Skip to main content
SpringerLink
Log in

Combination of Photodynamic Therapy and Immune Checkpoint Blockade

  • Protocol
  • First Online:
Photodynamic Therapy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2451))

  • 1056 Accesses

Abstract

Photodynamic therapy (PDT) for cancer not only strongly reduces tumor mass but can also induce or enhance immune responses against the tumor by causing the release of tumor antigen and danger signals from dying tumor cells. This supports combinations of PDT and immunotherapy for the treatment of advanced tumors for which single therapies are insufficiently effective. Immune checkpoint blockade is a prominent type of cancer immunotherapy that aims to restore the effector function of immune cells, most often T cells, by administering antibodies that block inhibitory molecules. In this chapter, we describe the combination of PDT with immune checkpoint blockade in a mouse tumor model.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Pauken KE, Wherry EJ (2015) Overcoming T cell exhaustion in infection and cancer. Trends Immunol 36:265–276. https://doi.org/10.1016/j.it.2015.02.008

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Zarour HM (2016) Reversing T-cell dysfunction and exhaustion in cancer. Clin Cancer Res 22:1856–1864. https://doi.org/10.1158/1078-0432.CCR-15-1849

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Pardoll DM (2012) The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12:252–264. https://doi.org/10.1038/nrc3239

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Postow MA, Callahan MK, Wolchok JD (2015) Immune checkpoint blockade in cancer therapy. J Clin Oncol 33:1974–1982. https://doi.org/10.1200/JCO.2014.59.4358

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Castano AP, Mroz P, Hamblin MR (2006) Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer 6:535–545

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Mroz P, Hashmi JT, Huang Y-Y et al (2011) Stimulation of anti-tumor immunity by photodynamic therapy. Expert Rev Clin Immunol 7:75–91. https://doi.org/10.1586/eci.10.81

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Kleinovink JW, Fransen MF, Löwik CW, Ossendorp F (2017) Photodynamic-immune checkpoint therapy eradicates local and distant tumors by CD8+T cells. Cancer Immunol Res 5. https://doi.org/10.1158/2326-6066.CIR-17-0055

Download references

Author information

Authors and Affiliations

  1. Department of Immunology, Tumor Immunology group, Leiden University Medical Center, Leiden, The Netherlands

    Jan Willem Kleinovink & Ferry Ossendorp

Authors
  1. Jan Willem Kleinovink
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ferry Ossendorp
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ferry Ossendorp .

Editor information

Editors and Affiliations

  1. Institute for Advanced Biosciences, Université de Grenoble Alpes, Grenoble, France

    Mans Broekgaarden

  2. van ‘t Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands

    Hong Zhang

  3. British Columbia Cancer Research Centre, Vancouver, BC, Canada

    Mladen Korbelik

  4. Laser Research Centre, University of Johannesburg, Doornfontein, South Africa

    Michael R. Hamblin

  5. Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, Jiaxing University College of Medicine, Jiaxing, Zhejiang, China

    Michal Heger

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Science+Business Media, LLC, part of Springer Nature

About this protocol

Check for updates. Verify currency and authenticity via CrossMark

Cite this protocol

Kleinovink, J.W., Ossendorp, F. (2022). Combination of Photodynamic Therapy and Immune Checkpoint Blockade. In: Broekgaarden, M., Zhang, H., Korbelik, M., Hamblin, M.R., Heger, M. (eds) Photodynamic Therapy. Methods in Molecular Biology, vol 2451. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2099-1_30

Download citation

  • DOI: https://doi.org/10.1007/978-1-0716-2099-1_30

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2098-4

  • Online ISBN: 978-1-0716-2099-1

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics

Search

Navigation