–1567

    Article  Google Scholar 

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Funding

The present chapter was co-financed by the European Union Regional Development Fund within the framework of the ERDF Operational Program of Catalonia 2014-2020, with a grant of 50% of total cost eligible, project BASE3D, grant number 001-P-001646.

Author information

Authors and Affiliations

  1. Mechanical Engineering Department, School of Engineering of Barcelona (ETSEIB), Universitat Politècnica de Catalunya (UPC), Av. Diagonal 647, 08028, Barcelona, Spain

    Irene Buj-Corral & Felip Fenollosa-Artés

  2. Centre CIM, Universitat Politècnica de Catalunya (CIM UPC), Carrer de Llorens i Artigas, 12, 08028, Barcelona, Spain

    Aitor Tejo-Otero & Felip Fenollosa-Artés

Authors
  1. Irene Buj-Corral
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  2. Aitor Tejo-Otero
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  3. Felip Fenollosa-Artés
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Corresponding author

Correspondence to Irene Buj-Corral .

Editor information

Editors and Affiliations

  1. S. V. National Institute of Technology, Surat, India

    Harshit K. Dave

  2. Department of Mechanical Engineering, Campus Santiago, University of Aveiro, Aveiro, Portugal

    J. Paulo Davim

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Buj-Corral, I., Tejo-Otero, A., Fenollosa-Artés, F. (2021). Use of FDM Technology in Healthcare Applications: Recent Advances. In: Dave, H.K., Davim, J.P. (eds) Fused Deposition Modeling Based 3D Printing. Materials Forming, Machining and Tribology. Springer, Cham. https://doi.org/10.1007/978-3-030-68024-4_15

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  • DOI: https://doi.org/10.1007/978-3-030-68024-4_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-68023-7

  • Online ISBN: 978-3-030-68024-4

  • eBook Packages: EngineeringEngineering (R0)

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