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Timing of Birth in Uncomplicated Twin Pregnancy

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Twin and Higher-order Pregnancies
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Abstract

Twin pregnancies are at higher risk of perinatal morbidity and mortality. Research has shown that the risk of stillbirth significantly increases before 40 weeks in twins, with a degree of variation between different chorionicity and amnionicity. Antenatal complications that are specific or more prevalent in twin pregnancies can occur, contributing to their increased rates of perinatal loss. National recommendations are now in place based on expert opinions and available evidence, in order to mitigate these risks.

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References

  1. Sairam S, Costeloe K, Thilaganathan B. Prospective risk of stillbirth in multiple-gestation pregnancies: a population-based analysis. Obstet Gynecol. 2002;100:638–41.

    PubMed  Google Scholar 

  2. Ehsanipoor RM, Haydon ML, Lyons Gaffaney C, et al. Gestational age at cervical length measurement and preterm birth in twins. Ultrasound Obstet Gynecol. 2012;40:81–6.

    Article  CAS  Google Scholar 

  3. Elliott JP, Istwan NB, Collins A, et al. Indicated and nonindicated preterm delivery in twin gestations: impact on neonatal outcome and cost. J Perinatol. 2005;25:4–7.

    Article  Google Scholar 

  4. Townsend R, Khalil A. Fetal growth restriction in twins. Best Pract Res Clin Obstet Gynaecol. 2018;49:79–88.

    Article  CAS  Google Scholar 

  5. Dias T, Akolekar R. Timing of birth in multiple pregnancy. Best Pract Res Clin Obstet Gynaecol. 2014;28(2):319–26.

    Article  Google Scholar 

  6. D’Antonio F, Odibo AO, Prefumo F, Khalil A, Buca D, Flacco ME, Liberati M, Manzoli L, Acharya G. Weight discordance and perinatal mortality in twin pregnancy: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018;52(1):11–23.

    Article  Google Scholar 

  7. Townsend R, Khalil A. Twin pregnancy complicated by selective growth restriction. Curr Opin Obstet Gynecol. 2016;28(6):485–91.

    Article  Google Scholar 

  8. Valsky DV, Eixarch E, Martinez JM, Crispi F, Gratacós E. Selective intrauterine growth restriction in monochorionic twins: pathophysiology, diagnostic approach and management dilemmas. Semin Fetal Neonatal Med. 2010;15:342–8.

    Article  Google Scholar 

  9. Stirrup OT, Khalil A, D’Antonio F, Thilaganathan B. Fetal growth reference ranges in twin pregnancy: analysis of the Southwest Thames Obstetric Research Collaborative (STORK) multiple pregnancy cohort. Ultrasound Obstet Gynecol. 2015;45(3):301–7.

    Article  CAS  Google Scholar 

  10. D’Antonio F, Khalil A, Dias T, Southwest Thames Obstetric Research Collaborative (STORK), et al. Early fetal loss in monochorionic and dichorionic twin pregnancies: analysis of the Southwest Thames Obstetric Research Collaborative (STORK) multiple pregnancy cohort. Ultrasound Obstet Gynecol. 2013;41:432–6.

    Google Scholar 

  11. Wu D, Huang L, He Z, et al. Pre-eclampsia in twin pregnancies: association with selective intrauterine growth restriction. J Matern Fetal Neonatal Med. 2016;29:1967–71.

    Article  CAS  Google Scholar 

  12. National Institute for Health and Clinical Excellence. Twin and triplet pregnancy. NICE clinical guideline 137. London: National Institute for Health and Clinical Excellence; 2019.

    Google Scholar 

  13. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Munson ML. Births: final data for 2002. National vital statistics reports, vol. 52, no. 10. Hyattsville: National Center for Health Statistics; 2003.

    Google Scholar 

  14. Roberts WE, Morrison JC. Has the use of home monitors, fetal fibronectin, and measurement of cervical length helped predict labor and/or prevent preterm delivery in twins? Clin Obstet Gynecol. 1998;41:95–102.

    Article  Google Scholar 

  15. Conde-Agudelo A, Romero R. Prediction of preterm birth in twin gestations using biophysical and biochemical tests. Am J Obstet Gynecol. 2014;211:583–95.

    Article  Google Scholar 

  16. Conde-Agudelo A, Romero R, Hassan SS, Yeo L. Transvaginal sonographic cervical length for the prediction of spontaneous preterm birth in twin pregnancies: a systematic review and meta-analysis. Am J Obstet Gynecol. 2010;203:128.e1–12.

    Article  Google Scholar 

  17. Romero R, Conde Agudelo A, El-Refaie W, Rode L, Brizot ML, Cetingoz E, Serra V, Da Fonseca E, Abdelhafez MS, Tabor A, Perales A, Hassan SS, Nicolaides KH. Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: an updated meta-analysis of individual patient data. Ultrasound Obstet Gynecol. 2017;49(3):303–14.

    Article  CAS  Google Scholar 

  18. Hall JG. Twinning. Lancet. 2003;362:735–43.

    Article  Google Scholar 

  19. Lewi L, Jani J, Blickstein I, Huber A, Gucciardo L, Van Mieghem T, Done E, Boes AS, Hecher K, Gratacos E, Lewi P, Deprest J. The outcome of monochorionic diamniotic twin gestations in the era of invasive fetal therapy: a prospective cohort study. Am J Obstet Gynecol. 2008;199:514.e1–8.

    Article  Google Scholar 

  20. Baxi LV, Walsh CA. Monoamniotic twins in contemporary practice: a single-center study of perinatal outcomes. J Matern Fetal Neonatal Med. 2010;23:506–10.

    Article  Google Scholar 

  21. Pasquini L, Wimalasundera RC, Fisk NM. Management of other complications specific to monochorionic twin pregnancies. Best Pract Res Clin Obstet Gynaecol. 2004;18:577–99.

    Article  CAS  Google Scholar 

  22. Sebire NJ, Snijders RJ, Hughes K, et al. The hidden mortality of monochorionic twin pregnancies. Br J Obstet Gynaecol. 1997;104:1203–7.

    Article  CAS  Google Scholar 

  23. Kalyoncu O, Aygun C, Cetinoglu E, et al. Neonatal morbidity and mortality of late-preterm babies. J Matern Fetal Neonatal Med. 2010;23:607–12.

    Article  Google Scholar 

  24. Kahn B, Lumey LH, Zybert PA, et al. Prospective risk of fetal death in singleton, twin, and triplet gestations: implications for practice. Obstet Gynecol. 2003;102:685–92.

    PubMed  Google Scholar 

  25. Hack KEA, Derks JB, Elias SG, et al. Increased perinatal mortality and morbidity in monochorionic versus dichorionic twin pregnancies: clinical implications of a large Dutch cohort study. BJOG. 2008;115:58–67.

    Article  CAS  Google Scholar 

  26. Cheong-See F, Schuit E, Arroyo-Manzano D, Khalil A, Barrett J, Joseph KS, et al. Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis. BMJ. 2016;354:i4353. https://doi.org/10.1136/bmj.i4353.

    Article  PubMed  PubMed Central  Google Scholar 

  27. D’Antonio F, Khalil A, Dias T, Thilaganathan B, Southwest Thames Obstetric Research Collaborative (STORK). Early fetal loss in monochorionic and dichorionic twin pregnancies: analysis of the Southwest Thames Obstetric Research Collaborative (STORK) multiple pregnancy cohort. Ultrasound Obstet Gynecol. 2014;41(6):632–6.

    Article  Google Scholar 

  28. Southwest Thames Obstetric Research Collaborative (STORK). Prospective risk of late stillbirth in monochorionic twins: a regional cohort study. Ultrasound Obstet Gynecol. 2012;39(5):500–4.

    Article  Google Scholar 

  29. Hack KEA, Derks JB, Elias SG, et al. Perinatal mortality and mode of delivery in monochorionic twin pregnancies ≥32 weeks of gestation: a multicenter retrospective cohort study. BJOG. 2011;118(9):1090–7.

    Article  CAS  Google Scholar 

  30. Van Mieghem T, De Heus R, Lewi L, et al. Prenatal management of monoamniotic twin pregnancies. Obstet Gynecol. 2014;124:498–506.

    Article  Google Scholar 

  31. Ishii K. Prenatal diagnosis and management of monoamniotic twins. Curr Opin Obstet Gynecol. 2015;27(2):159–64.

    Article  Google Scholar 

  32. Curado J, D’Antonio F, Papageorghiou AT, Bhide A, Thilaganathan B, Khalil A. Perinatal mortality and morbidity in triplet pregnancy according to chorionicity: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2019;54(5):589–95.

    Article  CAS  Google Scholar 

  33. Ko HS, Choi SK, Wie JH, Park IY, Park YG, Shin JC. Optimal timing of delivery based on the risk of stillbirth and infant death associated with each additional week of expectant management in multiple pregnancies: a national cohort study of Koreans. J Korean Med Sci. 2018;33(10):e80.

    Article  Google Scholar 

  34. Kawaguchi H, Ishii K, Yamamoto R, Hayashi S, Mitsuda N, Perinatal Research Network Group in Japan. Perinatal death of triplet pregnancies by chorionicity. AJOG. 2013;209:36.e1–7.

    Article  Google Scholar 

Key Reading

  • Cheong-See F, Schuit E, Arroyo-Manzano D, Khalil A, Barrett J, Joseph KS, et al. Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis. BMJ. 2016;354:i4353. https://doi.org/10.1136/bmj.i4353.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dias T, Akolekar R. Timing of birth in multiple pregnancy. Best Pract Res Clin Obstet Gynaecol. 2014;28(2):319–26.

    Article  Google Scholar 

  • Hack KEA, Derks JB, Elias SG, et al. Increased perinatal mortality and morbidity in monochorionic versus dichorionic twin pregnancies: clinical implications of a large Dutch cohort study. BJOG. 2008;115:58–67.

    Article  CAS  Google Scholar 

  • Hack KEA, Derks JB, Elias SG, et al. Perinatal mortality and mode of delivery in monochorionic twin pregnancies ≥32 weeks of gestation: a multicenter retrospective cohort study. BJOG. 2011;118(9):1090–7.

    Article  CAS  Google Scholar 

  • National Institute for Health and Clinical Excellence. Twin and triplet pregnancy. NICE clinical guideline 137. London: National Institute for Health and Clinical Excellence; 2019.

    Google Scholar 

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Correspondence to Asma Khalil .

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Liu, B., Khalil, A. (2021). Timing of Birth in Uncomplicated Twin Pregnancy. In: Khalil, A., Lewi, L., Lopriore, E. (eds) Twin and Higher-order Pregnancies. Springer, Cham. https://doi.org/10.1007/978-3-030-47652-6_20

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  • DOI: https://doi.org/10.1007/978-3-030-47652-6_20

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-47651-9

  • Online ISBN: 978-3-030-47652-6

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