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Hematological Effects of Aging

Considerations for Clinical Trials

  • Chapter
Drug Studies in the Elderly

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Abstract

In 1951, a standard textbook of hematology reported the virtual absence of satisfactory information about the blood in old age.1 Although many studies of the effects of aging on peripheral blood cells and bone marrow have been carried out in the intervening years, a great deal of uncertainty and controversy about the nature of these effects remains. Well-designed gerontological studies are difficult to perform. Conclusions have frequently been drawn on the basis of data generated by studies in which methodology has been insufficient to distinguish between specific hematological effects of aging and effects of disease states that are prevalent in old age. This chapter will critically review the reported effects of aging on the structure and function of the peripheral blood and bone marrow, discuss the effects of drugs on the blood and bone marrow in old age, and present considerations for investigators who plan and carry out clinical trials in the elderly.

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Authors and Affiliations

  1. Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Elizabeth J. Read & Harvey G. Klein

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  1. Elizabeth J. Read
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  2. Harvey G. Klein
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Editors and Affiliations

  1. Department of Geriatrics Cedars-Sinai Medical Center, University of California-Los Angeles School of Medicine, 90048, Los Angeles, California, USA

    Neal R. Cutler M.D. (Director) (Director)

  2. Clinical Pharmacokinetics Research Laboratory Pharmacy Department Clinical Center, National Institutes of Health, 20892, Bethesda, Maryland, USA

    Prem K. Narang Ph.D. (Supervisor) (Supervisor)

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© 1986 Plenum Publishing Corporation

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Read, E.J., Klein, H.G. (1986). Hematological Effects of Aging. In: Cutler, N.R., Narang, P.K. (eds) Drug Studies in the Elderly. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1253-6_7

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  • DOI: https://doi.org/10.1007/978-1-4684-1253-6_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1255-0

  • Online ISBN: 978-1-4684-1253-6

  • eBook Packages: Springer Book Archive

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