Abstract
This article reviews research work being done in this laboratory.1–7
Although the central nervous system (CNS) is generally considered to be relatively resistant to direct effects of ionizing radiation, exposure to ionizing radiation can have a complex effect on the CNS that is dependent on the dose and time elapsed after radiation exposure.8 The biochemical basis for radiation-induced behavioral/physiological changes mediated by the CNS is unknown.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
S.B. Kandasamy, and W.A. Hunt, Arachidonic acid and prostaglandins enhance potassium-stimulated calcium influx into rat brain synaptosomes, Neuro-pharmacology 29:825 (1990).
S.B. Kandasamy, T.C. Howerton, and W.A. Hunt, Reductions in calcium uptake induced in rat brain synaptosomes by ionizing radiation, Radiat. Res.l25:158-162 (1991).
S.B. Kandasamy, and A.H. Harris, Effect of prostaglandins, inositol 1, 4, 5-trisphosphate, and phorbol esters on radiation-induced decreases in calcium influx in rat brain synaptosomes, Radial. Res. 131:43–46 (1992).
S.B. Kandasamy, S.A. Stevens-Blakely, T.K. Dalton, and A.H. Harris, Implication of nitric oxide synthase in radiation-induced decrease in hippocampal noradrenaline release in rats, in: The Biology of Nitric Oxide, S. Moncada, M.A. Marietta, J.B. Hibbs, Jr., and E. A. Higgs, eds., Portland Press, London (1992).
S.B. Kandasamy, Role of nitric oxide synthase, Superoxide dismutase, and glutathione peroxidase in radiation-induced decrease in norepinephrine release, in: The Neurobiology of NO and OH (C.C. Chiueh, D.L. Gilbert, and C.A. Colton, eds., Ann. N.Y. Acad. Sci., 738, New York, (1994).
H.T. Chen, G. Chen, S.B. Kandasamy, and A.H. Harris, Ionizing radiation decreases hippocampal protein kinase C (PKC) levels in rats, FASEB 7:A272 (1993).
S.B. Kandasamy, Effect of Bay K 8644, calcimycin and phorbol ester on radiation-induced decreases in the release of norepinephrine in the hippocampus in rats, Radial Res., 149:277–283 (1998).
D.J. Kimeldorf and E.L. Hunt, Neurophysiological effects of ionizing radiation, in: Ionizing Radiation: Neural Function and Behavior (D.J. Kimeldorf and E.L. Hunt, eds., Academic Press, New York (1965).
D.J. Heal, The effects of drugs on behavioural models of central noradrenergic function, in: The Pharmacology of Noradrenaline in the Central Nervous System (D.J. Heal, and C.A. Marsden, eds., Oxford University Press, New York, (1990).
G. Augustine, M.P. Charleton, and S.J. Smith, Calcium action in synaptic transmitter release, Annu. Rev. Neurosci. 10:633–693 (1987).
R.J. Miller, Multiple calcium channels and neuronal function. Science 235:46–47 (1987).
D.N. Midlemiss, The calcium channel activator, Bay K 8644, enhances K+-evoked efflux of acetylcholine and noradrenaline from rat brain slices. Naunyn-Schmiedebergs. Arch. Pharmacol. 331:114–116 (1985).
D.J. Dooley, A. Lupp, and G. Hertting, Inhibition of central neurotransmitter release by ω-conotoxin GVIA, a peptide modulator of the N-type voltage-sensitive calcium channel. Naunyn-Schmiedebergs, Arch. Pharmacol. 336:467–470 (1987).
Y. Nishizuka, Studies and perspectives of protein kinase C, Science (Wash. DC), 233: 305–312 (1986).
R.F. Akers, D.M. Lovinger, P.A. Colley, D.J. Linden, and A. Routenberg, Translocation of protein kinase C activity may mediate hippocampal long-term potentiation. Science 231:587–589 (1986).
U. Kikkawa, Y. Takai, R. Minakuchi, S. Inohara, and Y. Nishizuka, Calcium-activated, phospholipid-dependent protein kinase from rat brain, J. Biol. Chem. 257:13341–13348 (1982).
R.Z. Litten, E.A. Suba, and B.L. Roth, Effects of a phorbol ester on rat aortic concentration and calcium influx in the presence and absence of BAY K 8644, Eur. J. Pharmacol. 144:185–191 (1987).
H.Y. Huang, C. Allgaier, G. Hertting, and R. Jackisch, Phorbol ester-mediated enhancement of hippocampal noradrenaline release: Which ion channels are involved? Eur. J. Pharmacol. 153:175–184 (1988).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kandasamy, S.B. (1999). Gamma Radiation and Release of Norepinephrine in the Hippocampus. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_94
Download citation
DOI: https://doi.org/10.1007/978-1-4615-4793-8_94
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7171-7
Online ISBN: 978-1-4615-4793-8
eBook Packages: Springer Book Archive