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Immobilized Enzymes for Biomedical Applications

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Immobilization of Enzymes and Cells

Part of the book series: Methods in Biotechnology™ ((MIBT,volume 22))

Abstract

Immobilized enzymes were first applied in the biomedical field aiming to detect bioactive substances or to treat a disease condition. This chapter presents two approaches used for the immobilization of L-asparaginase intended for the treatment of leukemia, based on the entrapment of this enzyme in a matrix. The particulate drug carriers described in this chapter are liposomes and nanoparticles, even though the methods described here could be used for the immobilization of other enzymes with therapeutic uses.

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Author information

Authors and Affiliations

  1. Laboratorio de Farmacia y Tecnologia Farmacéutica, Facultad de Farmacia, Universidad del Paés Vasco (EHU-UPV), Vitoria-Gasteiz, Spain

    Amaia Esquisabel

  2. Laboratorio de Farmacia y Tecnologia Farmacéutica, Facultad de Farmacia, Universidad del Paés Vasco (EHU-UPV), Vitoria-Gasteiz, Spain

    Rosa María Hernández

  3. Laboratorio de Farmacia y Tecnologia Farmacéutica, Facultad de Farmacia, Universidad del Paés Vasco (EHU-UPV), Vitoria-Gasteiz, Spain

    Alicia Rodríguez Gascón

  4. Laboratorio de Farmacia y Tecnologia Farmacéutica, Facultad de Farmacia, Universidad del Paés Vasco (EHU-UPV), Vitoria-Gasteiz, Spain

    José Luis Pedraz

Authors
  1. Amaia Esquisabel
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  2. Rosa María Hernández
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  3. Alicia Rodríguez Gascón
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  4. José Luis Pedraz
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Editor information

Editors and Affiliations

  1. Institute of Catalysis, CSIC, Campus UAM-Cantoblanco, Madrid, Spain

    Jose M. Guisan

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© 2006 Humana Press Inc.

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Esquisabel, A., Hernández, R.M., Gascón, A.R., Pedraz, J.L. (2006). Immobilized Enzymes for Biomedical Applications. In: Guisan, J.M. (eds) Immobilization of Enzymes and Cells. Methods in Biotechnology™, vol 22. Humana Press. https://doi.org/10.1007/978-1-59745-053-9_25

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  • DOI: https://doi.org/10.1007/978-1-59745-053-9_25

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-290-2

  • Online ISBN: 978-1-59745-053-9

  • eBook Packages: Springer Protocols

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