Skip to main content
SpringerLink
Log in

Glucagon and Hypertriglyceridemia

  • Conference paper
GLUCAGON: Its Role in Physiology and Clinical Medicine

Abstract

The authors report the results of their studies on glucagon secretion in human endogenous hypertriglyceridemia and on its effects in hyperlipemic patients and in isolated rat liver.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Amatuzio, D. S., Grande, F., and Wada, S. (1962): Effect of glucagon on the serum lipids in essential hyperlipemia and hypercholesterolemia. Metabolism 11, 1240–1249.

    PubMed  CAS  Google Scholar 

  2. Aubry, F., Marcel, L. Y. and Davignon, J. (1974): Effects of glucagon on plasma lipids in different types of primary hyperlipoproteinemia. Metabolism 23, 225–238.

    Article  PubMed  CAS  Google Scholar 

  3. Bates, M., Linn, L. and Huen, A. (1976): Effects of oleic acid infusion on plasma free fatty acids and blood ketone bodies in the fasting rat. Metabolism 25, 361–374.

    Article  PubMed  CAS  Google Scholar 

  4. Bottger, I., Dobbs, R, Faloona, G. and Unger, R. H. (1973): The effects of triglyceride absorption upon glucagon, insulin and gut glucagon-like immunoreactivity. J. Clin. Invest. 52, 2532–2541.

    Article  PubMed  CAS  Google Scholar 

  5. Caren, R. and Corbo, L. (1974): Glucagon and plasma lipoprotein lipase. Proc. Soc. Exp. Biol. Med. 146, 1106–1110.

    PubMed  CAS  Google Scholar 

  6. Eaton, R. (1973): Hypolipemic action of glucagon in experimental endogenous lipemia in the rat. J. Lipid Res. 14. 312–318.

    PubMed  CAS  Google Scholar 

  7. Eaton, R. P. (1973): Glucagon secretion and activity in the cobalt chloride- treated rat. Am. J. Physiol. 225, 67–72.

    PubMed  CAS  Google Scholar 

  8. Eaton, R. (1973): Effect of clofibrate on arginine-induced insulin and glucagon secretion. Metabolism 22, 763–767.

    Article  PubMed  CAS  Google Scholar 

  9. Eaton, R. P., Oase, R. and Schade, D. S. (1976): Altered insulin and glucagon secretion in treated genetic hyperlipemia: a mechanism of therapy. Metabolism 25, 245–249.

    Article  PubMed  CAS  Google Scholar 

  10. Eaton, R. and Schade, D. (1973): Glucagon resistance as a hormonal basis for endogenous hyperlipemia. Lancet 1, 973–974.

    Article  PubMed  CAS  Google Scholar 

  11. Eaton, R. P. and Schade, D. S. (1974): Effect of clofibrate on arginine- stimulated glucagon and insulin secretion in man. Metabolism 23, 445–454.

    Article  PubMed  CAS  Google Scholar 

  12. Eaton, R. P., Schade, D. S. and Conway, M. (1974): Decreased glucagon activity: a mechanism for genetic and acquired endogenous hyperlipemia. Lancet 2, 1545–1547.

    Article  PubMed  CAS  Google Scholar 

  13. Fujita, Y., Gotto, A., Unger, R. H. (1974): Insulin (I), glucagon (G) and I/G ratio in carbohydrate (CHO)-induced hyperlipemia. Diabetes 23 (Suppl. 1), 372.

    Google Scholar 

  14. Gerich, J. E., Lorenzi, M., Bier, D. M., Schneider, V., Tsalikian, E., Karam, J. H. and Forsham, P. H. (1975): Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. New Engl. J. Med. 292, 985–989.

    Article  PubMed  CAS  Google Scholar 

  15. Gerich, J. E., Lorenzi, M., Bier, D. M., Tsalikian, E., Schneider, V., Karam, J. H. and Forsham, P. H. (1976): Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin. J. Clin. Invest. 57, 875–884.

    Article  PubMed  CAS  Google Scholar 

  16. Heimberg, M., Weinstein, I., Kohout, M. (1969): The effects of glucagon, dibutyryl cyclic adenosine 31,51 monophosphate, and concentration of free fatty acid on hepatic lipid metabolism. J. Biol. Chem. 244, 5131–5139.

    PubMed  CAS  Google Scholar 

  17. Liljenquist, J. E., Bomboy, J. D., Lewis, S. D., Sinclair-Smith, B. C., Felts, P. W., Lacy, W. W., Crofford, 0. B. and Liddle, G. W. (1974): Effects of glucagon on lipolysis and ketogenesis in normal and diabetic man. J. Clin. Invest. 53, 190–197.

    CAS  Google Scholar 

  18. Marks, V. (1976): Glucagon and lipid metabolism in man. Postgrad. Med. J. 49, 615 - 619.

    Google Scholar 

  19. McGarry, J. D. and Foster, D. W. (1974): The metabolism of (-)-octanoylcarnitine in perfused livers from fed and fasted rats. Evidence for a possible regulatory role of carnitine acyltransferase in the control of ketogenesis. J. Biol. Chem. 249, 7984–7996.

    PubMed  CAS  Google Scholar 

  20. McGarry, J. D., Wright, P. H. and Foster, D. W. (1975): Hormonal control of ketogenesis. Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon. J. Clin. Invest. 55, 1202–1209.

    Article  PubMed  CAS  Google Scholar 

  21. Muller, W. A., Faloona, G. R., Unger, R. H. and Aguilar-Parada, E. (1970): Abnormal alpha cell function in diabetes: response to carbohydrate and protein ingestion. New Engl. J. Med. 283, 109–115.

    Article  PubMed  CAS  Google Scholar 

  22. Nosadini, R., Solda, G., DeBiasi, F. and Tiengo, A.: Metabolic effects of glucagon in endogenous hypertriglyceridemia. Unpublished.

    Google Scholar 

  23. Paloyan, E. and Harper, P. U. (1961): Glucagon as a regulating factor of plasma lipids. Metabolism 10, 315–323.

    PubMed  CAS  Google Scholar 

  24. Salans, L. B., and Reaven, G. M. (1966): Effect of insulin pretreatment on glucose and lipid metabolism of liver slices from normal rats. Proc. Soc. Exp. Biol. Med. 122, 1208–1213.

    PubMed  CAS  Google Scholar 

  25. Schade, D. S. and Eaton, R. P. (1975): Modulation of fatty acid metabolism by glucagon in man. I. Effects of normal subjects. Diabetes 24, 502–509.

    Article  PubMed  CAS  Google Scholar 

  26. Schade, D. S. and Eaton, R. P. (1975): Modulation of fatty acid metabolism by glucagon in man. II. Effects in insulin-deficient diabetes. Diabetes 24, 510–515.

    Article  PubMed  CAS  Google Scholar 

  27. Schade, D. S. and Eaton, R. P. (1975): The contribution of endogenous insulin secretion to the ketogenic response to glucagon in man. Diabetologia 11, 555–559.

    Article  PubMed  CAS  Google Scholar 

  28. Schonfeld, G. and Pfleger, B. (1971): Utilization of exogenous free fatty acids for the production of very low density lipoprotein triglyceride by livers of carbohydrate-fed rats. J. Lipid. Res. 12, 614-621.

    Google Scholar 

  29. Sokal, J. (1966): Glucagon - an essential hormone. Amer. J. Med. 41, 331–341.

    Article  PubMed  CAS  Google Scholar 

  30. Tiengo, A.,Fedele, D., Muggeo, M. and Crepaldi, G. (1973): Diabetic-like behaviour of glucagon secretion in primary endogenous hypertriglyceridemia. 8th Congr. Intern. Diabetes Feder., Brussels. Excerpta Med. ICS 280, 47.

    Google Scholar 

  31. Tiengo, A., Muggeo, M., Assan, R., Fedele, D. and Crepaldi, G. (1975): Glucagon secretion in primary endogenous hypertriglyceridemia before and after clofibrate treatment. Metabolism 24, 901–914.

    Article  PubMed  CAS  Google Scholar 

  32. Tiengo, A., Muggeo, M., Fedele, D., Nosadini, R. and Crepaldi, G. (1975): La sScr§tion d1insuline et de glucagon dans 1’hypertriglyceridemia endogene. In: Journees Annuelles de Diabetologie de l’Hotel-Dieu. Flammarion, Paris.

    Google Scholar 

  33. Topping, D. L. and Mayes, P. A. (1971): The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipo-protein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism. Biochem. J. 126, 295–311.

    Google Scholar 

  34. Unger, R. H. (1971): Glucagon and the insulin:glucagon ratio in diabetes and other catabolic illnesses. Diabetes 20., 834–838.

    Google Scholar 

  35. Unger, R. H. (1972): Pancreatic alpha-cell function in diabetes mellitus. In: Glucagon, Molecular Physiology, Clinical and Therapeutic Implications. P. J. Lefebvre and R. H. Unger, Eds. Pergamon Press, Oxford, pp. 245–257.

    Google Scholar 

  36. Unger, R. H., Madison, L. L. and Muller, W. A. (1972): Abnormal alpha cell function in diabetes. Response to insulin. Diabetes 21, 301–307.

    Google Scholar 

  37. Weinstein, I., Klausner, H. A. and Heimberg, M. (1973): The effect of concentration of glucagon on output of triglyceride, ketone bodies, glucose, and urea by the liver. Biochim. Biophys. Acta 296, 300–309.

    PubMed  CAS  Google Scholar 

  38. Williamson, J. R., Browning, E. T., Thurman, R. G. and Scholz, R. (1969): Inhibition of glucagon effects in perfused rat liver by (+)decanoylcarni- tine. J. Biol. Chem. 244, 5055–5064.

    PubMed  CAS  Google Scholar 

  39. Wise, J. K., Hendler, R. and Felig, P. (1973): Evaluation of alpha-cell function by infusion of alanine in normal, diabetic and obese subjects. New Engl. J. Med. 288, 487–490.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Gerontology and Metabolic Diseases, University of Padova, Padova, Italy

    A. Tiengo, R. Nosadini, M. C. Garotti, D. Fedele, M. Muggeo & G. Crepaldi

  2. Department of Internal Medicine, University of Padova, Padova, Italy

    A. Tiengo, R. Nosadini, M. C. Garotti, D. Fedele, M. Muggeo & G. Crepaldi

Authors
  1. A. Tiengo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Nosadini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. C. Garotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. Fedele
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Muggeo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. Crepaldi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology, Wayne State University School of Medicine, 48201, Detroit, Michigan, USA

    Piero P. Foà

  2. Department of Medicine, All-India Institute of Medical Sciences, 110016, New Delhi, India

    Jasbir S. Bajaj

  3. Department of Research, Sinai Hospital of Detroit, 48235, Detroit, Michigan, USA

    Naomi L. Foà

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Springer-Verlag New York Inc.

About this paper

Cite this paper

Tiengo, A., Nosadini, R., Garotti, M.C., Fedele, D., Muggeo, M., Crepaldi, G. (1977). Glucagon and Hypertriglyceridemia. In: Foà, P.P., Bajaj, J.S., Foà, N.L. (eds) GLUCAGON: Its Role in Physiology and Clinical Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6366-1_49

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-6366-1_49

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6368-5

  • Online ISBN: 978-1-4612-6366-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation