Skip to main content
SpringerLink
Log in

Microbial Polysaccharides as Cell/Drug Delivery Systems

  • Living reference work entry
  • First Online:
Polysaccharides of Microbial Origin

  • 30 Accesses

Abstract

Polysaccharides are considered to be excellent materials when compared with other polymers, due to their ease in tailoring, biocompatibility, bioactivity, homogeneity, bioadhesive nature, and ability to mimic the natural extracellular matrix microenvironment. Polysaccharides show great potentials for drug delivery and tissue engineering applications. The main aim of this chapter is to spotlight the new advancements and challenges concerned with microbial polysaccharides used for cell/drug delivery applications. In this chapter, the essential microbial polysaccharides including cellulose, Dextran, Pullulan, Xanthan, Salecan, Gellan, etc., which are sourced from plants, microbes, and animals, respectively, are reviewed. From the chapter it is concluded that the series of biocompatible microbial polysaccharides were promising candidates as smart drug delivery systems in future biomedical field.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Bai S, et al. Reduction stimuli-responsive unimolecular polymeric prodrug based on amphiphilic dextran-framework for antitumor drug delivery. Carbohydr Polym. 2018;182:235–44.

    Article  CAS  Google Scholar 

  • Chandra PK, Soker S, Atala A. Tissue engineering: current status and future perspectives. In: Principles of tissue engineering; 2020. https://doi.org/10.1016/B978-0-12-818422-6.00004-6.

    Chapter  Google Scholar 

  • Constantin M, Bucatariu S, Sacarescu L, Daraba OM, Anghelache M, Fundueanu G. Pullulan derivative with cationic and hydrophobic moieties as an appropriate macromolecule in the synthesis of nanoparticles for drug delivery. Int J Biol Macromol. 2020;164:4487–98.

    Article  CAS  Google Scholar 

  • Dang Y, Guan J. Nanoparticle-based drug delivery systems for cancer therapy. Smart Mater Med. 2020;1(February):10–9.

    Article  Google Scholar 

  • Dubey S, Mishra R, Roy P, Singh RP. 3-D macro/microporous-nanofibrous bacterial cellulose scaffolds seeded with BMP-2 preconditioned mesenchymal stem cells exhibit remarkable potential for bone tissue engineering. Int J Biol Macromol. 2021;167:934–46.

    Article  CAS  Google Scholar 

  • El Founi M, et al. Light-sensitive dextran-covered PNBA nanoparticles as triggered drug delivery systems: formulation, characteristics and cytotoxicity. J Colloid Interface Sci. 2018;514:289–98.

    Article  Google Scholar 

  • Ganbold T, Han S, Hasi A, Baigude H. Receptor-mediated delivery of therapeutic RNA by peptide functionalized curdlan nanoparticles. Int J Biol Macromol. 2019;126:633–40.

    Article  CAS  Google Scholar 

  • Giavasis I. Production of microbial polysaccharides for use in food. Woodhead Publishing; 2013. https://doi.org/10.1533/9780857093547.2.413.

    Book  Google Scholar 

  • Gopinath V, Saravanan S, Al-Maleki AR, Ramesh M, Vadivelu J. A review of natural polysaccharides for drug delivery applications: special focus on cellulose, starch and glycogen. Biomed Pharmacother. 2018;107:96–108.

    Article  CAS  Google Scholar 

  • Joshy KS, et al. Novel core-shell dextran hybrid nanosystem for anti-viral drug delivery. Mater Sci Eng C. 2018;93:864–72.

    Article  CAS  Google Scholar 

  • Karuppusamy S, Hyejin K, Kang HW. Nanoengineered chlorin e6 conjugated with hydrogel for photodynamic therapy on cancer. Colloids Surf B: Biointerfaces. 2019;181(May):778–88.

    Article  CAS  Google Scholar 

  • Lee MW, Tsai HF, Wen SM, Huang CH. Photocrosslinkable gellan gum film as an anti-adhesion barrier. Carbohydr Polym. 2012;90(2):1132–8.

    Article  CAS  Google Scholar 

  • Li L, Bai Z, Levkin PA. Boronate-dextran: an acid-responsive biodegradable polymer for drug delivery. Biomaterials. 2013;34(33):8504–10.

    Article  CAS  Google Scholar 

  • Li Z, Wang LN, Lin X, Shen L, Feng Y. Drug delivery for bioactive polysaccharides to improve their drug-like properties and curative efficacy. Drug Deliv. 2017;24(2):70–80.

    Article  CAS  Google Scholar 

  • Lian H, et al. Core cross-linked poly(ethylene glycol)-graft-dextran nanoparticles for reduction and pH dual responsive intracellular drug delivery. J Colloid Interface Sci. 2017;496:201–10.

    Article  CAS  Google Scholar 

  • Lin B, et al. Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes. Sci Bull. 2015;60(14):1272–80.

    Article  CAS  Google Scholar 

  • López-Cebral R, et al. Gellan gum based physical hydrogels incorporating highly valuable endogen molecules and associating BMP-2 as bone formation platforms. Carbohydr Polym. 2017;167:345–55.

    Article  Google Scholar 

  • Manivasagan P, Kim SK. Extracellular polysaccharides produced by marine bacteria. Adv Food Nutr Res. 2014;72:79–94.

    Article  CAS  Google Scholar 

  • Morris G, Harding S. Polysaccharides, microbial. Encycl Microbiol. 2009:482–94.

    Google Scholar 

  • Moscovici M. Present and future medical applications of microbial exopolysaccharides. Front Microbiol. 2015;6(SEP):1–11.

    Google Scholar 

  • Negahban Z, Shojaosadati SA, Hamedi S. A novel self-assembled micelles based on stearic acid modified schizophyllan for efficient delivery of paclitaxel. Colloids Surf B: Biointerfaces. 2021;199:111524.

    Article  CAS  Google Scholar 

  • Ngwabebhoh FA, Zandraa O, Patwa R, Saha N, Capáková Z, Saha P. Self-crosslinked chitosan/dialdehyde xanthan gum blended hypromellose hydrogel for the controlled delivery of ampicillin, minocycline and rifampicin. Int J Biol Macromol. 2021;167(December):1468–78.

    Article  CAS  Google Scholar 

  • Pacelli S, et al. Dextran-polyethylene glycol cryogels as spongy scaffolds for drug delivery. Int J Biol Macromol. 2021;166:1292–300.

    Article  CAS  Google Scholar 

  • Pandey S, et al. Natural gum modified emulsion gel as single carrier for the oral delivery of probiotic-drug combination. Int J Biol Macromol. 2016;92:504–14.

    Article  CAS  Google Scholar 

  • Pirzadeh-Naeeni S, Mozdianfard MR, Shojaosadati SA, Khorasani AC, Saleh T. A comparative study on schizophyllan and chitin nanoparticles for ellagic acid delivery in treating breast cancer. Int J Biol Macromol. 2020;144:380–8.

    Article  CAS  Google Scholar 

  • Psimadas D, Georgoulias P, Valotassiou V, Loudos G. Molecular nanomedicine towards cancer. J Pharm Sci. 2012;101(7):2271–80.

    Article  CAS  Google Scholar 

  • Qi X, et al. Design of Salecan-containing semi-IPN hydrogel for amoxicillin delivery. Mater Sci Eng C. 2017;75:487–94.

    Article  CAS  Google Scholar 

  • Qi X, et al. Sustainable, flexible and biocompatible hydrogels derived from microbial polysaccharides with tailorable structures for tissue engineering. Carbohydr Polym. 2020;237(March):116160.

    Article  CAS  Google Scholar 

  • Qin ZY, Jia XW, Liu Q, Kong BH, Wang H. Fast dissolving oral films for drug delivery prepared from chitosan/pullulan electrospinning nanofibers. Int J Biol Macromol. 2019;137:224–31.

    Article  CAS  Google Scholar 

  • Qiu L, et al. Elucidation of cellular uptake and intracellular trafficking of heparosan polysaccharide-based micelles in various cancer cells. Int J Biol Macromol. 2019;130:755–64.

    Article  CAS  Google Scholar 

  • Qu J, Liang Y, Shi M, Guo B, Gao Y, Yin Z. Biocompatible conductive hydrogels based on dextran and aniline trimer as electro-responsive drug delivery system for localized drug release. Int J Biol Macromol. 2019;140:255–64.

    Article  CAS  Google Scholar 

  • Ren L, Zhang J, Zhang T. Immunomodulatory activities of polysaccharides from Ganoderma on immune effector cells. Food Chem. 2021;340:127933.

    Article  CAS  Google Scholar 

  • Richa R, Choudhury AR. Exploration of polysaccharide based nanoemulsions for stabilization and entrapment of curcumin. Int J Biol Macromol. 2019;156:1287–96.

    Article  Google Scholar 

  • Shende P, Basarkar V. Recent trends and advances in microbe-based drug delivery systems. DARU J Pharm Sci. 2019;27(2):799–809.

    Article  Google Scholar 

  • Su T, Zhao W, Wu L, Dong W, Qi X. Facile fabrication of functional hydrogels consisting of pullulan and polydopamine fibers for drug delivery. Int J Biol Macromol. 2020;163:366–74.

    Article  CAS  Google Scholar 

  • Tiryaki E, BaÅŸaran Elalmış Y, Karakuzu Ä°kizler B, Yücel S. Novel organic/inorganic hybrid nanoparticles as enzyme-triggered drug delivery systems: dextran and dextran aldehyde coated silica aerogels. J Drug Deliv Sci Technol. 2020;56:101517.

    Google Scholar 

  • Unnikrishnan BS, et al. Self-assembled drug loaded glycosyl-protein metal nanoconstruct: detailed synthetic procedure and therapeutic effect in solid tumor treatment. Colloids Surf B: Biointerfaces. 2020;193(April):111082.

    Article  CAS  Google Scholar 

  • Vashisth P, et al. Drug functionalized microbial polysaccharide based nanofibers as transdermal substitute. Nanomed Nanotechnol Biol Med. 2016;12(5):1375–85.

    Article  CAS  Google Scholar 

  • Yao X, Chen L, Chen X, He C, Zheng H, Chen X. Intercellular pH-responsive histidine modified dextran-g-cholesterol micelle for anticancer drug delivery. Colloids Surf B: Biointerfaces. 2014;121:36–43.

    Article  CAS  Google Scholar 

  • Yunus Basha R, Sampath SK, Doble M. Dual delivery of tuberculosis drugs via cyclodextrin conjugated curdlan nanoparticles to infected macrophages. Carbohydr Polym. 2019;218(January):53–62.

    Article  CAS  Google Scholar 

  • Zhang R, et al. Polysaccharide from flammuliana velutipes improves colitis via regulation of colonic microbial dysbiosis and inflammatory responses. Int J Biol Macromol. 2020;149:1252–61.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Mechanical Engineering, KIT-Kalaignarkarunanidhi Institute of Technology, Coimbatore, Tamil Nadu, India

    M. Ramesh

  2. Department of Biotechnology, KIT-Kalaignarkarunanidhi Institute of Technology, Coimbatore, Tamil Nadu, India

    K. Sakthishobana & S. B. Suriya

Authors
  1. M. Ramesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Sakthishobana
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. B. Suriya
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. 3Bs Research Grp, Zona Indus da Gan, University of Minho, BARCO GMR, Portugal

    Joaquim Oliveira

  2. 3Bs Research Grp, Zona Indus da Gan, University of Minho, BARCO GMR, Portugal

    Hajer Radhouani

  3. 3Bs Research Grp, Zona Indus da Gan, University of Minho, BARCO GMR, Portugal

    Rui L. Reis

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Ramesh, M., Sakthishobana, K., Suriya, S.B. (2021). Microbial Polysaccharides as Cell/Drug Delivery Systems. In: Oliveira, J., Radhouani, H., Reis, R.L. (eds) Polysaccharides of Microbial Origin. Springer, Cham. https://doi.org/10.1007/978-3-030-35734-4_54-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-35734-4_54-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-35734-4

  • Online ISBN: 978-3-030-35734-4

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation