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Suppression of Demyelinating Diseases by Synthetic Copolymers

  • Chapter
A Multidisciplinary Approach to Myelin Diseases

Part of the book series: NATO ASI Series ((NSSA,volume 142))

Abstract

The experimental animal model for human demyelinating diseases used in our studies is experimental allergic encephalomyelitis (EAE). This is an acute neurological autoimmune disease, which can be induced in a variety of species, ranging from rodents to primates, by the injection of central nervous system (CNS) material in complete Freund’s adjuvant. The disease is associated with clinical manifestations, mainly paralysis of the hind legs, which culminate in death, and with the occurrence of histological lesions with perivascular infiltration in the brain. The clinical symptoms appear usually 2–3 weeks after challenge and are preceded by the histological damage (1,2).

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Authors and Affiliations

  1. Department of Chemical Immunology, Weizmann Institute of Science, Rehovoth, Israel

    R. Arnon & D. Teitelbaum

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  1. R. Arnon
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  2. D. Teitelbaum
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Editors and Affiliations

  1. Istituto Superiore di Sanità, Rome, Italy

    G. Serlupi Crescenzi

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© 1987 Plenum Press, New York

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Arnon, R., Teitelbaum, D. (1987). Suppression of Demyelinating Diseases by Synthetic Copolymers. In: Crescenzi, G.S. (eds) A Multidisciplinary Approach to Myelin Diseases. NATO ASI Series, vol 142. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0354-2_19

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  • DOI: https://doi.org/10.1007/978-1-4757-0354-2_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0356-6

  • Online ISBN: 978-1-4757-0354-2

  • eBook Packages: Springer Book Archive

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