Abstract
Medicinal plants, which represent one of the greatest assets of ecosystem, have found their utilization in human life and healthcare system since early days of mankind and have still maintained their importance in modern times by virtue of maintaining their basic therapeutic curative role. Numerically constituting a large group of world flora, medicinal plants form the source for large variety of herbal drugs used for medicinal purposes. Cultivation of medicinal plants being a promising alternative to wild collection enables not only conservation of natural genetic variability and survival of critically endangered, vulnerable, endangered, endemic and rare species but also symbolizes a potent economy branch for pharmaceutical industry as source of their quality raw material. Medicinal plants owe their curative value to naturally occurring biologically active ingredients in them, i.e. the primary and secondary metabolites which obtained either in pure or combined form with other molecules form a pivotal source of drug lead compounds. Growth and development of medicinal plants and medicinally active chemical metabolites found in them are influenced by the abiotic factors and biotic factors. The resurgence in recognizing medicinal plants as a source of drugs and other products is mainly due to their effectiveness, with no to little side effects associated with their application and as an alternate to high-cost synthetic drugs. Though herbal medicine has become more mainstream world over during the last few decades, their safety, quality and effectiveness still remain a key issue. The renewed interest in medicinal plants expanded their market demand which however coupled with their already rather limited availability and potential overharvesting have brought about alarming biodiversity problems sounding the need to evaluate and conserve our old prized natural germplasm.
This chapter deals with stocking of knowledge regarding use of medicinal plants, their correct identification, their chemical constitution, factors involved in their quality production and also that of naturally occurring bioactive principles, as well concerns with regard to their quality and control parameters thereof. The chapter also gives insight into their conservation aspect especially from the viewpoint of sustainability as they represent the substantial proportion of the global drug market.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Adekunle AS, Adekunle OC (2009) Preliminary assessment of antimicrobial properties of aqueous extract of plants against infectious diseases. Biol Med 1:20–24
Aniszewski T (2007) Alkaloids-secrets of life alkaloid chemistry, biological significance, applications and ecological role. Elsevier, Amsterdam, pp 1–316
Balandrin MF, Kinghorn AD and Farnsworth NR (1993) Plant-derived natural products in drug discovery and development: an overview human medicinal agents from plants. In: Kinghorn AD, Balandrin MF (eds) American chemical society symposium. Washington, DC, 534:2–12
Baricevic D, Ratajc P, Zupan M, Turk B, Vres B, Seliskar A, Seliskar T (2012) Conservation and evaluation of genetic resources of medicinal plants. Acta Agric Slov 99:363–371
Bennett BC, Balick MJ (2008) Phytomedicine 101: plant taxonomy for preclinical and clinical medicinal plant researchers. J Soc Integr Oncol 6:150–160
Bruneton J (1999) Pharmacognosy phytochemistry medicinal plants, 2nd edn. Lavoisier, Paris
Canter PH, Thomas H, Ernst E (2005) Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology. Trends Biotechnol 23:180–185
Chan K (2002) Understanding the toxicity of Chinese Herbal Medicinal products. In: Chan K, Lee H (eds) The way forward for Chinese medicines. Taylor & Francis, London
Chatterjee SK (1996) Cultivation of phytochemical plants for use in phytochemicalIndustries In: Pakrashi SC, Mukherjee RN, Mukhopodhaya S, Bhavan MM (eds) Medicinal Plants, Herbal Drugs and Rural Health. Calcutta, India 112–127
Chen JJ, Fang HY, Duh CY, Chen IS (2005) New indolopyridoquinazoline, benzophenanthridines and cytotoxic constituents from Zanthoxylum integrifolium. Planta Med 71:470–475
Cook NS, Samman S (1996) Flavonoids – chemistry, metabolism, cardioprotective effect and dietary sources. J Nutr Biochem 7:66–76
Daniel M (2006) Medicinal plants: chemistry and properties. IBH Publishing, Oxford
Dewick PM (2002) Medicinal natural products. Wiley, West Sussex
Dixon R, Ferreira D (2002) Molecules of interest: genistein. Phytochemistry 60:205–211
Dixon RA, Sumner LW (2003) Legume natural products: understanding and manipulating complex pathways for human and animal health. Plant Physiol 131:878
Doughari JH, Human IS, Bennade S, Ndakidemi PA (2009) Phytochemicals as chemotherapeutic agents and antioxidants: possible solution to the control of antibiotic resistant verocytotoxin producing bacteria. J Med Plant Res 3:839–848
Edeoga HO, Okwu DE, Mbaebie BO (2005) Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol 4:685–688
Edeoga HO, Omosun G, Uche LC (2006) Chemical composition of Hyptis suaveolens and Ocimum gratissimum hybrids from Nigeria. Afr J Biotechnol 5:892–895
Erdemgil FZ, Telezhenetskaya MV, Baser KHC, Kirimer N (2000) Alkaloids of Thalictrum orientale growing in Turkey. Chem Nat Compd 36:223–224
Farnsworth NR, Soejarto DD (1997) Global importance of medicinal plants. Cambridge University Press, Cambridge UK
Fennell CW, Lindsey KL, McGaw LJ, Sparg SG, Stafford GI, Elgorashi EE, Grace OM, Van Staden JJ (2004) Assessing African medicinal plants for efficacy and safety: pharmacological screening and toxicology. Ethnopharmacology 94:205–217
Firn R (2010) Nature’s chemicals. Oxford University Press, Oxford, pp 74–75
Forgo P, Hohmann J (2005) Leucoverine and acetyllycovernine, alkaloids from Leucojum vernum. J Nat Prod 68:1588–1591
Frederich M, Tits M, Golffin E, Philippe G, Grellier P, Mol PD, Hayette MP, Angenot L (2004) In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis. Planta Med 70:520–525
Gepts P (2006) Plant genetic resources conservation and utilization: the accomplishments and future of a societal insurance policy. Crop Sci 46:2278–2292
Goldman P (2001) Herbal medicines today and the roots of modern pharmacology. Ann Intern Med 135:594–600
Graham LE, Graham JM, Wilcox LW (2006) Plant biology. Pearson/Prentice Hall, Upper Saddle River, p 670
Haberer W, Witte L, Hartman T, Dobler S (2002) Pyrrolizidine alkaloids in Pulmonaria obscura. Planta Med 68:480–482
Hachfeld B, Schippmann U (2000) Conservation data sheet 2: exploitation, trade and population status of Harpagophytum procumbens in Southern Africa. Med Plant Conserv 6:4–9
Hegenauer R (1986) Phytochemistry and plant taxonomy, an essay on the chemotaxonomy of higher plants. Phytochemistry 25:1519–1535
Hegnauer R (1963) The taxonomic significance of alkaloids. In: Swain T (ed) Chemical plant taxonomy. Academic Press, London/New York, pp 389–427
Herrera MR, Machocho AK, Brun R, Viladomat F, Codina C, Bastida J (2001) Crinane and lycorane type alkaloids from Zephyranthes citrina. Planta Med 67:191–193
Innerhofer S, Bernhardt KG (2011) Ethnobotanic garden design in the Ecuadorian Amazon. Biodivers Conserv 20:429–439
Jacobson JM, Feinman L, Liebes L, Ostrow N, Koslowski V (2001) Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John’s Wort plant, in patients with chronic hepatitis C virus infection. Antimicrob Agents Chemother 45:517–524
Janses BJM, de Groot A (2004) Occurrence, biological activity and synthesis of Drimane Sesquiterpenoids. Nat Prod Rep 21:449–477
Jiang Y, Li H, Cai P, Ye W (2005) Steroidal alkaloids from the bulbs of Fritollaria puqiensis. J Nat Prod 68:264–267
Johns T, Eyzaguirre PB (2000) Nutrition for sustainable environments. SCN News 21:24–29
Kasper S (2001) Hypericum perforatum - a review of clinical studies. Pharmacopsychiatry 34:51–55
Khamidov II, Aripova SF, Karimov AK (2003) Berberis alkaloids. XLI. Alkaloids from leaves ofcultivated Berberis oblonga. Chem Nat Compd 39:407
Lamartinier CA (2000) Protection against breast cancer with genistein: a component of soy. Am J Clin Nutr 71:1705S–1707S
Lange D (1998) Europe’s medicinal and aromatic plants: their use, trade and conservation’. TRAFFIC Europe International, Cambridge, UK
Lansiaux A, Bailly C, Houssier C, Colson P, de Pauw-Gillet M-C, Frederich M, Tits M, Angenot L (2002) Apoptosis of H-60 leukemia cells induced by the bisindole alkaloids sungucine and isosungucine from Strychos icaja. Planta Med 68:591–595
Liu RH (2004) Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 134:3479S–3485S
Long CL, Li H, Ouyang ZQ, Yang XY, Li Q, Trangmar B (2003) Strategies for agrobiodiversity conservation and promotion: a case from Yunnan, China. Biodivers Conserv 12:1145–1156
Macabeo AP, Krohn K, Gehle D, Read RW, Brophy JJ, Cordell GA, Franzblau SG, Aguinaldo AM (2005) Indole alkaloids from the leaves of Philippine Alstonia scholaris. Phytochemistry 66:1158–1162
Maurya R, Singh G, Yadav PP (2008) Antiosteoporotic agents from natural sources. In: Atta-ur-Rahman (ed) Studies in natural products chemistry, vol 35. Elsevier, Burlington, pp 517–545
McKenzie M, Kirakosyan A, Kaufman PB (2009) Risks associated with overcollection of medicinal plants in natural habitats. In: Kirakosyan A, Kaufman PB (eds) Recent advances in plant biotechnology. Springer, New York, pp 363–387
Minelli A (1993) Biological systematics: the state of the art. Chapman & Hall, New York
Miththapala S (2006) Conserving medicinal species: securing a healthy future. IUCN, Ecosystems and Livelihoods Group, Colombo
Mothes K, Schutte HR, Luckner M (1985) Biochemistry of alkaloids, vol 18. VEB Berlin, p 107
Mulliken TA (2000) Implementing CITES for Himalayan medicinal plants Nardostachys grandiflora and Picrorhiza kurrooa. Traffic Bull 18:63–72
Mustafa NR, Verpoorte R (2005) Chorismate derived C6C1 compounds in plants. Planta 222:1–5
Naikoo MI, Dar MI, Raghib F, Jaleel H, Ahmad B, Raina A, Khan FA, Naushin F (2019) Role and regulation of plants phenolics in abiotic stress tolerance: an overview. In: Khan MIR, Reddy PS, Ferrante A, Khan NA (eds) Plant signaling molecules. Woodhead Publishing, Cambridge pp 157–168
Nazrullaev SS, Bessonova IA, Akhmedkhodzhaeva KS (2001) Estrogenic activity as a function of chemical structure in Haplophyllum quinoline alkaloids. Chem Nat Compd 37:551–555
Oksman-Caldentey KM (2007) Tropane and nicotine alkaloid biosynthesis-novel approaches towards biotechnological production of plant-derived pharmaceuticals. Curr Pharm Biotechnol 8:203–210
Okwu DE (2004) Phytochemicals and vitamin content of indigenous spices of South Eastern Nigeria. J Sustain Agric Environ 6:30–34
Okwu DE, Ekeke O (2003) Phytochemical screening and mineral composition of chewing sticks in south eastern Nigeria. Global J Pure Appl Sci 9(2):235–238
Okwu DE, Okwu ME (2004) Chemical composition of Spondias mombin Linn plant parts. J Sustain Agric Environ 6:140–147
Okwu DE, Omodamiro OD (2005) Effects of hexane extract and phytochemical content of Xylopia acthiopica and Ocimum gratissimum on the uterus of Guinea pig. Bio-Research 3:40–44
Oudin A, Courtois M, Rideau M, Clastre M (2007) The iridoid pathway in Catharanthus roseus alkaloid biosynthesis. Phytochem Rev 6:259–276
Pelser PB, de Vos H, Theuring C, Beuerle T, Vrieling K, Hartmann T (2005) Frequent gain and loss of pyrrolizidine alkaloids in the evolution of Senecio section Jacobaea (Asteraceae). Phytochemistry 66:1285–1295
Przybylak JK, Ciesiolka D, Wysocka W, Garcia-Lopez PM, Ruiz-Lopez MA, Wysocki W, Gulewicz K (2005) Alkaloid profiles of Mexican wild lupin and an effect of alkaloid preparation from Lupinus exaltatus seeds on growth and yield of paprika (Capsicum annuum L.). Ind Crop Prod 21:1–7
Pulliam HR (2003) On the relationship between niche and distribution. Ecol Lett 3:349–361
Puupponen-Pimia R, Nohynek L, Alakomi H, Oksman-Caldentey K (2008) The action of berry phenolics against human intestinal pathogens. Biofactors 23:243–251
Ramawat KG (2007) Secondary metabolites in nature. In: Ramawat KG, Merillon JM (eds) Biotechnology: secondary metabolites. Science Publishers, Enfield, p 21
Ramawat KG, Sonie KC, Sharma MC (2004) Therapeutic potential of medicinal plants: an introduction. In: Ramawat KG (ed) Biotechnology of medicinal plants: Vitalizer and therapeutic. Science Publishers, Enfield, p 1
Rates SMK (2001) Plants as source of drugs. Toxicon 39:603–613
Rizvi SA, Neidt EM, Cui J, Feiger Z, Skau CT, Gardel ML, Kozmin SA, Kovar DR (2009) Identification and characterization of a small molecule inhibitor of form in mediated actin assembly. Chem Biol 16(11):1158–1168
Robbins WW, Weier TE, Stocking CR (1957) Botany: an introduction to plant science, 2nd edn. Wiley, New York, p 578
Saganuwan A (2010) Some medicinal plants of Arabian peninsula. J Med Plant Res 4:767–789
Salako VK, Fandohan B, Kassa B, Assogbadjo AE, Idohou AFR, Gbedomon RC, Chakeredza S, Dulloo ME, Kakaı RG (2014) Home gardens: an assessment of their biodiversity and potential contribution to conservation of threatened species and crop wild relatives in Benin. Genet Resour Crop Evol 61:313–330
Salimov BT (2001) Delcorinine, a new alkaloid from Delphinium corymbosum. Chem Nat Compd 37:272–273
Sarker SD, Nahar L (2007) Chemistry for pharmacy students general, organic and natural product chemist. Wiley Chichester, UK, pp 283–359
Schwarz A, Felippe EC, Bernardi MM, Spinosa HS (2005) Impaired female sexual behavior of rat offspring exposed to Solanum lycocarpum unripe fruits during gestation and lactation: lack of hormonal and fertility alterations. Pharmacol Biochem Behav 81:928–934
Shengji P (2001) Ethnobotanical approaches of traditional medicine studies: some experiences from Asia. Pharm Boil 39:74–79
Shimmer O, Haefele F, Kruger A (1998) High resolution transmission electron microscopy studies of metal/ceramics interfaces. Mutat Res 206:201–208
Siciliano T, De Leo M, Bader A, De Tommasi N, Vrieling K, Braca A, Morelli I (2005) Pyrrolizidine alkaloids from Anchusa strigosa and their antifeedant activity. Phytochemistry 66:1593–1600
Simon JE (1999) Domestication and production considerations in quality control of Botanicals. In: Eskinazi D, Blumenthal M, Farnsworth N, Riggins CW (eds) Botanical Medicine. Efficacy, Quality Assurance, and Regulation. Mary Ann Liebert, Inc. Larchmont, NY, pp 133–137
Singh G (2004) Plant systematics. An integrated approach. Science Publishers, Enfield-Plymouth
Smolinski MS, Hamburg MA, Lederberg J (eds) (2003) Microbial threats to health: emergence, detection, and response. National Academies Press, Washington, DC, pp 203–210
Sofowara A (1993) Medicinal plants and traditional medicine in Africa. Spectrum Books Ltd., Ibadan, p 289
Srivastava S, Singh MM, Kulshreshtha DK (2001) A new alkaloid and other anti-implantation principles from Tabernaemontana heyneana. Planta Med 67:577–557
Sultankhodzaev MN, Tashkhodzhaev B, Averkiev BB, Antipin MY (2002) Secokaraconitine, a new diterpenoid alkaloid from Aconitum karacolicum. Chem Nat Compd 38:78–82
Swarts ND, Dixon KW (2009) Terrestrial orchid conservation in the age of extinction. Ann Bot 104:543–556
Switzer H, Karki M, Vedavathy B (2003) Commercialization of natural resources for sustainable livelihoods: the case of forest products. In: ICIMOD (ed) Growth, poverty alleviation and sustainable management in the Mountain Areas of South Asia. ICIMOD, Kathmandu, pp 293–320
Terpo A (1992) Taxonomy of medicinal plants. In: Hornok L (ed) Cultivation and processing of medicinal plants. Akademiai Kiado, Budapest, pp 42–55
Uesugi T, Toda T, Tsuji K, Ishida H (2001) Comparative study on reduction of bone loss and lipid metabolism abnormality in ovariectomized rats by soy isoflavones, daidzin, genistin, and glycitin. Biol Pharm Bull 24:368–372
Uruquiaga I, Leighton F (2000) Plant polyphenol antioxidants and oxidative stress. Biol Res 33:159–165
Vagujfalvi D (1992) Active substances in medicinal plants. In: Hornok L (ed) Cultivation and processing of medicinal plants. Akademiai Kiado, Budapest, pp 19–41
Venugopala KN, Rashmi V, Odhav B (2013) Review on natural coumarin lead compounds for their pharmacological activity. Biomed Res Int 2013:1–14
WHO (1999) WHO monographs on selected medicinal plants, Vol I–IV, Geneva
WHO (2013) The WHO Traditional Medicine Strategy 2014–2023. WHO, Geneva
Wink M (2000) Biochemistry of plant secondary metabolism: annual plant review, vol 2. Academic, Sheffield, p 151
WWF & IUCN (1997) Centers of plant diversity: a guide and strategy for their conservation. IUCN Publications Unit, Cambridge, UK
Yadav NP, Dixit VK (2008) Recent approaches in herbal drug standardization. Int J Integr Biol 2:195–203
Zlobin YA (2012) Rare plant species: floristic, phytocenotic and population approaches. Biol Bull Rev 2:226–237
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Ahad, B., Shahri, W., Rasool, H., Reshi, Z.A., Rasool, S., Hussain, T. (2021). Medicinal Plants and Herbal Drugs: An Overview. In: Aftab, T., Hakeem, K.R. (eds) Medicinal and Aromatic Plants. Springer, Cham. https://doi.org/10.1007/978-3-030-58975-2_1
Download citation
DOI: https://doi.org/10.1007/978-3-030-58975-2_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-58974-5
Online ISBN: 978-3-030-58975-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)