Abstract
The acute crush injuries of peripheral nerves are seen frequently after various traumas. The resulting morbidity depends on combined effect of mechanical pressure and ischemic injury, timing and extent of injury. The sensorial and functional deficits range from paresthesias to complete sensory loss and from partial motor weakness to complete nerve paralysis. The rat sciatic nerve crush injury model is the most commonly used experimental model for understanding the crush injury mechanism, treatment modalities and recovery of the nerve. In this chapter, we briefly present a standardized crush injury model and methods of nerve recovery evaluation after peripheral nerve crush injury.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Algora J, Chen L, Seaber AV, Wong GHW, Urbaniak JR. Functional effects of lymphotoxin on crushed peripheral nerve. Microsurgery. 1996;17:131–5.
Bain JR, Mackinnon SE, Hunter DA. Functional evaluation of complete sciatic, peroneal and posterior tibial nerve lesions in the rat. Plast Reconstr Surg. 1989;83:129–38.
Bridge PM, Ball DJ, Mackinnon SE, Nakao Y, Brandt K, Hunter DA, et al. Nerve crush injuries: a model for axonotmesis. Exp Neurol. 1994;127:284–90.
Chen LE, Seaber AV, Glisson RR, Davies H, Murrell GA, Anthony DC, et al. The functional recovery of peripheral nerves following defined acute crush injuries. J Orthop Res. 1992;10:657–64.
De Koning P, Brakkee JH, Gispen WH. Methods for producing a reproducible crush in the sciatic and tibial nerve of the rat and rapid and precise testing of return of sensory function. Beneficial effects of melanocortins. J Neurol Sci. 1986;74:237–46.
Dinh P, Hazel A, Palispis W, Suryadevara S, Gupta R. Functional assessment after sciatic nerve injury in a rat model. Microsurgery. 2009;29:644–9.
Gudemez E, Ozer K, Cunningham B, Siemionow K, Browne E, Siemionow M. Dehydroepiandrosterone as an enhancer of functional recovery following crush injury to rat sciatic nerve. Microsurgery. 2002;22:234–41.
Hadlock TA, Koka R, Vacanti JP, Cheney ML. A comparison of assessments of functional recovery in the rat. J Peripher Nerv Syst. 1999;4:258–64.
Kingery WS, Lu JD, Roffers JA, Kell DR. The resolution of neuropathic hyperalgesia following motor and sensory functional recovery in sciatic axonotmetic mononeuropathies. Pain. 1994;58:157–68.
Koka R, Hadlock TA. Quantification of functional recovery following rat sciatic nerve transection. Exp Neurol. 2001;168:192–5.
Li Y, Bickel KD, Im MJ, Hu L, Dellon AL, Vander Kolk CA, et al. Effects of deferoxamine on ischemia/reperfusion injury after peripheral nerve compression. Ann Plast Surg. 1996;36:365–9.
Lundborg G, Dahlin LB. Anatomy, function, and pathophysiology of peripheral nerves and nerve compression. Hand Clin. 1996;2:185–93.
Mackinnon SE, Dellon AL, Hunter DA. Histologic assessment of nerve regeneration in the rat. Plast Reconstr Surg. 1985;75:384–8.
Mackinnon SE, Dellon AL, Hudson AR, Hunter DA. Chronic nerve compression: an experimental model in the rat. Ann Plast Surg. 1984;13:112–20.
Mazzer PY, Barbieri CH, Mazzer N, Fazan VP. Morphologic and morphometric evaluation of experimental acute crush injuries of the sciatic nerve of rats. J Neurosci Methods. 2008;173(2):249–58.
Navarro X, Kennedy WR. Sweat gland reinnervation by sudomotor regeneration after different types of lesions and graft repairs. Exp Neurol. 1989;104:229–34.
Oliveira EF, Mazzer N, Barbieri CH, Selli M. Correlation between functional index and morphometry to evaluate recovery of the rat sciatic nerve following crush injury: experimental study. J Reconstr Microsurg. 2001;17:69–75.
Ronchi G, Nicolino S, Raimondo S, Tos P, Battiston B, Papalia I, et al. Functional and morphological assessment of a standardized crush injury of the rat median nerve. J Neurosci Methods. 2009;179:51–7.
Sarikcioglu L, Yaba A, Tanriover G, Demirtop A, Demir N, Ozkan O. Effect of severe crush injury on axonal regeneration: a functional and ultrastructural study. J Reconstr Microsurg. 2007;23:143–9.
Schmelzer JD, Zochodne DW, Low PA. Ischemic and reperfusion injury of rat peripheral nerve. Proc Natl Acad Sci U S A. 1989;86:1639–42.
Siemionow M, Demir Y, Mukherjee AL. Repair of peripheral nerve defects with epineural sheath grafts. Ann Plast Surg. 2010;65:546–54.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag London
About this chapter
Cite this chapter
Ozturk, C. (2015). Peripheral Nerve Surgery Models Sciatic Nerve Crush Injury Model. In: Siemionow, M. (eds) Plastic and Reconstructive Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-6335-0_63
Download citation
DOI: https://doi.org/10.1007/978-1-4471-6335-0_63
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-6334-3
Online ISBN: 978-1-4471-6335-0
eBook Packages: MedicineMedicine (R0)