Summary
Searching online resources can provide medical researchers with an efficient means of gathering existing knowledge on the molecular causes of disease. The researcher may choose to explore the following areas, e.g., genetic mutations associated with the disease, function and cellular sub-localization of the associated protein(s) and their protein interaction partners. Using a small case study, examining the disease retinoblastoma, this chapter guides the reader through the relevant information contained within relevant databases. It is shown that the integration of online biological knowledge with genomic and proteomic experimental data provides insights into the understanding of diseases in their molecular context.
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Abbreviations
- GO:
-
gene ontology
- HPRD:
-
Human Protein Reference Database
- PTM:
-
post-translational modification
- RB1:
-
retinoblastoma
References
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© 2008 Humana Press, a part of Springer Science+Business Media, LLC
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Pang, C.N., Wilkins, M.R. (2008). Online Resources for the Molecular Contextualization of Disease. In: Trent, R.J. (eds) Clinical Bioinformatics. Methods in Molecular Medicine™, vol 141. Humana Press. https://doi.org/10.1007/978-1-60327-148-6_16
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DOI: https://doi.org/10.1007/978-1-60327-148-6_16
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