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Recent Advances and Future Directions: Clinical Applications of Intraoperative BOLD-MRI CVR

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Cerebrovascular Reactivity

Part of the book series: Neuromethods ((NM,volume 175))

Abstract

Blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) sequences have gained widespread interest in recent years as an effective way to investigate cerebrovascular reactivity (CVR, a measure of the hemodynamic state of the brain) with a high spatial and temporal resolution. The clinical relevance of CVR in diverse pathologies has been widely tested, especially ischemic cerebrovascular diseases. Here, its importance has been confirmed both preoperatively for a better stratification risk and postoperatively to evaluate the effectiveness of revascularization procedures. Recently, CVR assessments have shown interesting findings in neuro-oncology. The ability to obtain this information intraoperatively is, however, novel and has not been tested. We report our first experience with this intraoperative technique in vascular and oncologic neurosurgical patients and discuss the results of its feasibility and the possible developments of the intraoperative employment of BOLD-CVR.

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Change history

  • 29 January 2022

    The authors name Alessandro Della Puppa is wrongly listed as “Puppa A.D” and this has been updated.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Careggi University Hospital, University of Florence, Florence, Italy

    Giovanni Muscas & Alessandro Della Puppa

  2. Department of Neurosurgery, Zurich University Hospital, University of Zurich, Zurich, Switzerland

    Christiaan Hendrik Bas van Niftrik, Martina Sebök & Luca Regli

  3. Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland

    Giovanni Muscas & Jorn Fierstra

  4. Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland

    Giovanni Muscas & Jorn Fierstra

Authors
  1. Giovanni Muscas
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  2. Christiaan Hendrik Bas van Niftrik
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  3. Martina Sebök
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  4. Alessandro Della Puppa
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  5. Luca Regli
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  6. Jorn Fierstra
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Corresponding author

Correspondence to Giovanni Muscas .

Editor information

Editors and Affiliations

  1. Baycrest Centre for Geriatric Care, University of Toronto, Toronto, ON, Canada

    Jean Chen

  2. Department of Neurosurgery, University Hospital Zurich, ZĂĽrich, ZĂĽrich, Switzerland

    Jorn Fierstra

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Muscas, G., van Niftrik, C.H.B., Sebök, M., Puppa, A.D., Regli, L., Fierstra, J. (2022). Recent Advances and Future Directions: Clinical Applications of Intraoperative BOLD-MRI CVR. In: Chen, J., Fierstra, J. (eds) Cerebrovascular Reactivity. Neuromethods, vol 175. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1763-2_11

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  • DOI: https://doi.org/10.1007/978-1-0716-1763-2_11

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1762-5

  • Online ISBN: 978-1-0716-1763-2

  • eBook Packages: Springer Protocols

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