Abstract
Atopic dermatitis (AD) is a chronic or chronically relapsing, pruritic inflammatory skin disease. The incidence of AD has dramatically increased for the past three decades in industrialized countries. We established a highly efficient method to induce AD-like skin lesions using repeated epicutaneous treatments with house dust mite allergen and staphylococcal enterotoxin B (SEB). The dermatitis-induced mice showed increased serum IgE levels that were similar to human AD patients and also treatable with dexamethasone. This mouse AD model has been used in a vaccinia virus infection study. It will also be useful to study pathogenic processes of AD and to evaluate the efficacy of a drug candidate. In this chapter, we describe the detailed method that can induce AD-like skin inflammation in multiple mouse strains.
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Kawakami, Y., Kawakami, T. (2015). A Mouse Model of Atopic Dermatitis. In: Hughes, M., McNagny, K. (eds) Mast Cells. Methods in Molecular Biology, vol 1220. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1568-2_30
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DOI: https://doi.org/10.1007/978-1-4939-1568-2_30
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