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Heat Shock Proteins: Central Players in Oncological and Immuno-Oncological Tracks

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Cell Biology and Translational Medicine, Volume 18

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1409))

Abstract

Heat shock proteins (HSPs) are a group of proteins that promote protein folding, inhibit denaturation of cellular proteins, and maintain other proteins’ functional activities when cells are subjected to stress and/or high temperature. HSP classification is generally based on their molecular weights into large and small HSP. The family of small HSPs includes HSPs 27, 40, 60, 70, and 90. The potential roles of HSP27 and HSP70 are quite evident in different solid malignancies, including breast, colorectal, pancreatic, and liver cancers. In this chapter, the authors focus on HSP27 and HSP70 signaling in oncology and their role in different solid malignancies as well as they shed light on the novel role of HSP70 and HSP90 in the immune-oncology field.

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Abbreviations

AAD:

Apoptosis activation domain

AIF:

Apoptosis-inducing factor

Apaf-1 :

Apoptotic protease-activating factor 1

APC:

Antigen-presenting cells

Ask1:

Apoptosis signal-regulating kinase 1

BID:

BH3 interacting-domain death agonist

BT-474:

Human breast tumor cell line

CARD:

Caspase-recruitment domain

CDK4:

Cyclin-dependent kinase 4

Clever:

Common lymphatic endothelial and vascular endothelial receptor

CRC:

Colorectal cancer

Daxx:

Death domain-associated protein 6

DEN:

Diethylnitrosamine

DR:

Death receptor

EMT:

Epithelial to mesenchymal transition

ER:

Endoplasmic reticulum

FADD:

Fas-associated death domain

FBD:

Fas binding domain

GADD153:

Growth arrest and DNA damage-inducible gene 153

GRP:

Glucose-related protein

HCC:

Hepatocellular carcinoma

HER-2:

Human epidermal growth factor 2

HSF:

Heat shock factor

HSP:

Heat shock protein

HUGO:

Human genome organisation

JNK:

C-Jun N-terminal kinase

LOX-1:

Low-density lipoprotein receptor-1

MDS:

Myelodysplastic syndrome

MHC:

Major histocompatibility complex

NY-ESO-1:

New York-esophageal

PES:

Phenylethynesulfonamide

PHC:

Primary hepatocellular carcinoma

PKC:

Protein kinase C

PTEN:

Phosphatase and tensin homolog

SPAG9:

Sperm-associated antigen 9 protein

SREC-1:

Scavenger receptor expressed by endothelial cell 1

SUMO:

Small ubiquitin-like modifier

TNF:

Tumor necrosis factor

VEGF:

Vascular endothelial growth factor

WT:

Wild type

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Acknowledgments

Not available.

Conflict of Interest

All authors declare they have no conflict of interest.

Ethical Approval for Studies Involving Humans

This article does not contain any studies with human participants performed by any of the authors.

Ethical Approval for Studies Involving Animals

This article does not contain any studies with animals performed by any of the authors.

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Author notes

  1. Authors ‘Rana A. Youness’ and ‘Asmaa Gohar’ have equally contributed to the manuscript

Authors and Affiliations

  1. Biology and Biochemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo, Egypt

    Rana A. Youness

  2. Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University, Cairo, Egypt

    Rana A. Youness & Caroline Joseph Kiriacos

  3. Extract and Allergen Evaluation Lab, Central Adminstration of Biological, Innovation Products and Clinical Studies, Egypt Drug Authority, Cairo, Egypt

    Asmaa Gohar

  4. Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University, Cairo, Egypt

    Mohamed El-Shazly

  5. Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt

    Mohamed El-Shazly

Authors
  1. Rana A. Youness
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  2. Asmaa Gohar
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  3. Caroline Joseph Kiriacos
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  4. Mohamed El-Shazly
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Corresponding authors

Correspondence to Rana A. Youness or Mohamed El-Shazly .

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Editors and Affiliations

  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Youness, R.A., Gohar, A., Kiriacos, C.J., El-Shazly, M. (2022). Heat Shock Proteins: Central Players in Oncological and Immuno-Oncological Tracks. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 18. Advances in Experimental Medicine and Biology(), vol 1409. Springer, Cham. https://doi.org/10.1007/5584_2022_736

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