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Mechanisms and Regulation of Neuronal GABAB Receptor-Dependent Signaling

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Behavioral Neurobiology of GABAB Receptor Function

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 52))

Abstract

γ-Aminobutyric acid B receptors (GABABRs) are broadly expressed throughout the central nervous system where they play an important role in regulating neuronal excitability and synaptic transmission. GABABRs are G protein-coupled receptors that mediate slow and sustained inhibitory actions via modulation of several downstream effector enzymes and ion channels. GABABRs are obligate heterodimers that associate with diverse arrays of proteins to form modular complexes that carry out distinct physiological functions. GABABR-dependent signaling is fine-tuned and regulated through a multitude of mechanisms that are relevant to physiological and pathophysiological states. This review summarizes the current knowledge on GABABR signal transduction and discusses key factors that influence the strength and sensitivity of GABABR-dependent signaling in neurons.

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  1. Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA

    Timothy R. Rose & Kevin Wickman

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    Styliani Vlachou

  2. Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA

    Kevin Wickman

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Rose, T.R., Wickman, K. (2020). Mechanisms and Regulation of Neuronal GABAB Receptor-Dependent Signaling. In: Vlachou, S., Wickman, K. (eds) Behavioral Neurobiology of GABAB Receptor Function. Current Topics in Behavioral Neurosciences, vol 52. Springer, Cham. https://doi.org/10.1007/7854_2020_129

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