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Apoptosis and Neurocognitive Effects of Intravenous Anesthetics

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Pediatric Sedation Outside of the Operating Room

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Abstract

Drugs used for sedation have been unequivocally linked to abnormal development of the central nervous system in laboratory models. The notion of sedative-induced neurocognitive deficits in children has led to concerns about the safety of these drugs. Published clinical studies are retrospective and lack specifics about medications, monitoring and coexisting medical conditions. These retrospective studies have not definitively shown an association between sedatives and adverse neurocognitive sequelae. Practitioners and families should be reassured that although sedative have the potential to induce neurotoxicity, very little clinical evidence exists to support this concern.

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  1. Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Boston, MA, USA

    Sulpicio G. Soriano

  2. Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, Geneva, Switzerland

    Laszlo Vutskits

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  1. Sulpicio G. Soriano
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  2. Laszlo Vutskits
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Correspondence to Sulpicio G. Soriano .

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  1. Department of Anesthesiology, Harvard Medical School, Boston, MA, USA

    Keira P. Mason, MD

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Soriano, S.G., Vutskits, L. (2021). Apoptosis and Neurocognitive Effects of Intravenous Anesthetics. In: Mason, MD, K.P. (eds) Pediatric Sedation Outside of the Operating Room. Springer, Cham. https://doi.org/10.1007/978-3-030-58406-1_33

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  • DOI: https://doi.org/10.1007/978-3-030-58406-1_33

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-58405-4

  • Online ISBN: 978-3-030-58406-1

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