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From Cerebellar Genes to Behaviors in Zebrafish

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Measuring Cerebellar Function

Part of the book series: Neuromethods ((NM,volume 177))

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Abstract

The cerebellum is involved in some forms of motor coordination and learning, and also in non-motor cognitive and emotional functions. These functions of the cerebellum rely on the structure of the neural circuit which is generally conserved among vertebrates. As the zebrafish became a versatile animal model to study the development and function of the vertebrate brain, its cerebellum was studied over the last decade. Although the zebrafish cerebellum has a small and simple structure, it has layer and neural circuit structures as well as motor and non-motor functions similar to the mammalian cerebellum, and the same genetic program. Therefore, the zebrafish cerebellum is a good model for understanding the development and function of the cerebellum of mammals, including humans. In this review, we outline the structure and development of the zebrafish cerebellum, and explain the molecular and transgenic tools that are used to study it. Finally, we discuss how studies on the zebrafish cerebellar circuits contribute to our understanding the vertebrate cerebellum and human diseases caused by cerebellar defects.

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Notes

  1. 1.

    The role of the zebrafish cerebellum in active avoidance has recently been reported in [100].

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Acknowledgements

The authors thank past and current members of the Hibi Laboratory for their contribution to the works cited here.

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Authors and Affiliations

  1. Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Aichi, Japan

    Masahiko Hibi & Takashi Shimizu

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  1. Masahiko Hibi
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  2. Takashi Shimizu
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Correspondence to Masahiko Hibi .

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  1. Houston, TX, USA

    Roy V. Sillitoe

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Hibi, M., Shimizu, T. (2022). From Cerebellar Genes to Behaviors in Zebrafish. In: Sillitoe, R.V. (eds) Measuring Cerebellar Function. Neuromethods, vol 177. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2026-7_2

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  • DOI: https://doi.org/10.1007/978-1-0716-2026-7_2

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  • Publisher Name: Humana, New York, NY

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