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Tissue Engineering for Tracheal Replacement: Strategies and Challenges

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Advances in Mesenchymal Stem Cells and Tissue Engineering (ICRRM 2023)

Part of the book series: Advances in Experimental Medicine and Biology ((ICRRM))

Abstract

The critical feature in trachea replacement is to provide a hollow cylindrical framework that is laterally stable and longitudinally flexible, facilitating cartilage and epithelial tissue formation. Despite advanced techniques and sources of materials used, most inherent challenges are related to the complexity of its anatomy. Limited blood supply leads to insufficient regenerative capacity for cartilage and epithelium. Natural and synthetic scaffolds, different types of cells, and growth factors are part of tissue engineering approaches with varying outcomes. Pre-vascularization remains one of the crucial factors to expedite the regenerative process in tracheal reconstruction. This review discusses the challenges and strategies used in tracheal tissue engineering, focusing on scaffold implantation in clinical and preclinical studies conducted in recent decades.

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Acknowledgement

This research was funded by the Ministry of Higher Education, Malaysia, for the Prototype Research Grant Scheme (PRGS) with Project Code PRGS/1/2021/SKK07/USM/02/1 and Universiti Sains Malaysia (USM) Research University Grant (1001/CIPPT/8012203). Additionally, the author would like to thank the Ministry of Higher Education and the International Islamic University, Malaysia, for their support through the Academic Staff Training Scheme fellowship (ASTS) for Asmak Abdul Samat.

Conflict of Interest

All authors declare no conflict of interest. The authors alone are responsible for the content and writing of the article.

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Authors and Affiliations

  1. Lung Stem Cell and Gene Therapy Group, Regenerative Medicine Cluster, Advanced Medical and Dental Institute (IPPT), Universiti Sains Malaysia, Penang, Malaysia

    Asmak Abdul Samat & Badrul Hisham Yahaya

  2. Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, Malaysia

    Asmak Abdul Samat

  3. School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Penang, Malaysia

    Zuratul Ain Abdul Hamid

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  1. Stem Cells Institute, University of Science Viet Nam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Samat, A.A., Hamid, Z.A.A., Mariatti Jaafar @ Mustapha., Yahaya, B.H. (2022). Tissue Engineering for Tracheal Replacement: Strategies and Challenges. In: Pham, P.V. (eds) Advances in Mesenchymal Stem Cells and Tissue Engineering. ICRRM 2023. Advances in Experimental Medicine and Biology(). Springer, Cham. https://doi.org/10.1007/5584_2022_707

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