Synonyms
Definition
Cancer immunotherapy identifies a type of cancer treatment that acts by exploiting the immune system. The term cancer immunotherapy can identify whether a treatment capable of activating the host immune system or be used to describe components of the immune system (synthetic, autologous, or allogeneic) that are administered to the host. Immunotherapy can be distinguished as follows: (1) active, i.e., exerts its effect only by engaging with the host immune system, or (2) passive, i.e., is designed to have a direct antineoplastic activity (Galluzzi et al. 2014).
Examples of active immunotherapy are monoclonal antibodies (MoAb) that can modulate immune effector cells activation or vaccines. Passive immunotherapy includes MoAb directed against protein expressed on the surface of cancer cells or the infusion of genetically modified immune cells (mainly T cells).
Basic Mechanism
Monoclonal Antibodies
Monoclonal antibodies...
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References
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Brioli, A., Hochhaus, A. (2021). Cancer Immunotherapy. In: Offermanns, S., Rosenthal, W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-57401-7_10052
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DOI: https://doi.org/10.1007/978-3-030-57401-7_10052
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