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Sleep-Related Modulations of Heart Rate Variability, ECG, and Cardio-Respiratory Coupling

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Physics of Biological Oscillators

Part of the book series: Understanding Complex Systems ((UCS))

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Abstract

Background: Integrated physiological systems following regular rhythms are a prime example of biological oscillators. Such systems include the heart with an oscillatory activity on a time scale of 1-second and the circadian pacemaker leading to a close to 24 h sleep-wake rhythm. Other prominent physiological oscillations each characterized by specific time scales are brain waves, respiration, blood pressure and vascular activity, and sleep-stage transitions with non-REM/REM cycles. In the healthy organism, these oscillators interact with each other, and studying those interactions during physiological transitions and in patients with disorders helps to uncover and better understand the underlying mechanisms. Methods: In order to investigate the coupling of these oscillators, sleep studies with cardiorespiratory polysomnography are performed on persons with healthy sleep and with sleep disorders. Polysomnography includes the recording of the electrocardiogram (ECG), the sleep-electroencephalogram (EEG), respiration, blood pressure/pulse wave, oxygen saturation, and movement activity by means of electromyogram (EMG). The analysis is performed visually by sleep experts, and computer assisted with time domain, frequency domain, and non-linear methodologies. Results: The parameters obtained provide information on the regulation of the autonomic nervous system (ANS) during sleep. The ANS is regulated totally different during slow-wave (non-REM) and REM sleep. Beat-to-beat heart-rate variations allow us to estimate a scoring of sleep stages. To some degree it is possible to track transitions from wakefulness to sleep by solely analyzing heart-rate variations. ECG and heart rate analysis allow assessment of sleep disorders as well. Cyclical variations of heart rate combined with respiration-modulated changes in ECG morphology (amplitude of R wave and T wave) provides reliable detection of sleep-disordered breathing. Conclusions: The assessment of signals being easily accessible like ECG and heart rate can help to assess sleep, sleep stages and sleep disorders with an acceptable accuracy, even if reflecting physiological functions indirectly.

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Authors and Affiliations

  1. Interdisziplinäres Schlafmedizinisches Zentrum, Charitecentrum Für Pneumologie CC12, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany

    Thomas Penzel, Martin Glos & Ingo Fietze

  2. Saratov State University, Saratov, Russia

    Thomas Penzel

  3. Department of Physics, Bar-Ilan-University, Ramat Gan, Israel

    Yaopeng Ma & Ronny P. Bartsch

  4. Kardiovaskuläre Physik, Arbeitsgruppe Nichtlineare Dynamik, Fachbereich Physik, Humboldt-Universität Berlin, Berlin, Germany

    Jan Krämer & Niels Wessel

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  1. Thomas Penzel
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Correspondence to Thomas Penzel .

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Editors and Affiliations

  1. Department of Physics, Lancaster University, Lancaster, UK

    Aneta Stefanovska

  2. Department of Physics, Lancaster University, Lancaster, UK

    Peter V. E. McClintock

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This study was supported by the German-Israeli Foundation (GIF) Grants I-1298-415.13/2015 and I-1372-303.7/2016 and the German National Cohort study (www.nationale-kohorte.de) funded by the Federal Ministry of Education and Research (BMBF) and the Helmholtz Association. TP was partially supported by a Russian Federation Government Grant No. 075-15-2019-1885.

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Penzel, T. et al. (2021). Sleep-Related Modulations of Heart Rate Variability, ECG, and Cardio-Respiratory Coupling. In: Stefanovska, A., McClintock, P.V.E. (eds) Physics of Biological Oscillators. Understanding Complex Systems. Springer, Cham. https://doi.org/10.1007/978-3-030-59805-1_20

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