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The Regulation of Chromatin by Dynamic SUMO Modifications

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SUMO

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1475))

Abstract

Protein modification by the small ubiquitin-related modifier (SUMO) protein regulates numerous cellular pathways and mounting evidence reveals a critical role for SUMO in modulating gene expression. Dynamic sumoylation of transcription factors, chromatin-modifying enzymes, histones, and other chromatin-associated factors significantly affects the transcriptional status of the eukaryotic genome. Recent studies have employed high-throughput ChIP-Seq analyses to gain clues regarding the role of the SUMO pathway in regulating chromatin-based transactions. Indeed, the global distribution of SUMO across chromatin reveals an important function for SUMO in controlling transcription, particularly of genes involved in protein synthesis. These newly appreciated patterns of genome-wide sumoylation will inform more directed studies aimed at analyzing how the dynamics of gene expression are controlled by posttranslational SUMO modification.

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Acknowledgements

The authors would like to thank Jen Gillies and Jason Berk for their helpful comments on the manuscript. They also acknowledge support from the US National Institutes of Health (R01 GM053756) to M.H. and an NIH Ruth L. Kirschstein National Research Service Award (NRSA) predoctoral fellowship (F31 AG046965) to N.R.W.

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Authors and Affiliations

  1. Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT, 06520, USA

    Nicole R. Wilson & Mark Hochstrasser

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  1. Nicole R. Wilson
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  2. Mark Hochstrasser
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Correspondence to Mark Hochstrasser .

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Editors and Affiliations

  1. INBIOMED, San Sebastian, Spain

    Manuel S. Rodriguez

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Wilson, N.R., Hochstrasser, M. (2016). The Regulation of Chromatin by Dynamic SUMO Modifications. In: Rodriguez, M. (eds) SUMO. Methods in Molecular Biology, vol 1475. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6358-4_2

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  • DOI: https://doi.org/10.1007/978-1-4939-6358-4_2

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6356-0

  • Online ISBN: 978-1-4939-6358-4

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