Abstract
Cardiovascular parameters like blood pressure, heart rate, heart rhythm, and heart rate variability are highly useful in assessing patient health, disease risk, and response to treatment. However, technological limitations curtail their measurement in many cases. The recent development of transdermal optical imaging (TOI) technology has made it possible to extract high-quality blood flow information from conventional video of a patient’s face and then use it to accurately estimate these cardiovascular parameters. TOI technology could thus be implemented on any device capable of capturing and processing video (e.g., any modern smartphone) and thus constitute a comfortable, convenient, and ubiquitous tool for measuring cardiovascular parameters.
TOI builds upon remote photoplethysmography in part by using machine learning to extract robust blood flow information from video of the face. This signal can be used directly to compute heart rate, heart rhythm, and heart rate variability. Information from signal features containing blood pressure information has been combined with the help of machine learning to accurately estimate systolic and diastolic pressures. Further development of this technology is likely to enable the assessment of additional physiological parameters (e.g., respiration rate, SpO2), disease risks (e.g., hypertension, diabetes), blood biomarker concentrations (e.g., cholesterol, HbA1c), and even mental health conditions (e.g., depression, anxiety).
With the necessary regulatory approvals and clinical trials, TOI-based tools would enable accurate, convenient, and contactless screening, diagnosis, and monitoring of patient health. They would revolutionize healthcare delivery through better access and efficiency and thus not only reduce costs but also improve health worldwide.
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References
Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global disparities of hypertension prevalence and control. Circulation. 2016;134(6):441–50.
Barszczyk A, Yang D, Wei J, Huang W, Feng Z-P, Lee K, et al. Potential impact of the 2017 high blood pressure guideline beyond the United States: a case study of the People’s Republic of China. Am J Hypertens. 2020;33(9):846–51.
Oparil S. Global blood pressure screening: a wakeup call. Hypertension. Lippincott Williams and Wilkins. 2020;76:318–20.
Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Pr. J Am Coll Cardiol. 2018;71(19):e127–248.
Mahdi A, Watkinson P, McManus RJ, Tarassenko L. Circadian blood pressure variations computed from 1.7 million measurements in an acute hospital setting. Am J Hypertens. 2019;32(12):1154–61.
Bartels K, Esper SA, Thiele RH. Blood pressure monitoring for the anesthesiologist. Anesth Analg. 2016;122(6):1866–79.
Ponikowski P, Spoletini I, Coats AJ, Piepoli MF, Rosano GM. Heart rate and blood pressure monitoring in heart failure. European Heart Journal Supplements. 2019;21(Supplement_M):M13–16.
Stauss HM. Heart rate variability. Am J Physiol – Regul Integr Comp Physiol. 2003;285(5):R927–R931.
Ahmad S, Tejuja A, Newman KD, Zarychanski R, Seely AJE. Clinical review: a review and analysis of heart rate variability and the diagnosis and prognosis of infection. Crit Care. 2009;13(6):1–7.
Kleiger RE, Thomas Bigger J, Bosner MS, Chung MK, Cook JR, Rolnitzky LM, et al. Stability over time of variables measuring heart rate variability in normal subjects. Am J Cardiol. 1991;68:626.
Kim HG, Cheon EJ, Bai DS, Lee YH, Koo BH. Stress and heart rate variability: a meta-analysis and review of the literature. Psychiatry Investig. Korean Neuropsychiatric Association. 2018;15:235–45.
Liu J, Luo H, Zheng PP, Wu SJ, Lee K. Transdermal optical imaging revealed different spatiotemporal patterns of facial cardiovascular activities. Sci Rep. 2018;8(1):10588.
Wei J, Luo H, Wu SJ, Zheng PP, Fu G, Lee K. Transdermal optical imaging reveal basal stress via heart rate variability analysis: a novel methodology comparable to electrocardiography. Front Psychol. 2018;9:98.
Luo H, Yang D, Barszczyk A, Vempala N, Wei J, Wu SJ, et al. Smartphone-based blood pressure measurement using transdermal optical imaging technology. Circ Cardiovasc Imaging. 2019;12(8):e008857.
Barszczyk A, Lee K. Measuring blood pressure: from cuff to smartphone. Curr Hypertens Rep. 2019;21(11):1–4.
Mukkamala R. Blood pressure with a click of a camera? Circulation: Cardiovasc Imaging. 2019;12(8):e009531–e009531.
Yang D, Xiao G, Wei J, Luo H. Preliminary assessment of video-based blood pressure measurement according to ANSI/AAMI/ISO81060-2:2013 guideline accuracy criteria: Anura smartphone app with transdermal optimal imaging technology. Blood Press Monit. 2020;25(5):295–298.
Gallagher D, Adji A, O’Rourke MF. Validation of the transfer function technique for generating central from peripheral upper limb pressure waveform. Am J Hypertens. 2004;17(11):1059–1067.
Verkruysse W, Svaasand LO, Nelson JS. Remote plethysmographic imaging using ambient light. Opt Express. 2008;16(26):21434–21445.
Kamshilin AA, Margaryants NB. Origin of photoplethysmographic waveform at green light. Phys Procedia. 2017;86:72–80.
Takano C, Ohta Y. Heart rate measurement based on a time-lapse image. Med Eng Phys. 2007;29(8):853–857.
Lewandowska M, Rumiński J, Kocejko T, Nowak J. Measuring pulse rate with a webcam – a non-contact method for evaluating cardiac activity. In: 2011 Federated conference on computer science and information systems, FedCSIS 2011. 2011.
Jain M, Deb S, Subramanyam AV. Face video based touchless blood pressure and heart rate estimation. In: 2016 IEEE 18th international workshop on multimedia signal processing, MMSP 2016. 2017.
De Haan G, Jeanne V. Robust pulse rate from chrominance-based rPPG. IEEE Trans Biomed Eng. 2013;60(10):2878–2886.
Moço A V., Stuijk S, de Haan G. Motion robust PPG-imaging through color channel mapping. Biomed Opt Express. 2016;7(5):1737–1754.
Adachi Y, Edo Y, Ogawa R, Tomizawa R, Iwai Y, Okumura T. Noncontact blood pressure monitoring technology using facial photoplethysmograms. In: Proceedings of the annual international conference of the IEEE engineering in medicine and biology society, EMBS. 2019.
Drummond PD. Psychophysiology of the blush. In: The psychological significance of the blush. Cambridge University Press; 2009.
Elgendi M. On the analysis of fingertip photoplethysmogram signals. Curr Cardiol Rev. 2012;8(1):14–25.
Fisher JP, Paton JFR. The sympathetic nervous system and blood pressure in humans: implications for hypertension. J Hum Hypertens. Nature Publishing Group. 2012;26:463–75.
Association for the Advancement of Medical Instrumentation. ANSI/AAMI/ISO 81060-1:2007/(R)2013 Non-invasive sphygmomanometers – Part2: Clinical investigation of automated measurement type. 2013.
Roy B, Ghatak S. Nonlinear methods to assess changes in heart rate variability in Type 2 diabetic patients. Arq Bras Cardiol. 2013;101:317–327.
Melillo P, Bracale M, Pecchia L. Nonlinear heart rate variability features for real-life stress detection. Case study: students under stress due to university examination. Biomed Eng Online. 2011;10:96.
GSMA MC. mHealth: a new vision for healthcare [Internet]. 2012. https://www.gsma.com/iot/wp-content/uploads/2012/03/gsmamckinseymhealthreport.pdf
Tarride J-E, Lim M, DesMeules M, Luo W, Burke N, O’Reilly D, et al. A review of the cost of cardiovascular disease. Can J Cardiol. 2009;25(6):e195–202.
Ottawa Heart Institute: Telehome Monitoring [Internet]. https://www.ottawaheart.ca/healthcare-professionals/regional-national-programs/telehome-monitoring
Broderick A, Lindeman D. Scaling telehealth programs: lessons from early adopters. The Commonwealth Fund. 2013;1654(1):1–10.
Lakhdar K, Black G. Blurring the lines: convergence in Canadian Health & Life Sciences [Internet]. KPMG. https://assets.kpmg/content/dam/kpmg/pdf/2016/05/Blurringthelines-Convergence-in-Canadian-HLS.pdf
Kayyali B, Kimmel Z, van Kuiken S. Spurring the market for high-tech home health care. McKinsey & Company [Internet]. http://www.mckinsey.com/industries/healthcare-systems-and-services/our-insights/spurring-the-market-for-high-tech-home-health-care
Lyons TJ, Basu A. Biomarkers in diabetes: hemoglobin A1c, vascular and tissue markers. Transl Res. 2012;159(4):303–312.
Association for the Advancement of Medical Instrumentation. ANSI/AAMI/EC13:2002 Cardiac monitors, heart rate meters, and alarms. 2002.
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Barszczyk, A., Zhou, W., Lee, K. (2021). AIM and Transdermal Optical Imaging. In: Lidströmer, N., Ashrafian, H. (eds) Artificial Intelligence in Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-58080-3_250-1
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DOI: https://doi.org/10.1007/978-3-030-58080-3_250-1
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