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Pathophysiology of Grey Matter Affection in MS

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Translational Methods for Multiple Sclerosis Research

Part of the book series: Neuromethods ((NM,volume 166))

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Abstract

There is a striking relationship between cognitive performance, such as executive function, attention and motor processing, and grey matter (GM) surface- and voxel-based morphometric measures, as derived from magnetic resonance imaging (MRI). In addition, loss of GM has shown to be a reliable index of atrophy in neurological diseases, including multiple sclerosis (MS). Therefore, morphometric measures are highly valuable tools to noninvasively study brain pathology.

Among different MRI morphometric measures, cortical thinning has gained great importance for characterizing neurodegeneration in MS . While measures of dendrite density and myelin content assess further processes of GM pathology . Hence, MRI is a unique and versatile, noninvasive method for computer-aided lesion detection and brain-wide evaluation of the pathogenic neurodegenerative process in MS .

This chapter provides an overview of quantitative image analysis methods used to investigate GM pathology in MS and how to derive them, while describing the potential of inferring microstructural changes based on the microscopic and mesoscopic measurements obtained from MRI acquisitions.

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Authors and Affiliations

  1. Movement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany

    Gabriel Gonzalez-Escamilla & Dumitru Ciolac

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  1. Gabriel Gonzalez-Escamilla
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  2. Dumitru Ciolac
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Correspondence to Gabriel Gonzalez-Escamilla .

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Editors and Affiliations

  1. Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany

    Sergiu Groppa

  2. Department of Neurology, University of Düsseldorf, Düsseldorf, Germany

    Sven G. Meuth

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Gonzalez-Escamilla, G., Ciolac, D. (2021). Pathophysiology of Grey Matter Affection in MS. In: Groppa, S., G. Meuth, S. (eds) Translational Methods for Multiple Sclerosis Research. Neuromethods, vol 166. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1213-2_4

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  • DOI: https://doi.org/10.1007/978-1-0716-1213-2_4

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