Skip to main content
SpringerLink
Log in

Effects of Bradykinin, Eledoisin, and Physalaemin on Cardiovascular Dynamics

  • Chapter
Bradykinin and Related Kinins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 8))

Abstract

Recently, many investigators have studied the cardiovascular effects of the synthetic vasoactive peptides, bradykinin (2–6,12–15, 17, 20–22, 24, 27, 33, 40–44), eledoisin (3, 6, 10, 18, 23, 24, 26, 28–32, 40), and physalaemin (7, 19, 37). It has been well established that, with few exceptions (31, 46), the peptides exert directly a vasodilator action in many species of animals (1, 4–6, 11, 12, 25, 39, 41, 44, 46, 47). Consequently, the peptides appear to cause a variety of hemodynamic changes in the heart and circulation. The present studies were undertaken to investigate the precise effects of synthetic bradykinin, eledoisin and physalaemin on the cardiovascular dynamics and also to elucidate the underlying hemodynamic mechanisms responsible for the effects of these peptides in anesthetized dogs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Altura, B. M., Hershey, S. G., and Altura, B. T.: Pharmacol. Res. Comm. 1: 127, 1969.

    Article  Google Scholar 

  2. Antonio, A. and Rocha e Silva, M.: Circ. Res. 11: 910, 1962.

    PubMed  CAS  Google Scholar 

  3. Amorim, D. S., Mango, J. C., Ferreira, S. H., Sader, A. A. and Cardoso, S. S.: Int. Symp. on Vaso-active Polypeptides. Sao Paulo, Brazil, Aug. 1966, p. 5.

    Google Scholar 

  4. Bassenge, E., Werle, E., Holtz, J. and Fritz, H.: Pharmacol. Res. Comm. 1: 136, 1969.

    Article  Google Scholar 

  5. Bergamaschi, M. and Glasser, A. H.: Circ. Res. 13: 329, 1963.

    PubMed  CAS  Google Scholar 

  6. Bergamaschi, M. and Glasser, A. H.: Circ. Res. 15: 371, 1964.

    PubMed  CAS  Google Scholar 

  7. Bertaccini, G., Borghetti, A., De Caro, G. and La Greca, G. In “Hypotensive Peptides” (eds. Erdös, Back, and Sicuteri). Springer-Verlag, New York, 1966, p. 414.

    Chapter  Google Scholar 

  8. Bobbin, R. P. and Guth, P. S.: J. Pharmacol. Exp. Therap. 160: 91, 1968.

    Google Scholar 

  9. Boniface, K. J., Brodie, 0. J. and Walton R. P.: Proc. Soc. Exp. Biol. Med. 84: 263, 1953.

    PubMed  CAS  Google Scholar 

  10. Broghammer, H.: Klin. Wehr. 41: 1097, 1963.

    Article  CAS  Google Scholar 

  11. Burch, G. E. and De Pasquale, N. P.: Circ. Res. 10: 105, 1962.

    PubMed  CAS  Google Scholar 

  12. Chou, C. C., Frolich, E. D. and Texter, E. C., Jr.: J. Physiol. 176: 1, 1965.

    PubMed  CAS  Google Scholar 

  13. De Freitas, F. M., Faraco, E. Z. and De Azevedo, D.: Circ. 29: 66, 1964.

    Google Scholar 

  14. De Freitas, F. M., Faraco, E. Z., De Azevedo, D. and Lewin, I.: Circ. 29: 385, 1966.

    Google Scholar 

  15. Emerson, T. E.: Am. J. Physiol. 212: 1455, 1967.

    PubMed  CAS  Google Scholar 

  16. Feldberg, W. and Lewis, G. P.: J. Physiol. 171: 98, 1964.

    PubMed  CAS  Google Scholar 

  17. Feruglio, F. S., Greco, F., Cesano, L., Indovina, D., Sardi, G. and Chiandussi, L.: Clin. Sci. 26: 493, 1964.

    PubMed  CAS  Google Scholar 

  18. Gerola, A., Grazi, S. and Libreti, A.: Cardiol. 45: 261, 1964.

    Article  CAS  Google Scholar 

  19. Glasser, A. H. and Gregnan, G. B. In “Hypotensive Peptides” (eds. Erdös, Back, and Sicuteri). Springer-Verlag, New York, 1966, p. 407.

    Chapter  Google Scholar 

  20. Harrison, D. C., Henry, W. L., Paaso, B. and Miller, H. A.: Am. J. Physiol. 214: 1035, 1968.

    PubMed  CAS  Google Scholar 

  21. Hauge, A., Lunde, P. K. M. and Waaler, B. A.: Acta Physiol. Scand. 66: 269, 1966.

    Article  PubMed  CAS  Google Scholar 

  22. Kontos, H. A., Shapiro, W., Mauch, H. P. and Patterson, J. L.: Am. J. Physiol. 19: 113, 1964.

    CAS  Google Scholar 

  23. Kontos, H. A., Magee, J. H., Shapiro, W. and Patterson, J. L.: Circ. Res. 14: 351, 1964.

    PubMed  CAS  Google Scholar 

  24. Lockner, W. and Parratt, J. R.: Brit. J. Pharmacol. 26: 17, 1966.

    Google Scholar 

  25. Mason, D. T. and Melmon, K. L.: Circ. Res. 7: 106, 1965.

    Google Scholar 

  26. Maxwell, G. M.: Brit. J. Pharmacol. 22: 585, 1964.

    PubMed  CAS  Google Scholar 

  27. Maxwell, G. M., Eliott, R. B. and Kneebone, G. M.: Circ. Res. 10: 359, 1962.

    PubMed  CAS  Google Scholar 

  28. Nakano, J.: Federation Proc. 23: 436, 1964.

    Google Scholar 

  29. Nakano, J.: Life Sci. 3: 291, 1964.

    Article  PubMed  CAS  Google Scholar 

  30. Nakano, J.: J. Pharmacol. Exp. Therap. 145: 71, 1964.

    CAS  Google Scholar 

  31. Nakano, J.: Life Sci. 3: 937, 1964.

    Article  PubMed  CAS  Google Scholar 

  32. Nakano, J.: Proc. Soc. Exp. Biol. Med. 118: 108, 1965.

    PubMed  CAS  Google Scholar 

  33. Nakano, J.: Arch. Int. Pharmacodyn. 157: 1, 1965.

    PubMed  CAS  Google Scholar 

  34. Nakano, J.: Jap. Heart J. 7: 78, 1966.

    Article  PubMed  CAS  Google Scholar 

  35. Nakano, J.: Acta Cardiol. 23: 338, 1968.

    PubMed  CAS  Google Scholar 

  36. Nakano, J.: J. Pharmacol. Exp. Therap. 157: 19, 1967.

    CAS  Google Scholar 

  37. Nakano, J., Darrow, B. A. and McCurdy, J. R.: Arch. Int. Pharmacodyn. 112: 429, 1968.

    Google Scholar 

  38. Nakano, J. and Fisher, R. D.: J. Pharmacol. Exp. Therap. 142: 206, 1963.

    CAS  Google Scholar 

  39. Nakano, J. and Kusakari, T.: Angiology 17: 333, 1966.

    Article  PubMed  CAS  Google Scholar 

  40. Olmsted, F. and Page, I. H.: Am. J. Physiol. 203: 951, 1962.

    PubMed  CAS  Google Scholar 

  41. Paldino, R. L., Hyman, C. and Lenthall, C.: Circ. 11: 847, 1962.

    CAS  Google Scholar 

  42. Parratt, J. R.: Brit. J. Pharmacol. 22: 34, 1964.

    PubMed  CAS  Google Scholar 

  43. Rowe, G. G., Afonso, S., Castillo, C. A., Ling, F., Lugo, J. G. and Crumpton, C. W.: Am. Heart J. 65: 156, 1963.

    Google Scholar 

  44. Rowley, D. A.: Brit. J. Exp. Pathol. 45: 56, 1964.

    CAS  Google Scholar 

  45. Shipley, R. E. and Wilson, C.: Proc. Soc. Exp. Biol. Med. 78: 724, 1951.

    PubMed  CAS  Google Scholar 

  46. Stürmer, E. and Brodie, B.: J. Pharmacol. Exp. Therap. 140: 349, 1963.

    Google Scholar 

  47. Waaler, B. A.: J. Physiol. 157: 475, 1961.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pharmacology and of Medicine, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma, USA

    Jiro Nakano

Authors
  1. Jiro Nakano
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Clinical Pharmacology, University of Florence, Florence, Italy

    F. Sicuteri

  2. Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, U.S.P., Sao Paulo, Brazil

    M. Rocha e Silva

  3. Department of Biochemical Pharmacology School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

Rights and permissions

Reprints and permissions

Copyright information

© 1970 Plenum Press, New York

About this chapter

Cite this chapter

Nakano, J. (1970). Effects of Bradykinin, Eledoisin, and Physalaemin on Cardiovascular Dynamics. In: Sicuteri, F., e Silva, M.R., Back, N. (eds) Bradykinin and Related Kinins. Advances in Experimental Medicine and Biology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3198-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3198-8_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3200-8

  • Online ISBN: 978-1-4684-3198-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation