Skip to main content
SpringerLink
Log in

Chromogranin

  • Reference work entry
  • First Online:
Endocrine Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 47 Accesses

Synonyms

Granin; Secretogranin

Definition

Chromogranins are the major component of the neurosecretory granules of neuroendocrine cells, neurons, and adrenal medulla.

Features

Chromogranins are proteins belonging to the granin family, which is made of eight acid, soluble secretory proteins: Chromogranin A, Chromogranin B, Secretogranin II, Secretogranin III (1B1075), Secretogranin IV (HISL-19), Secretogranin V (7B2), Secretogranin VI (NESP55), Secretogranin VII (VGF), and Secretogranin VIII (proSAAS). Chromogranins interact with other components of the granules, such as catecholamines, serotonin, and histamine, and contribute to the formation of the neurosecretory granules, under specific conditions of low pH and high calcium levels. In addition to the role in the making of the granules, the granins are also proproteins. They contain multiple residues that are target for exogenous or endogenous tissue-specific proteolytic processing to smaller bioactive peptides, involved in different...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References and Further Reading

  • https://www.uniprot.org/uniprot/P05060. Accessed 20 Dec 2019.

    Google Scholar 

  • Lloyd, R. V. (2003). Practical markers used in the diagnosis of neuroendocrine tumors. Endocrine Pathology, 14, 293–301.

    Article  CAS  PubMed  Google Scholar 

  • Loh, Y. P., Cheng, Y., Mahata, S. K., Corti, A., & Tota, B. (2012). Chromogranin A and derived peptides in health and disease. Journal of Molecular Neuroscience, 48(2), 347–356.

    Article  CAS  PubMed  Google Scholar 

  • Taupenot, L., Harper, K. L., & O’Connor, D. T. (2003). The chromogranin–secretogranin family. New England Journal of Medicine, 348(12), 1134–1149.

    Article  CAS  PubMed  Google Scholar 

  • Troger, J., Theurl, M., Kirchmair, R., Pasqua, T., Tota, B., Angelone, T., … & Gayen, J. R. (2017). Granin-derived peptides. Progress in Neurobiology, 154, 37–61.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, ASST Sette Laghi, Varese, Italy

    Anna Maria Chiaravalli

Authors
  1. Anna Maria Chiaravalli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anna Maria Chiaravalli .

Editor information

Editors and Affiliations

  1. University of Insubria, Varese, Italy

    Stefano La Rosa

  2. Department of Medicine and Surgery, Unit of Pathology, University of Insubria, Varese, Italy

    Silvia Uccella

  3. Department of Biomedical Sciences, Humanitas University and Service of Pathology, Humanitas Research Hospital, Milan, Italy

    Silvia Uccella

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Chiaravalli, A.M. (2022). Chromogranin. In: La Rosa, S., Uccella, S. (eds) Endocrine Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-62345-6_5076

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-62345-6_5076

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-62344-9

  • Online ISBN: 978-3-030-62345-6

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation