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Optimal Delivery Route of Mesenchymal Stem Cells for Cardiac Repair: The Path to Good Clinical Practice

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Advances in Mesenchymal Stem Cells and Tissue Engineering (ICRRM 2023)

Part of the book series: Advances in Experimental Medicine and Biology ((ICRRM))

Abstract

Research has shown that mesenchymal stem cells (MSCs) could be a promising therapy for treating progressive heart disease. However, translation into clinics efficiently and successfully has proven to be much more complicated. Many questions remain for optimizing treatment. Application method influences destiny of MSCs and afterwards impacts results of procedure, yet there is no general agreement about most suitable method of MSC delivery in the clinical setting. Herein, we explain principle of most-frequent MSCs delivery techniques in cardiology. This chapter summarizes crucial translational obstacles of clinical employment of MSCs for cardiac repair when analysed trough a prism of latest research centred on different techniques of MSCs application.

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Abbreviations

AICI:

Antegrade intracoronary infusion

AICI:

antegrade intracoronary infusion

AMI:

acute myocardial infarction

AT-MSCs:

adipose tissue–derived mesenchymal stem cells

bFGF:

basic fibroblast growth factor

BM-MSCs:

bone marrow–derived mesenchymal stem/stromal cells

CABG:

coronary artery bypass grafting

CCR2:

chemokine receptor type-2 surface receptors

CROs:

contract research organizations

CVDs:

Cardiovascular diseases;

CXCR2:

C–X–C chemokine receptor type 2

CXCR-4:

C–X–C chemokine receptor type 4

DI:

direct implantation

EPCs:

endogenous endothelial regenerative progenitor cells

EPCs:

endogenous endothelial regenerative progenitor cells GCP-good clinical practice

ET-1:

endothelin-1

GM-CSF:

Granulocyte-macrophage colony-stimulating factor

HF:

heart failure

HGF:

hepatocyte growth factor

HO-1:

heme oxygenase-1

IA:

intra-arterial infusion

IC:

intracoronary

IC:

ischemic cardiomyopathy

IDO:

indoleamine 2,3-dioxygenase

IGF:

insulin-like growth factor

IHD:

ischemic heart disease

IL-10:

interleukin-10

IM:

intramyocardial

iNOS:

inducible nitric oxide synthase

IV:

intravenous

LIF:

leukaemia inhibitory factor

LVAD:

left ventricular assist device

LVEF:

left ventricle ejection fraction

LVF:

left ventricular function

MCP-1:

monocyte chemoattractant protein 1

MHC:

the major histocompatibility complex

MMP-9:

Matrix metallopeptidase 9

MSCs:

mesenchymal stem cells

NICM:

non-ischemic cardiomyopathy

PCI:

percutaneous transluminal coronary intervention

PDGF:

Platelet-derived growth factor

PGE2:

prostaglandin E2

RCVI:

retrograde coronary venous infusion

SDF1:

stromal cell–derived factor 1

TE:

transendocardial

TESI:

transendocardial stem cell injection

TGF-β:

transforming growth factor-β

UC-MSC:

Umbilical cord–derived mesenchymal stem cells

VEGF:

Vascular endothelial growth factor

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Acknowledgements

This study was supported by Serbian Ministry of Sciences (project number ON 175103) and Faculty of Medical Sciences University of Kragujevac (JP 05/20).

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  1. Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, Kragujevac, Serbia

    Dragica Miloradovic, Dragana Miloradovic, Biljana Ljujic & Marina Gazdic Jankovic

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  1. Dragica Miloradovic
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  2. Dragana Miloradovic
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  3. Biljana Ljujic
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  4. Marina Gazdic Jankovic
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Correspondence to Marina Gazdic Jankovic .

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  1. Stem Cells Institute, University of Science Viet Nam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Miloradovic, D., Miloradovic, D., Ljujic, B., Jankovic, M.G. (2022). Optimal Delivery Route of Mesenchymal Stem Cells for Cardiac Repair: The Path to Good Clinical Practice. In: Pham, P.V. (eds) Advances in Mesenchymal Stem Cells and Tissue Engineering. ICRRM 2023. Advances in Experimental Medicine and Biology(). Springer, Cham. https://doi.org/10.1007/5584_2022_709

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