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New Perspectives on Crosstalks Between Bacterial Regulatory RNAs from Outer Membrane Vesicles and Eukaryotic Cells

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Bacterial Regulatory RNA

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2741))

Abstract

Regulatory small RNAs (sRNAs) help the bacteria to survive harsh environmental conditions by posttranscriptional regulation of genes involved in various biological pathways including stress responses, homeostasis, and virulence. These sRNAs can be found carried by different membrane-bound vesicles like extracellular vesicles (EVs), membrane vesicles (MVs), or outer membrane vesicles (OMVs). OMVs provide myriad functions in bacterial cells including carrying a cargo of proteins, lipids, and nucleic acids including sRNAs. A few interesting studies have shown that these sRNAs can be transported to the host cell by membrane vesicles and can regulate the host immune system. Although there is evidence that sRNAs can be exported to host cells and sometimes can even cross the blood–brain barrier, the exact mechanism is still unknown. In this review, we investigated the new techniques implemented in various studies, to elucidate the crosstalks between bacterial cells and human immune systems by membrane vesicles carrying bacterial regulatory sRNAs.

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Authors and Affiliations

  1. Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, Québec, Canada

    Moumita Roy Chowdhury

  2. Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, Québec, Canada

    Eric Massé

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  1. Moumita Roy Chowdhury
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  2. Eric Massé
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Correspondence to Eric Massé .

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Editors and Affiliations

  1. CEA Saclay, Lab Léon Brillouin UMR12 CEA/CNRS, Gif-sur-Yvette, France

    Véronique Arluison

  2. Laboratorio de Fisiología y Genética de Bacterias Beneficiosas para Plantas (LFGBBP), Centro de Bioquímica y Microbiología del Suelo (CBMS), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes – CONICET, Bernal, Buenos Aires, Argentina

    Claudio Valverde

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Roy Chowdhury, M., Massé, E. (2024). New Perspectives on Crosstalks Between Bacterial Regulatory RNAs from Outer Membrane Vesicles and Eukaryotic Cells. In: Arluison, V., Valverde, C. (eds) Bacterial Regulatory RNA. Methods in Molecular Biology, vol 2741. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3565-0_10

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  • DOI: https://doi.org/10.1007/978-1-0716-3565-0_10

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3564-3

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