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Neuroimaging Human Dopamine-Related Neurophysiology Across Development

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Dopaminergic System Function and Dysfunction: Experimental Approaches

Part of the book series: Neuromethods ((NM,volume 193))

Abstract

Measures of dopamine (DA) in vivo in humans have been obtained using positron emission tomography (PET), however, its invasive nature and exposure to radioactivity has limited its application to populations such as pediatric cohorts. Brain tissue iron measured noninvasively with magnetic resonance imaging (MRI) has been found to be linked to DA neurophysiology in the basal ganglia, providing a novel approach for in vivo human characterization of DA function. This chapter describes the links between brain tissue iron and DA neurophysiology, the MRI approaches available to measure it, and application to understanding development and disease. The literature characterizing brain tissue iron in DA neurophysiology and new advances in MRI approaches to measure it support this as an innovative and promising approach to understand the DAergic mechanisms underlying lifespan development and disease.

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Authors and Affiliations

  1. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA

    Ashley Parr & Beatriz Luna

  2. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Bart Larsen

  3. Department of Psychiatry and Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA

    Finnegan Calabro

  4. Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Brenden Tervo-Clemmens

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  1. Ashley Parr
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  1. Escuela de Química y Farmacia y Centro Interdisciplinario de Neurociencia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile

    José Antonio Fuentealba-Evans

  2. Departamento de Anatomía Normal, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

    Pablo Henny

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Parr, A., Larsen, B., Calabro, F., Tervo-Clemmens, B., Luna, B. (2023). Neuroimaging Human Dopamine-Related Neurophysiology Across Development. In: Fuentealba-Evans, J.A., Henny, P. (eds) Dopaminergic System Function and Dysfunction: Experimental Approaches. Neuromethods, vol 193. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2799-0_13

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