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Biological Signalling

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Bioinformatics

Part of the book series: Computational Biology ((COBO))

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Abstract

This chapter is primarily concerned with signal transduction within cells: how information about a cell’s environment is transferred from the external cell surface to its nucleus, where it affects changes in gene expression appropriate to changes detected in the environment. Signal channel capacities are discussed, and the molecular mechanisms of the transduction process.

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Notes

  1. 1.

    Individual cells can communicate with their nearest neighbours via the so-called gap junctions.

  2. 2.

    Krauss (2008), Péter et al. (2021).

  3. 3.

    Hlavacek et al. (2006).

  4. 4.

    E.g., Fisher et al. (2000), Akhtar and Gasser (2007).

  5. 5.

    Forgacs (1995), Shafrir et al. (2000).

  6. 6.

    There is some arbitrariness in the deduction of amplification factors. For example, if the metabolite coursing in human blood caused its host to operate a lever in a factory producing epinephrine, the factor might be many, many orders of magnitude greater.

  7. 7.

    The blowfly photoreceptor was analysed along these lines by Abshire and Andreou in 2001.

  8. 8.

    Ashby (1958).

  9. 9.

    E.g., Ramsden and Vohradský (1998).

  10. 10.

    Thomas and Eckford (2016), Eckford and Thomas (2018); see also Tkačik and Bialek (2016).

  11. 11.

    Blumenfeld (1981).

  12. 12.

    Blake et al. (2003), Raser and O’Shea (2005).

References

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Authors and Affiliations

  1. Department of Biomedical Research, The University of Buckingham, Buckingham, UK

    Jeremy Ramsden

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  1. Jeremy Ramsden
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Correspondence to Jeremy Ramsden .

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Ramsden, J. (2023). Biological Signalling. In: Bioinformatics. Computational Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-45607-8_22

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  • DOI: https://doi.org/10.1007/978-3-030-45607-8_22

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-45606-1

  • Online ISBN: 978-3-030-45607-8

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