Synonyms
Cardiac steroids; Cardiotonic steroids; Digitalis
Cardiac glycosides are pharmacologically active compounds derived from different plants and the toad venom. Furthermore, these endogenous compounds evidently control blood pressure, and disturbances in their physiological levels have been observed in several diseases, including myocardial ischemia and infarction, diabetes, and cancer. Cardiac glycosides act on the membrane-bound sodium-potassium-adenosine triphosphatase (Na+/K+-ATPase) pump. The most important cardiac glycosides are digoxin, digitoxin, and ouabain (Fig. 1).
Cardiac glycosides – molecular structure of digoxin, digitoxin, and ouabain
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Soto-Blanco, B. (2021). Cardiac Glycosides. In: Offermanns, S., Rosenthal, W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-57401-7_36
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