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Analysis of Resting-State Functional Magnetic Resonance Imaging in Alzheimer’s Disease

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Biomarkers for Alzheimer’s Disease Drug Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2785))

Abstract

Alzheimer’s disease (AD) has been characterized by widespread network disconnection among brain regions, widely overlapping with the hallmarks of the disease. Functional connectivity has been studied with an upward trend in the last two decades, predominantly in AD among other neuropsychiatric disorders, and presents a potential biomarker with various features that might provide unique contributions to foster our understanding of neural mechanisms of AD. The resting-state functional MRI (rs-fMRI) is usually used to measure the blood-oxygen-level-dependent signals that reflect the brain’s functional connectivity. Nevertheless, the rs-fMRI is still underutilized, which might be due to the fairly complex acquisition and analytic methodology. In this chapter, we presented the common methods that have been applied in rs-fMRI literature, focusing on the studies on individuals in the continuum of AD. The key methodological aspects will be addressed that comprise acquiring, processing, and interpreting rs-fMRI data. More, we discussed the current and potential implications of rs-fMRI in AD.

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany

    Ersin Ersözlü & Boris-Stephan Rauchmann

  2. Department of Geriatric Psychiatry and Developmental Disorders, kbo-Isar-Amper-Klinikum Munich East, Academic Teaching Hospital of LMU Munich, Munich, Germany

    Ersin Ersözlü

  3. Department of Neuroradiology, University Hospital, LMU Munich, Munich, Germany

    Boris-Stephan Rauchmann

  4. German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

    Boris-Stephan Rauchmann

  5. Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK

    Boris-Stephan Rauchmann

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  1. Ersin Ersözlü
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  2. Boris-Stephan Rauchmann
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  1. Department of Psychiatry and Psychotherapy, LMU Klinikum, München, Germany

    Robert Perneczky

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Ersözlü, E., Rauchmann, BS. (2024). Analysis of Resting-State Functional Magnetic Resonance Imaging in Alzheimer’s Disease. In: Perneczky, R. (eds) Biomarkers for Alzheimer’s Disease Drug Development. Methods in Molecular Biology, vol 2785. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3774-6_7

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  • DOI: https://doi.org/10.1007/978-1-0716-3774-6_7

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