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Functional Studies in Rodents

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Translational Methods for Multiple Sclerosis Research

Part of the book series: Neuromethods ((NM,volume 166))

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Abstract

Anatomical MRI is well established in the diagnosis of MS in humans and in rodent models. In contrast, functional MRI is not routinely established in rodent models of MS. In this chapter, we introduce the major MRI methods and analysis approaches used to study brain function in healthy animals and in neuropathological disease models. We highlight differences in relation to human MRI, for example the hardware requirements for rodent MRI, and the specific issues associated with the need for anesthesia, regarding animal physiology and monitoring.

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Author information

Authors and Affiliations

  1. Translational Imaging Center TRIC, Department of Clinical Radiology, University of Münster and University Hospital Münster, Münster, Germany

    Lydia Wachsmuth & Cornelius Faber

Authors
  1. Lydia Wachsmuth
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  2. Cornelius Faber
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Corresponding author

Correspondence to Lydia Wachsmuth .

Editor information

Editors and Affiliations

  1. Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany

    Sergiu Groppa

  2. Department of Neurology, University of Düsseldorf, Düsseldorf, Germany

    Sven G. Meuth

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Wachsmuth, L., Faber, C. (2021). Functional Studies in Rodents. In: Groppa, S., G. Meuth, S. (eds) Translational Methods for Multiple Sclerosis Research. Neuromethods, vol 166. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1213-2_16

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  • DOI: https://doi.org/10.1007/978-1-0716-1213-2_16

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1212-5

  • Online ISBN: 978-1-0716-1213-2

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