Skip to main content
SpringerLink
Log in

Liver Tumours: The African Perspective

  • Chapter
  • First Online:
Pediatric Surgery

  • 125 Accesses

Abstract

Primary tumours of the liver are rare in childhood and comprise 0.8–1% of all pediatric tumours. Malignant tumours are more common (65% of primary liver tumours). An overview of both malignant and benign liver tumours will be given with a focus on clinical presentation and treatment options in the African setting.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Moore SW, Davidson A, Hadley GP, Kruger M, Poole J, Stones D, Wainwright L, Wessels G. Malignant liver tumors in South African children: a national audit. World J Surg. 2008;32:1389–95.

    CAS  PubMed  Google Scholar 

  2. Darbari A, Sabin KM, Shapiro CN, Schwarz KB. Epidemiology of primary hepatic malignancies in U.S. children. Hepatology. 2003;38:560–6.

    PubMed  Google Scholar 

  3. McLaughlin CC, Baptiste MS, Schymura MJ, Nasca PC, Zdeb MS. Maternal and infant birth characteristics and hepatoblastoma. Am J Epidemiol. 2006;163:818–28.

    PubMed  Google Scholar 

  4. Kew MC. Prevention of hepatocellular carcinoma. HPB (Oxford). 2005;7:16–25.

    Google Scholar 

  5. Czauderna P, Lopez-Terrada D, Hiyama E, Häberle B, Malogolowkin MH, Meyers RL. Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy. Curr Opin Pediatr. 2014;26:19–28.

    CAS  PubMed  Google Scholar 

  6. Hadley GP, Govender D, Landers G. Primary tumours of the liver in children: an African perspective. Pediatr Surg Int. 2004;20:314–8.

    CAS  PubMed  Google Scholar 

  7. Czauderna P. Adult type vs. childhood hepatocellular carcinoma--are they the same or different lesions? Biology, natural history, prognosis, and treatment. Med Pediatr Oncol. 2002;39:519–23.

    CAS  PubMed  Google Scholar 

  8. Isaacs H Jr. Fetal and neonatal hepatic tumors. J Pediatr Surg. 2007;42:1797–803.

    PubMed  Google Scholar 

  9. Catanzarite V, Hilfiker M, Daneshmand S, Willert JJ. Prenatal diagnosis of fetal hepatoblastoma: case report and review of the literature. Ultrasound Med. 2008;27:1095–8.

    Google Scholar 

  10. Hall GW. Kasabach-Merritt syndrome: pathogenesis and management. Br J Haematol. 2001;112:851–62.

    CAS  PubMed  Google Scholar 

  11. Bader D, Riskin A, Vafsi O, Tamir A, Peskin B, Israel N, Merksamer R, Dar H, David M. Alpha-fetoprotein in the early neonatal period--a large study and review of the literature. Clin Chim Acta. 2004;349:15–23.

    CAS  PubMed  Google Scholar 

  12. Von Schweinitz D. Management of liver tumors in childhood. Semin Pediatr Surg. 2006;15:17–24.

    Google Scholar 

  13. Von Schweinitz D, Burger D, Mildenberger H. Is laparatomy the first step in treatment of childhood liver tumors?--the experience from the German Cooperative Pediatric Liver Tumor Study HB-89. Eur J Pediatr Surg. 1994;4:82–6.

    Google Scholar 

  14. Roebuck DJ, Aronson DC, Clapuyt P, Czauderna P, de Ville de Goyet J, Gauthier F, MacKinlay G, Maibach R, McHugh K, Olsen OE, Otte J-B, Pariente D, Plaschkes J, Childs M, Perilongo G. 2005 PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group. Pediatr Radiol. 2007;37:123–32.

    PubMed  Google Scholar 

  15. Aronson DC, Czauderna P, Maibach R, Perilongo G, Morland B. The treatment of hepatoblastoma: its evolution and the current status as per the SIOPEL trials. J Indian Assoc Pediatr Surg. 2014;19:201–7.

    PubMed  PubMed Central  Google Scholar 

  16. Perilongo G, Shafford E, Maibach R, Aronson DC, Brugieres L, Brock P, Childs M, Czauderna P, MacKinlay G, Otte J-B, Pritchard J, Rondelli R, Scopinaro M, Staalman C, Plaschkes J. Risk-adapted treatment for childhood hepatoblastoma. Final report of the second study of the International Society of Pediatric Oncology–SIOPEL 2. Eur J Cancer. 2004;40:411–21.

    Google Scholar 

  17. Perilongo G, Maibach R, Shafford E, Brugieres L, Brock P, Morland B, de Camargo B, Zsiros J, Roebuck D, Zimmermann A, Aronson DC, Childs M, Widing E, Laithier V, Plaschkes J, Pritchard J, Scopinaro M, MacKinlay G, Czauderna P. Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma. N Engl J Med. 2009;361:1662–70.

    CAS  PubMed  Google Scholar 

  18. Zsíros J, Maibach R, Shafford E, Brugieres L, Brock P, Czauderna P, Roebuck D, Childs M, Zimmermann A, Laithier V, Otte J-B, de Camargo B, MacKinlay G, Scopinaro M, Aronson DC, Plaschkes J, Perilongo G. Successful treatment of childhood high-risk Hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study. J Clin Oncol. 2010;28:2584–90.

    PubMed  Google Scholar 

  19. Zsiros J, Brugieres L, Brock P, Roebuck D, Maibach R, Zimmermann A, Childs M, Pariente D, Laithier V, Otte J-B, Branchereau S, Aronson DC, Rangaswami A, Ronghe M, Casanova M, Sullivan M, Morland B, Czauderna P, Perilongo G. Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study. Lancet Oncol. 2013;14:834–42.

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Aronson DC, Meyers RL. Malignant tumors of the liver in children. Semin Pediatr Surg. 2016;25:265–75.

    PubMed  Google Scholar 

  21. Otte J-B, Pritchard J, Aronson DC, Brown J, Czauderna P, Maibach R, Perilongo G, Shafford E, Plaschkes J. Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. Pediatr Blood Cancer. 2004;42:74–83.

    CAS  PubMed  Google Scholar 

  22. Czauderna P, Otte J-B, Aronson DC, Gauthier F, MacKinlay G, Roebuck D, Plaschkes J, Perilongo G. Guidelines for surgical treatment of hepatoblastoma in the modern era–recommendations from the childhood liver tumour strategy Group of the International Society of Pediatric Oncology (SIOPEL). Eur J Cancer. 2005;41:1031–6.

    Google Scholar 

  23. Moore SW, Millar AJ, Hadley GP, Ionescu G, Kruger M, Poole J, Stones D, Wainwright L, Chitnis M, Wessels G. Hepatocellular carcinoma and liver tumors in South African children: a case for increased prevalence. Cancer. 2004;101:642–9.

    PubMed  Google Scholar 

  24. Murawski M, Weeda VB, Maibach R, Morland B, Roebuck DJ, Zimmerman A, Casanova M, Perilongo G, Laithier V, Kebudi R, Scopinaro MJ, Shun A, Brichard B, de Camargo B, Childs M, Aronson DC, Czauderna P. Hepatocellular carcinoma in children: does chemotherapy intensification change the outcome? Lessons learnt from the SIOPEL 2 and 3 studies. J Clin Oncol. 2016;34:1050–6.

    CAS  PubMed  Google Scholar 

  25. Merli L, Mussini C, Gabor F, Branchereau S, Martelli H, Pariente D, Guérin F. Pitfalls in the surgical management of undifferentiated sarcoma of the liver and benefits of preoperative chemotherapy. Eur J Pediatr Surg. 2015;25:132–7.

    PubMed  Google Scholar 

  26. Chowdhary SK, Trehan A, Das A, Marwaha RK, Rao KL. Undifferentiated embryonal sarcoma in children: beware of the solitary liver cyst. J Pediatr Surg. 2004;39:E9–12.

    CAS  PubMed  Google Scholar 

  27. Charfi S, Ayadi L, Toumi N, Frikha F, Daoud E, Makni S, Frikha M, Beyrouti MI, Sellami-Boudawara T. Cystic undifferentiated sarcoma of liver in children: a pitfall diagnosis in endemic hydatidosis areas. J Pediatr Surg. 2008;43:E1–4.

    PubMed  Google Scholar 

  28. Bisogno G, Pilz T, Perilongo G, Ferrari A, Harms D, Ninfo V, Treuner J, Carli M. Undifferentiated sarcoma of the liver in childhood: a curable disease. Cancer. 2002;94:252–7.

    PubMed  Google Scholar 

  29. Burrows PE, Dubois J, Kassarjian A. Pediatric hepatic vascular anomalies. Pediatr Radiol. 2001;31:533–45.

    CAS  PubMed  Google Scholar 

  30. Prokurat A, Kluge P, Chrupek M, et al. Hemangioma of the liver in children: proliferating vascular tumor or congenital vascular malformation. Med Pediatr Oncol. 2002;39:524–9.

    PubMed  Google Scholar 

  31. Christison-Lagay ER, Burrows PE, Alomari A, Dubois J, Kozakewich HP, Lane TS, Paltiel HJ, Klement G, Mulliken JB, Fishman SJ. Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediat Surg. 2007;42:62–7.

    PubMed  Google Scholar 

  32. Selby DM, Stocker JT, Waclawiw MA, et al. Infantile hemangioendothelioma of the liver. Hepatology. 1994;20:39–45.

    CAS  PubMed  Google Scholar 

  33. Siddiqui MA, McKenna BJ. Hepatic mesenchymal hamartoma: a short review. Arch Pathol Lab Med. 2006;130:1567–9.

    PubMed  Google Scholar 

  34. Stringer MD, Alizai NK. Mesenchymal hamartoma of the liver: a systematic review. J Pediatr Surg. 2005;40:1681–90.

    PubMed  Google Scholar 

  35. Meinders AJ, Simons MP, Heij HA, Aronson DC. Mesenchymal hamartoma of the liver: failed management by marsupialization. J Pediatr Gastroenterol Nutr. 1998;26:353–5.

    CAS  PubMed  Google Scholar 

  36. Rogers TN, Woodley H, Ramsden W, Wyatt JI, Stringer MD. Solitary liver cysts in children: not always so simple. J Pediatr Surg. 2007;42:333–9.

    PubMed  Google Scholar 

  37. Sandler A, Kimura K, Soper R. Nonanatomic hepatic resection with a pledgetted suturing technique. J Pediatr Surg. 2001;36:209–12.

    CAS  PubMed  Google Scholar 

  38. Yigitler C, Farges O, Kianmanesh R, Regimbeau JM, Abdalla EK, Belghiti J. The small remnant liver after major liver resection: how common and how relevant? Liver Transpl. 2003;9:S18–25.

    PubMed  Google Scholar 

  39. Goldstein ST, Alter MJ, Williams IT, Moyer LA, Judson FN, Mottram K, Fleenor M, Ryder PL, Margolis HS. Incidence and risk factors for acute hepatitis B in the United States, 1982-1998: implications for vaccination programs. J Infect Dis. 2002;185:713–9.

    PubMed  Google Scholar 

  40. Goldstein ST, Zhou F, Hadler SC, Bell BP, Mast EE, Margolis HS. A mathematical model to estimate global hepatitis B disease burden and vaccination impact. Int J Epidemiol. 2005;34:1329–39.

    PubMed  Google Scholar 

  41. Shatat H, Kotkat A, Farghaly A, Omar S, Zayton S. A study of hepatitis B vaccine efficacy 10 years after compulsory vaccination in Egypt. J Egypt Public Health Assoc. 2005;80:495–508.

    PubMed  Google Scholar 

  42. Viviani S, Carrieri P, Bah E, Hall AJ, Kirk GD, Mendy M, Montesano R, Plymoth A, Sam O, Van der Sande M, Whittle H, Hainaut P. 20 years into the Gambia Hepatitis Intervention Study: assessment of initial hypotheses and prospects for evaluation of protective effectiveness against liver cancer. Cancer Epidemiol Biomarkers Prev. 2008;17(11):3216–23.

    PubMed  Google Scholar 

  43. Finegold MJ, Egler RA, Goss JA, Guillerman RP, Karpen SJ, Krishnamurthy R, O'Mahony CA. Liver tumors: pediatric population. Liver Transpl. 2008;14:1545–56.

    PubMed  Google Scholar 

  44. Cayrol J, Trobaugh-Lotrario AD, O’Neill AF, Weeda V, Rangaswami AA, Aronson DC, Brock P, Davidson A, Morland B, Czauderna P, Leal C, Ronghe M, Veintemilla G, Malogolowkin M, Towbin AJ, Sullivan MJ. SIOP Pediatric Oncology in Developing Countries (PODC) Adapted Treatment Regimen and Recommendation for the diagnosis and treatment of Hepatoblastoma in Low and Middle-Income Settings. Pediatric Blood Canc 2020, in press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Surgery, University Children’s Hospital Zürich, Zürich, Switzerland

    Daniel C. Aronson

  2. Department of Surgery, University of the Witwatersrand and Chris Hani Baragwanath Hospital, Johannesburg, South Africa

    Graeme Pitcher

  3. Department of Pediatric Surgery, John Radcliffe Hospital, Oxford, UK

    V. T. Joseph

  4. University of Oxford and Oxford University Hospitals, Oxford, UK

    Kokila Lakhoo

Authors
  1. Daniel C. Aronson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Graeme Pitcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. T. Joseph
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kokila Lakhoo
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Pediatric Surgery, Department of Surgery, National Hospital, Abuja, Nigeria

    Emmanuel A. Ameh

  2. Professor of Surgery & Pediatrics, Rady Children’s Hospital, University of California San Diego, San Diego, CA, USA

    Stephen W. Bickler

  3. Department of Pediatric Surgery, University of Oxford, Oxford, UK

    Kokila Lakhoo

  4. Department of Pediatric Surgery, Nationwide Children’s Hospital, and Department of Surgery, Ohio State University, Colombus, OH, USA

    Benedict C. Nwomeh

  5. Department of Pediatric Surgery, Montreal Children’s Hospital, Montreal, QC, Canada

    Dan Poenaru

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Aronson, D.C., Pitcher, G., Joseph, V.T., Lakhoo, K. (2020). Liver Tumours: The African Perspective. In: Ameh, E.A., Bickler, S.W., Lakhoo, K., Nwomeh, B.C., Poenaru, D. (eds) Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-41724-6_108

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-41724-6_108

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-41723-9

  • Online ISBN: 978-3-030-41724-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation