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Diplopia and Strabismus

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Albert and Jakobiec's Principles and Practice of Ophthalmology
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Abstract

Several requirements are necessary for single visual images. Individuals with normal retinal correspondence and aligned eyes have single vision. Anomalous retinal correspondence occurs to restore crude binocularity when the eyes are not able to work together via sensory and motor fusion. Central fusion results when an image falls on corresponding retinal points within the fovea. Peripheral fusion occurs in response to images falling on corresponding retinal areas within the extrafoveal retinal periphery. Sensory fusion refers to binocular single vision. Motor fusion is the ability to align the eyes so that sensory fusion is maintained. Suppression is strictly limited to binocular vision, an adaptation to avoid diplopia and confusion. Binocular diplopia is a normal, physiologically correct response and happens when identical objects are imaged on disparate retinal areas. Monocular diplopia may occur from anomalies of the ocular media, in the presence of optical aberrations, due to cortical dysfunction, or due to sensory anomalies. Physiologic diplopia is a normal response to binocular vision and serves as evidence of normal cooperation of the two eyes. Paradoxical diplopia takes place in the presence of persistent anomalous retinal correspondence after strabismus surgery. It usually resolves within days to weeks. Binocular triplopia exists when the fovea of one eye localizes one visual object simultaneously in two visual directions while viewing the object with both eyes at the same time. Confusion develops when two different objects are imaged on corresponding retinal areas and perceived concurrently by the brain. Strabismus, with or without diplopia, can negatively impact the psychosocial health and quality of life of an individual. Treatment for double vision may be surgical or nonsurgical, and the treatment method applied depends on multiple factors such as the characteristics of the diplopia, presence or absence of extraocular muscle paralysis, and patient preference. Nonsurgical treatment options include occlusion and prisms. If systemic disease such as myasthenia is present, this should be addressed. Surgical treatment options include botulinum toxin injections and eye muscle surgery, which may involve transposition procedures, adjustable sutures, and oblique muscle surgery. Careful preoperative evaluation is crucial, and both forced duction testing and mapping of the deviation using Lancaster red-green or Hess screen evaluation may be helpful.

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References

  1. Wong AM, Leuder GT, Burkhalter A, Tychsen L. Anomalous retinal correspondence: neuroanatomic mechanism in strabismic monkeys and clinical findings in strabismic children. J AAPOS. 2000;4:168–74.

    Article  CAS  PubMed  Google Scholar 

  2. von Noorden GK, Campos EC. Binocular vision and ocular motility. In: Theory and management of strabismus. 6th ed. St. Louis: Mosby; 2002. p. 7–37, 127–133, 211–245.

    Google Scholar 

  3. Bishop PO. Binocular vision. In: Moses RA, editor. Adler’s physiology of the eye. Saint Louis: The C.V. Mosby Company; 1981. p. 575–649.

    Google Scholar 

  4. Parks MM. Single binocular vision. In: Tasman W, Jaeger EA, editors. Duane’s clinical ophthalmology. Philadelphia: Lippincott-Raven; 1996. p. 1–13.

    Google Scholar 

  5. Wang FM, Chryssanthou G. Monocular eye closure in intermittent exotropia. Arch Ophthalmol. 1988;106:941–2.

    Article  CAS  PubMed  Google Scholar 

  6. Harms H. Ort und Wesen der Bildhemmung bei Schielenden. Graefes Arch Clin Exp Ophthalmol. 1938;138:149.

    Article  Google Scholar 

  7. Sireteanu R. Binocular vision in strabismic humans with alternating fixation. Vis Res. 1982;22:889.

    Article  CAS  PubMed  Google Scholar 

  8. Travers TB. Suppression of vision in squint and its association with retinal correspondence and amblyopia. Br J Ophthalmol. 1938;22:577.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Holopigian K, Blake R, Greenwald MJ. Clinical suppression and amblyopia. Invest Ophthalmol Vis Sci. 1988;29:444–51.

    CAS  PubMed  Google Scholar 

  10. Agrawal R, Conner IP, Odom JV, et al. Relating binocular and monocular vision in strabismic and anisometropic amblyopia. Arch Ophthalmol. 2006;124:84–50.

    Article  Google Scholar 

  11. Wong AM, Burkhaltar A, Tychsen L. Suppression of metabolic activity caused by infantile strabismus and strabismic amblyopia in striate visual cortex of macaque monkeys. J AAPOS. 2005;9:37–47.

    Article  PubMed  Google Scholar 

  12. Thiele A, Bremmer F, Ilg UJ, Hoffmann KP. Visual responses of neurons from areas VI and MT in a monkey with late onset strabismus: a case study. Vis Res. 1997;37:853–63.

    Article  CAS  PubMed  Google Scholar 

  13. Javal E. De quelques phenomènes de diplopie chez certains strabiques. Ann Ocul. 1865;54:123.

    Google Scholar 

  14. Bielschowsky A. Über monoculäre Diplopie ohne physikalische Grundlage, nebst Bemerkungen über das Sehen Schielender 1898; 46:143.

    Google Scholar 

  15. Saunders M, Guinane C, MacFarlane M, et al. A diplopia dilemma. Surv Ophthalmol. 2006;51:68–74.

    Article  PubMed  Google Scholar 

  16. Spector RH. Vertical diplopia. Surv Ophthalmol. 1993;38:31–62.

    Article  CAS  PubMed  Google Scholar 

  17. Comer RM, Dawson E, Plant G, Acheson JF, Lee JP. Causes and outcomes for patients presenting with diplopia to an eye casualty department. Eye. 2007;21:413–8.

    Google Scholar 

  18. Kushner BJ. Recently acquired diplopia in adults with long-standing strabismus. Arch Ophthalmol. 2001;119:1795–801.

    Article  CAS  PubMed  Google Scholar 

  19. Kushner BJ. Fixation switch diplopia. Arch Ophthalmol. 1995;113:896–9.

    Article  CAS  PubMed  Google Scholar 

  20. Boyd TA, Karas Y, Budd GE, Wyatt HT. Fixation switch diplopia. Can J Ophthalmol. 1974;9:310–5.

    CAS  PubMed  Google Scholar 

  21. Sherafat H, White JE, Pullum KW, et al. Anomalies of binocular function in patients with longstanding asymmetric keratoconus. Br J Ophthalmol. 2001;85:1057–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Yanguela J, Gomez-Arnau JI, Martin-Rodrigo JC, et al. Diplopia after cataract surgery: comparative results after topical or regional injection anesthesia. Ophthalmology. 2004;111:686–92.

    Article  PubMed  Google Scholar 

  23. Johnson DA. Persistent vertical diplopia after cataract surgery. Am J Ophthalmol. 2001;132:831–5.

    Article  CAS  PubMed  Google Scholar 

  24. MacDonadl IM, Reed GF, Wakeman BJ. Strabismus after regional anesthesia for cataract surgery. Can J Ophthalmol. 2004;39:267–17.

    Article  Google Scholar 

  25. Schwarz EC, Gerdemann M, Hoffmann R, Hartmann C. Strabismus and diplopia as complications after cataract surgery with IOL implantation. Ophthalmologe. 1999;96:635–9.

    Article  CAS  PubMed  Google Scholar 

  26. Hunter DG, Lam GC, Guyton DL. Inferior oblique muscle injury from local anesthesia for cataract surgery. Ophthalmology. 1996;103:545–6.

    Google Scholar 

  27. Yap EY, Kowal L. Diplopia as a complication of laser in situ keratomileusis surgery. Clin Exp Ophthalmol. 2001;29:268–71.

    Article  CAS  PubMed  Google Scholar 

  28. Snir M, Kremer I, Weinberger D, et al. Decompensation of exodeviation after corneal refractive surgery for moderate to high myopia. Ophthalmic Surg Lasers Imaging. 2003;34:363–70.

    Article  PubMed  Google Scholar 

  29. Chung S, Kim W, Moon J, et al. Impact of laser refractive surgery on ocular alignment in myopic patients. Eye. 2014;28(11):1321–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Schuler E, Silverberg M, Beade P, Moadel K. Decompensated strabismus after laser in situ keratomileusis. J Cataract Refract Surg. 1999;25:1552–3.

    Article  CAS  PubMed  Google Scholar 

  31. Godts D, Tassignon MJ, Gobin L. Binocular vision impairment after refractive surgery. J Cataract Refract Surg. 2004;30:101–9.

    Article  PubMed  Google Scholar 

  32. Kushner BJ, Kowal L. Diplopia after refractive surgery: occurrence and prevention. Arch Ophthalmol. 2003;121:315–21.

    Article  PubMed  Google Scholar 

  33. De Pool ME, Campbell JP, Broome SO, Guyton DL. The dragged-fovea diplopia syndrome: clinical characteristics, diagnosis, and treatment. Ophthalmology. 2005;112:1455–62.

    Article  PubMed  Google Scholar 

  34. Benegas NM, Egbert J, Engel WK, Kushner BJ. Diplopia secondary to aniseikonia associated with macular disease. Arch Ophthalmol. 1999;117:896–9.

    Article  CAS  PubMed  Google Scholar 

  35. Brazis PW, Lee AG, Bolling JP. Binocular vertical diplopia due to subretinal nonvascular membrane. Strabismus. 1998;6:127–31.

    Article  CAS  PubMed  Google Scholar 

  36. Foroozan R, Arnold AC. Diplopia after cataract surgery. Surv Ophthalmol. 2005;50:81–4.

    Article  PubMed  Google Scholar 

  37. Bixenman WW, Joffee L. Binocular diplopia associated with retinal wrinkling. J Pediatr Ophthalmol Strabismus. 1984;21:215–9.

    Article  CAS  PubMed  Google Scholar 

  38. Burgess D, Roper-Hall G, Burde RM. Binocular diplopia associated with subretinal neovascular membranes. Arch Ophthalmol. 1980;98:311–7.

    Article  CAS  PubMed  Google Scholar 

  39. Schroeder B, Krzizok T, Kaufmann H, Kroll P. Disturbances of binocular vision in macular heterotopia. Klin Monatsbl Augenheilkd. 1999;215:135–9.

    Article  CAS  PubMed  Google Scholar 

  40. Barton JJ. ‘Retinal diplopia’ associated with macular wrinkling. Neurology. 2004;63:925–7.

    Article  PubMed  Google Scholar 

  41. Fison PN, Chignell AH. Diplopia after retinal detachment surgery. Br J Ophthalmol. 1987;71:521–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Langmann A, Gruber A, Lindner S, Langmann G. Diplopia after encircling procedure for retinal detachment. Ophthalmologe. 2003;100:623–7.

    Article  CAS  PubMed  Google Scholar 

  43. Wright LA, Cleary M, Barrie T, Hammer HM. Motility and binocularity outcomes in vitrectomy versus scleral bucking in retinal detachment surgery. Graefes Arch Clin Exp Ophthalmol. 1999;237:1028–32.

    Article  CAS  PubMed  Google Scholar 

  44. Buffenn AN, de Juan E, Fujii G, Hunter DG. Diplopia after limited macular translocation surgery. J AAPOS. 2001;5:388–94.

    Article  CAS  PubMed  Google Scholar 

  45. Eckardt U, Eckardt C. Orthoptic problems after macular rotation with and without muscle surgery. Klin Monatsbl Augenheilkd. 1998;212:212–7.

    Article  CAS  PubMed  Google Scholar 

  46. Digout LG, Awad AH. Restoration of binocular single vision after long-term fusion disruption. J AAPOS. 2003;7:185–9.

    Article  PubMed  Google Scholar 

  47. Rutstein RP, Cogen MS. Elimination of paradoxical diplopia following treatment with botulinum toxin and prism. Binocul Vis Strabismus Q. 2004;19:35–8.

    PubMed  Google Scholar 

  48. Lee MS, Volpe NJ. Double Vision. Curr Treat Options Neurol. 2001;3:383–8.

    Article  PubMed  Google Scholar 

  49. Coffen P, Guyton D. Monocular diplopia accompanying ordinary refractive errors. Am J Ophthalmol. 1988;105:451.

    Article  Google Scholar 

  50. Ford JG, Davis RM, Reed JW, et al. Bilateral monocular diplopia associated with lid position during near work. Cornea. 1997;16:525–30.

    CAS  PubMed  Google Scholar 

  51. Takei K. Is abnormal focal steepening of the cornea related to persistent monocular diplopia? J Refract Surg. 2002;18:253–62.

    Article  PubMed  Google Scholar 

  52. Kraft H. Monocular double images caused by constriction of the posterior lens surface due to a string of vitreous body following perforating eyeball injuries. Ber Zusammenkunft Dtsch Ophthalmol Ges. 1968;68:427–9.

    CAS  PubMed  Google Scholar 

  53. Records RE. Monocular diplopia. Surv Ophthalmol. 1980;24:303–6.

    Article  CAS  PubMed  Google Scholar 

  54. Helbig H, Ruesch R. Double vision caused by double intraocular lenses. Ophthalmologe. 2000;97:781–3.

    Article  CAS  PubMed  Google Scholar 

  55. Kommerell G. Monocular diplopia caused by pressure of the upper eyelid on the cornea. Diagnosis based on the ‘Venetian blind phenomenon’ in streak retinoscopy. Klin Monatsbl Augenheilkd. 1993;203:384–9.

    Article  CAS  PubMed  Google Scholar 

  56. Melamud A, Chalita MR, Krueger RR, Lee MS. Comatic aberration as a cause of monocular diplopia. J Cataract Refract Surg. 2006;32:529–32.

    Article  PubMed  Google Scholar 

  57. Fujikado T, Shimojyo H, Hosohata J, et al. Wavefront analysis of eye with monocular diplopia and cortical cataract. Am J Ophthalmol. 2006;141:1138–40.

    Article  PubMed  Google Scholar 

  58. Rubin ML. Optics for clinicians. 2nd ed. Gainesville: Triad Scientific Publishers; 1977. p. 185–8, 308.

    Google Scholar 

  59. Nagy V, Modis L, Kertesz K, et al. Anterior polar cataract as a cause of monocular diplopia. J Cataract Refract Surg. 2004;30:1596–7.

    Article  PubMed  Google Scholar 

  60. Garcia Medina JJ, Garcia Medina M, Pinazo Duran MD, Suarez-Varela MM. Monocular diplopia after neodymium: YAG laser capsulotomy. Graefes Arch Clin Exp Ophthalmol. 2005;243:1288–90.

    Article  PubMed  Google Scholar 

  61. Takei K, Sano Y, Achiron LR, et al. Monocular diplopia related to asymmetric corneal topography after laser in situ keratomileusis. J Refract Surg. 2001;17:652–7.

    Article  CAS  PubMed  Google Scholar 

  62. Miller NR, Newman NJ. Walsh and Hoyt’s clinical neuro-ophthalmology the essentials. 5th ed. Baltimore: Williams and Wilkins; 1999. p. 782–3.

    Google Scholar 

  63. Kompf D, Piper HF, Neundorfer B, Dietrich H. Palinopsia (visual preservation) and cerebral polyopia-clinical analysis and computed tomographic findings. Fortschr Neurol Psychiatr. 1983;51:270–81.

    Article  CAS  PubMed  Google Scholar 

  64. Cornblath WT, Butter CM, Barnes LL, Hasselbach MM. Spatial characteristics of cerebral polyopia: a case study. Vis Res. 1998;38:3965–78.

    Article  CAS  PubMed  Google Scholar 

  65. Jones MR, Waggoner R, Hoyt WF. Cerebral polyopia with extrastriate quadrantanopia: report of a case with magnetic resonance documentation of V2/V3 cortical infraction. J Neuroophthalmol. 1999;19:1–6.

    Article  CAS  PubMed  Google Scholar 

  66. Cracket P, Weir C, Houston CA. Transient monocular diplopia resulting from the treatment of amblyopia. J Pediatr Ophthalmol Strabismus. 2003;40:245–6.

    Article  Google Scholar 

  67. Lang J, Huber C. Binocular triplopia induced by weak prisms. Albercht Von Graefes Arch Klin Exp Ophthalmol. 1977;204:39–44.

    Article  CAS  Google Scholar 

  68. McBain HB, Au CK, Hancox J, et al. The impact of strabismus on quality of life in adults with and without diplopia. Surv Ophthalmol. 2014;59:185–91.

    Article  PubMed  Google Scholar 

  69. Mohney BG, Mckenzie JA, Capo JA, et al. Mental illness in young adults who had strabismus as children. Pediatrics. 2008;122(5):1033–8.

    Article  PubMed  Google Scholar 

  70. Mckenzie J, Capo J, Nusz K, et al. Prevalence and sex differences of psychiatric disorders in young adults who had intermittent exotropia as children. Arch Ophthalmol. 2009;127(6):743–7.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Akay AP, Cakaloz B, Berk AT, et al. Psychosocial aspects of mothers of children with strabismus. J AAPOS. 2005;9(3):268–73.

    Article  PubMed  Google Scholar 

  72. Yamada T, Hatt S, Leske DA, et al. Health-related quality of life in parents of children with intermittent exotropia. J AAPOS. 2011;15(2):135–9.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Olitsky SE, Sudesh S, Graziano A, et al. The negative psychosocial impact of strabismus in adults. J APPOS. 1999;3(4):209–11.

    CAS  Google Scholar 

  74. Coats DK, Paysse EA, Towler AJ, et al. Impact of large angle horizontal strabismus on ability to obtain employment. Ophthalmology. 2000;107(2):402–5.

    Article  CAS  PubMed  Google Scholar 

  75. Silverberg M, Schuler E, Veronneau-Troutman S, et al. Nonsurgical management of binocular diplopia induced by macular pathology. Arch Ophthalmol. 1999;117:900–3.

    Article  CAS  PubMed  Google Scholar 

  76. Kupersmith MJ, Ying G. Ocular motor dysfunction and ptosis in ocular myasthenia gravis: effects of treatment. Br J Ophthalmol. 2005;89:1330–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Woo GC, Lovasik JV. Fresnel prism correction for trauma-induced diplopia. Ophthalmic Physiol Opt. 1985;5:59–62.

    Article  CAS  PubMed  Google Scholar 

  78. Awadein A, Pesheva M, Guyton DL. Inverted brown pattern: a tight inferior oblique muscle masquerading as a superior oblique muscle underaction-clinical characteristics and surgical management. J AAPOS. 2006;10:565–72.

    Article  PubMed  Google Scholar 

  79. Woo SJ, Seo JM, Hwang JM. Clinical characteristic of cyclodeviation. Eye. 2005;19:873–8.

    Article  PubMed  Google Scholar 

  80. Phillips PH, Hunter DG. Evaluation of ocular torsion and principles of management. In: Rosenbaum AL, Santiago AP, editors. Clinical strabismus management principles and surgical techniques. Philadelphia: W.B. Saunders Company; 1999. p. 52–72.

    Google Scholar 

  81. Eustis HS, Nussdorf JD. Inferior oblique overaction in infantile esotropia: fundus extorsion as a predictive sign. J Pediatr Ophthalmol Strabismus. 1996;33:85–8;74.

    Article  CAS  PubMed  Google Scholar 

  82. Sterker I, Wolf S, Wiedemann P. Strabological results in patients with macular translocation surgery and counterrotation of the globe as a secondary procedure. Strabismus. 2002;10:111–7.

    Article  PubMed  Google Scholar 

  83. Freedman SF, Holgado S, Enyedi LB, Toth CA. Management of ocular torsion and diplopia after macular translocation for age-related macular degeneration: prospective clinical study. Am J Ophthalmol. 2003;136:640–8.

    Article  PubMed  Google Scholar 

  84. Klainguti G, Nguyen C. Surgical management of monocular torsion and head tilt after macular translocation. Klin Monatsbl Augenheilkd. 2005;222:222–5.

    Article  CAS  PubMed  Google Scholar 

  85. Buffenn A. Adjustable suture use in strabismus surgery. Curr Opin Ophthalmol. 2005;16:294–7.

    Article  PubMed  Google Scholar 

  86. Awadein A, Sharma M, Bazemore MG, Saeed HA, Guyton DL. Adjustable suture strabismus surgery in infants and children. J AAPOS. 2008;12(6):585–90.

    Article  PubMed  Google Scholar 

  87. Kassem A, Xue G, Gandhi NB, Tian J, Guyton DL. Adjustable suture strabismus surgery in infants and children: a 19-year experience. J AAPOS. 2018;22(3):174–8.

    Article  PubMed  Google Scholar 

  88. Velez FG, Chan TK, Vives T, et al. Timing of postoperative adjustment in adjustable suture strabismus surgery. J AAPOS. 2001;5:178–83.

    Article  CAS  PubMed  Google Scholar 

  89. Spierer A. Adjustment of sutures 8 hours vs 24 hours after strabismus surgery. Am J Ophthalmol. 2000;129:521–4.

    Article  CAS  PubMed  Google Scholar 

  90. Bleik JH, Karam VY. Comparison of the immediate with the 24-hour postoperative prism and cover measurement in adjustable muscle surgery: is immediate postoperative adjustment reliable? J AAPOS. 2004;8:528–33.

    Article  PubMed  Google Scholar 

  91. Ben Simon GJ, Wang L, McCann JD, Goldberg RA. Primary-gaze diplopia in patients with thyroid-related orbitopathy undergoing deep lateral orbital decompression with intraconal fat debulking: a retrospective analysis of treatment outcome. Thyroid. 2004;14:379–83.

    Article  PubMed  Google Scholar 

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Buffenn, A.N. (2022). Diplopia and Strabismus. In: Albert, D.M., Miller, J.W., Azar, D.T., Young, L.H. (eds) Albert and Jakobiec's Principles and Practice of Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-030-42634-7_291

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