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Molecular and Cellular Aspects of Embryonal Carcinoma Cell Differentiation

  • Chapter
Tumor Cell Differentiation

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 17))

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Abstract

Embryonal carcinoma cells represent a subpopulation of undifferentiated stem cells contained within a mixture of differentiated cell phenotypes of teratocarcinoma tumors (1). Such tumors can develop spontaneously in gonadal tissue of certain mouse strains (2,3) and can be induced experimentally (4,5). The undifferentiated EC cells are the primary malignant cells of the tumor and are similar to early embryonic ectoderm morphologically (6), biochemically (7) and antigenically (8). Like early ectoderm cells, EC cells are pluripotent since injection of EC cells into host blastocysts leads to formation of chimeric mice (9–11).

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Author information

Authors and Affiliations

  1. Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267, USA

    Joel Schindler

Authors
  1. Joel Schindler
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Institute of Medical Biology, University of Tromsö, Tromsö, Norway

    Jarle Aarbakke

  2. Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, DC, USA

    Peter K. Chiang

  3. University of California, Los Angeles, California, USA

    H. Phillip Koeffler

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© 1987 The Humana Press Inc.

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Schindler, J. (1987). Molecular and Cellular Aspects of Embryonal Carcinoma Cell Differentiation. In: Aarbakke, J., Chiang, P.K., Koeffler, H.P. (eds) Tumor Cell Differentiation. Experimental Biology and Medicine, vol 17. Humana Press. https://doi.org/10.1007/978-1-4612-4594-0_9

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  • DOI: https://doi.org/10.1007/978-1-4612-4594-0_9

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8941-8

  • Online ISBN: 978-1-4612-4594-0

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