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Epidemiology of Frailty in Older People

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Frailty and Cardiovascular Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1216))

Abstract

Frailty is a complex of symptoms that is characterized by impaired stress tolerance due to a decline in the functionality of different organs. Due to its multifactorial aetiology, several definitions and assessments of this symptom complex have been developed, of which the Fried Frailty Score (Phenotype Score) and the broader Frailty Index (Deficit Accumulation Index) are the most commonly used. The prevalence of frailty increases with age independently of the assessment instrument and ranges between 4 and 59% in community-dwelling elderly populations and is higher in women than in men. The actual prevalence rate in a population depends on the prevalence of chronic diseases including depression, nutritional status, and inherently socio-economic background and education. Frailty is, however, not a steady state and progression, but also reversion is common. Although numerous studies on the prevalence of frailty have been conducted, systematic assessments in different populations are rare, which reduces the comparability of results. Similarly heterogeneous, but less frequent are studies on the incidence and on trajectories and transitions of frailty, calling for further, more systematic studies on this topic.

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References

  • Avila-Funes JA, Amieva H, Barberger-Gateau P, Le Goff M, Raoux N, Ritchie K et al (2009) Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study. J Am Geriatr Soc 57(3):453–461

    Article  Google Scholar 

  • Buta BJ, Walston JD, Godino JG, Park M, Kalyani RR, Xue QL et al (2016) Frailty assessment instruments: systematic characterization of the uses and contexts of highly-cited instruments. Ageing Res Rev. 26:53–61

    Article  Google Scholar 

  • Choi J, Ahn A, Kim S, Won CW (2015) Global prevalence of physical frailty by Fried’s criteria in community-dwelling elderly with national population-based surveys. J Am Med Dir Assoc 16(7):548–550

    Article  Google Scholar 

  • Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K (2013) Frailty in elderly people. Lancet 381(9868):752–762

    Article  Google Scholar 

  • Collard RM, Boter H, Schoevers RA, Oude Voshaar RC (2012) Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc 60(8):1487–1492

    Article  Google Scholar 

  • Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C et al (2012) Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85 + Study. Mech Ageing Dev 133(6):456–466

    Article  CAS  Google Scholar 

  • Etman A, Burdorf A, Van der Cammen TJ, Mackenbach JP, Van Lenthe FJ (2012) Socio-demographic determinants of worsening in frailty among community-dwelling older people in 11 European countries. J Epidemiol Commun Health 66(12):1116–1121

    Article  Google Scholar 

  • Feng Z, Lugtenberg M, Franse C, Fang X, Hu S, Jin C et al (2017) Risk factors and protective factors associated with incident or increase of frailty among community-dwelling older adults: a systematic review of longitudinal studies. PLoS ONE 12(6):e0178383

    Article  Google Scholar 

  • Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56(3):M146–M156

    Article  CAS  Google Scholar 

  • Galluzzo L, O’Caoimh R, Rodriguez-Laso A, Beltzer N, Ranhoff AH, Van der Heyden J et al (2018) Incidence of frailty: a systematic review of scientific literature from a public health perspective. Ann Ist Super Sanita 54(3):239–245

    PubMed  Google Scholar 

  • Hirsch C, Anderson ML, Newman A, Kop W, Jackson S, Gottdiener J et al (2006) The association of race with frailty: the cardiovascular health study. Ann Epidemiol 16(7):545–553

    Article  Google Scholar 

  • Hyde Z, Flicker L, Smith K, Atkinson D, Fenner S, Skeaf L et al (2016) Prevalence and incidence of frailty in Aboriginal Australians, and associations with mortality and disability. Maturitas 87:89–94

    Article  Google Scholar 

  • Jurschik P, Nunin C, Botigue T, Escobar MA, Lavedan A, Viladrosa M (2012) Prevalence of frailty and factors associated with frailty in the elderly population of Lleida, Spain: the FRALLE survey. Arch Gerontol Geriatr 55(3):625–631

    Article  Google Scholar 

  • Li G, Thabane L, Papaioannou A, Ioannidis G, Levine MA, Adachi JD (2017) An overview of osteoporosis and frailty in the elderly. BMC Musculoskelet Disord 18(1):46

    Article  Google Scholar 

  • Mitnitski AB, Graham JE, Mogilner AJ, Rockwood K (2002) Frailty, fitness and late-life mortality in relation to chronological and biological age. BMC Geriatr 2:1

    Article  Google Scholar 

  • Nguyen TN, Cumming RG, Hilmer SN (2015) A review of frailty in developing countries. J Nutr Health Aging. 19(9):941–946

    Article  CAS  Google Scholar 

  • O’Caoimh R, Galluzzo L, Rodriguez-Laso A, Van der Heyden J, Ranhoff AH, Carcaillon-Bentata L et al (2018) Transitions and trajectories in frailty states over time: a systematic review of the European Joint Action ADVANTAGE. Ann Ist Super Sanita 54(3):246–252

    PubMed  Google Scholar 

  • Ottenbacher KJ, Ostir GV, Peek MK, Snih SA, Raji MA, Markides KS (2005) Frailty in older Mexican Americans. J Am Geriatr Soc 53(9):1524–1531

    Article  Google Scholar 

  • Pena FG, Theou O, Wallace L, Brothers TD, Gill TM, Gahbauer EA et al (2014) Comparison of alternate scoring of variables on the performance of the frailty index. BMC Geriatr 14:25

    Article  Google Scholar 

  • Romero-Ortuno R (2013) The SHARE operationalized frailty phenotype: a comparison of two approaches. Eur Geriatr Med 4(4)

    Google Scholar 

  • Rothman MD, Leo-Summers L, Gill TM (2008) Prognostic significance of potential frailty criteria. J Am Geriatr Soc 56(12):2211–2216

    Article  Google Scholar 

  • Santos-Eggimann B, Cuenoud P, Spagnoli J, Junod J (2009) Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries. J Gerontol A Biol Sci Med Sci 64(6):675–681

    Article  Google Scholar 

  • Shivappa N, Stubbs B, Hebert JR, Cesari M, Schofield P, Soysal P et al (2018) The relationship between the dietary inflammatory index and incident frailty: a longitudinal cohort study. J Am Med Dir Assoc 19(1):77–82

    Article  Google Scholar 

  • Siriwardhana DD, Hardoon S, Rait G, Weerasinghe MC, Walters KR (2018) Prevalence of frailty and prefrailty among community-dwelling older adults in low-income and middle-income countries: a systematic review and meta-analysis. BMJ Open 8(3):e018195

    Article  Google Scholar 

  • Theou O, Brothers TD, Rockwood MR, Haardt D, Mitnitski A, Rockwood K (2013) Exploring the relationship between national economic indicators and relative fitness and frailty in middle-aged and older Europeans. Age Ageing 42(5):614–619

    Article  Google Scholar 

  • Trevisan C, Veronese N, Maggi S, Baggio G, De Rui M, Bolzetta F et al (2016) Marital status and frailty in older people: gender differences in the progetto veneto anziani longitudinal study. J Womens Health (Larchmt) 25(6):630–637

    Article  Google Scholar 

  • Verlaan S, Ligthart-Melis GC, Wijers SLJ, Cederholm T, Maier AB, de van der Schueren MAE (2017) High prevalence of physical frailty among community-dwelling malnourished older adults-A systematic review and meta-analysis. J Am Med Dir Assoc 18(5):374–382

    Google Scholar 

  • Wu C, Kim DH, Xue QL, Lee DSH, Varadhan R, Odden MC (2018) Association of frailty with recovery from disability among community-dwelling older adults: results from two large U.S. cohorts. J Gerontol A Biol Sci Med Sci 74(4):575–581

    Google Scholar 

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Correspondence to Sabine Rohrmann .

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Rohrmann, S. (2020). Epidemiology of Frailty in Older People. In: Veronese, N. (eds) Frailty and Cardiovascular Diseases . Advances in Experimental Medicine and Biology, vol 1216. Springer, Cham. https://doi.org/10.1007/978-3-030-33330-0_3

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