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Gastroesophageal Reflux and Sleep-Disordered Breathing

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Sleep Disordered Breathing in Children

Part of the book series: Respiratory Medicine ((RM))

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Abstract

Gastroesophageal reflux (GER) is a common clinical problem in children. Although GER can be physiological in infancy, a significant number of children will develop gastroesophageal reflux disease (GERD), as ­evidenced by the presence of accompanying esophageal and extra-­esophageal symptoms. There are profound physiological changes in the upper gastrointestinal tract function during sleep. In fact, sleep is viewed as a vulnerable state that promotes the presence of GER, and can therefore lead to GERD. Given the proximity of the upper airway to the upper gastrointestinal tract, sleep disordered breathing (SDB) and GERD share ­bi-directional cause and effect relationships. This chapter describes some of the pertinent mechanisms of GER, the changes in esophageal function that accompany sleep, and the clinical manifestations associated with sleep-related GERD.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, The University of Chicago, 5841 South Maryland Avenue, C104 E, MC 2117, Chicago, IL, 60637, USA

    Hari P. R. Bandla MD, MRCP(UK)

  2. Pulmonary Division, Phoenix Children’s Hospital, 1919 E Thomas Street, Phoenix, AZ, 85016, USA

    Aparna R. Rao MD

Authors
  1. Hari P. R. Bandla MD, MRCP(UK)
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  2. Aparna R. Rao MD
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Correspondence to Hari P. R. Bandla MD, MRCP(UK) .

Editor information

Editors and Affiliations

  1. Section of Sleep Medicine, Pritzker School of Medicine, Department of Pediatrics, S. Maryland Ave. 5721, Chicago, 60637, Illinois, USA

    Leila Kheirandish-Gozal

  2. Pritzker School of Medicine, Comer Children's Hospital, Department of Pediatrics, S. Maryland Ave. 5721, Chicago, 60637, Illinois, USA

    David Gozal

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Bandla, H.P.R., Rao, A.R. (2012). Gastroesophageal Reflux and Sleep-Disordered Breathing. In: Kheirandish-Gozal, L., Gozal, D. (eds) Sleep Disordered Breathing in Children. Respiratory Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-725-9_31

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  • DOI: https://doi.org/10.1007/978-1-60761-725-9_31

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-724-2

  • Online ISBN: 978-1-60761-725-9

  • eBook Packages: MedicineMedicine (R0)

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