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Bacteriophage–Host Interactions and Coevolution

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Bacteriophages

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2738))

Abstract

Bacteriophages are the most abundant entity on the planet and play very relevant roles in the diversity and abundance of their bacterial hosts. These interactions are subject to several factors, such as the first encounter of the phage with its host bacterium, in which molecular interactions are fundamental. Along with this, these interactions depend on the environment and other communities present. This chapter focuses on these phage–bacteria interactions, reviewing the knowledge of the early stage (receptor-binding proteins), host responses (resistance and counter-resistance), and ecological and evolutionary models described to date. In general, knowledge has focused on a few phage–bacteria models and has been deepened by sequencing and metagenomics. The study of phage–bacteria interactions is an essential step for the development of therapies and other applications of phages in the clinical and productive environment.

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Acknowledgments

This work was supported by the “Agencia Nacional de Investigación y Desarrollo ANID” Chile grants: FONDECYT 1181167 and 1231082 supported AIMS, FONDECYT 3210317 supported DAE, and ANID FONDEF VIU22P0058 supported DR.

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Authors and Affiliations

  1. Escuela de Medicina Veterinaria, Pontificia Universidad Católica de Chile, Santiago, Chile

    Diana M. Álvarez-Espejo & Andrea I. Moreno-Switt

  2. Escuela de Medicina Veterinaria, Universidad Andres Bello, Santiago, Chile

    Dácil Rivera

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  1. Diana M. Álvarez-Espejo
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  2. Dácil Rivera
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  3. Andrea I. Moreno-Switt
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Correspondence to Andrea I. Moreno-Switt .

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  1. School of Veterinary Medicine, Texas Tech University, Amarillo, TX, USA

    Ebenezer Tumban

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Álvarez-Espejo, D.M., Rivera, D., Moreno-Switt, A.I. (2024). Bacteriophage–Host Interactions and Coevolution. In: Tumban, E. (eds) Bacteriophages. Methods in Molecular Biology, vol 2738. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3549-0_15

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