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Functional Antibody Assays

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Vaccine Adjuvants

Part of the book series: Methods in Molecular Biology ((MIMB,volume 626))

Abstract

Functional antibody assays can broadly be divided into three categories: neutralisation, serum bactericidal antibody (SBA) and opsonophagocytic assays (OPA). These biological assays are generally more complex than antibody-binding counterparts. They invariably involve multiple biological components, many of which are difficult or impossible to standardise. The aim of this chapter is to provide working examples of these assays and highlight the key issues to be addressed to ensure they are able to provide reliable data.

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Authors and Affiliations

  1. National Institute for Biological Standards and Controls, Potters Bar, Hertfordshire, UK

    Ian Feavers & Barry Walker

Authors
  1. Ian Feavers
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  2. Barry Walker
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Corresponding author

Correspondence to Ian Feavers .

Editor information

Editors and Affiliations

  1. Dept. Cardio & Vascular Sciences, St. George's University of London, Cranmer Terrace, London, SW17 0RE, United Kingdom

    Gwyn Davies

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Feavers, I., Walker, B. (2010). Functional Antibody Assays. In: Davies, G. (eds) Vaccine Adjuvants. Methods in Molecular Biology, vol 626. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-585-9_14

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  • DOI: https://doi.org/10.1007/978-1-60761-585-9_14

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-584-2

  • Online ISBN: 978-1-60761-585-9

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