Abstract
Primary tracheal tumors are sporadic and represent 0.1% of all malignancy. The low index of suspicion and nonspecific symptoms often result in diagnostic delays. Surgery is the primary treatment with the optimal survival rates. Radiation can play a vital role in adjuvant, curative (unresectable), and palliative settings.
Lack of a standard staging system is a significant challenge, and the current state of primary tracheal cancer literature reflects a lack of a high level of evidence interventions. The management relies on available low-quality evidence, with databases lacking complete details and jeopardized by geographical bias. Using a standard staging system, creating a central/national level rare disease database, and rigorous data recording would help overcome some of the current shortcomings. Managing these rare tumors in experienced centers with multidisciplinary expertise is recommended.
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References
Aboudara M, Rickman O, Maldonado F (2020) Therapeutic bronchoscopic techniques available to the pulmonologist: emerging therapies in the treatment of peripheral lung lesions and endobronchial tumors. Clin Chest Med 41:145–160
Agrawal S, Jackson C, Celie KB et al (2017) Survival trends in patients with tracheal carcinoma from 1973 to 2011. Am J Otolaryngol 38:673–677
Allen AM, Rabin MS, Reilly JJ et al (2007) Unresectable adenoid cystic carcinoma of the trachea treated with chemoradiation. J Clin Oncol 25:5521–5523
American College of Chest Physicians, Health and Science Policy Committee (2003) Diagnosis and management of lung cancer: ACCP evidence-based guidelines. American College of Chest Physicians. Chest 123:D–G, 1S–337S
Azar T, Abdul-Karim FW, Tucker HM (1998) Adenoid cystic carcinoma of the trachea. Laryngoscope 108:1297–1300
Barnes D, Gutierrez Chacoff J, Benegas M et al (2017) Central airway pathology: clinic features, CT findings with pathologic and virtual endoscopy correlation. Insights Imaging 8:255–270
Benissan-Messan DZ, Merritt RE, Bazan JG et al (2020) National utilization of surgery and outcomes for primary tracheal cancer in the United States. Ann Thorac Surg 110:1012–1022
Bhattacharyya N (2004) Contemporary staging and prognosis for primary tracheal malignancies: a population-based analysis. Otolaryngol Head Neck Surg 131:639–642
Bolliger CT, Mathur PN, Beamis JF et al (2002) ERS/ATS statement on interventional pulmonology. European Respiratory Society/American Thoracic Society. Eur Respir J 19:356–373
Chao MW, Smith JG, Laidlaw C et al (1998) Results of treating primary tumors of the trachea with radiotherapy. Int J Radiat Oncol Biol Phys 41:779–785
Chow DC, Komaki R, Libshitz HI et al (1993) Treatment of primary neoplasms of the trachea. The role of radiation therapy. Cancer 71:2946–2952
Diaz-Mendoza J, Debiane L, Peralta AR et al (2019) Tracheal tumors. Curr Opin Pulm Med 25:336–343
Ernst A, Silvestri GA, Johnstone D et al (2003) Interventional pulmonary procedures: guidelines from the American College of Chest Physicians. Chest 123:1693–1717
Fiorentino A, Gregucci F, Desideri I et al (2021) Radiation treatment for adult rare cancers: oldest and newest indication. Crit Rev Oncol Hematol 159:103228
Gale N, Poljak M, Zidar N (2017) Update from the 4th edition of the World Health Organization classification of head and neck tumours: what is new in the 2017 WHO blue book for tumours of the hypopharynx, larynx, trachea and parapharyngeal space. Head Neck Pathol 11:23–32
Grillo HC (1990) Primary tracheal tumors: treatment and results. Ann Thorac Surg 49:69–77
Guibert N, Mhanna L, Droneau S et al (2016) Techniques of endoscopic airway tumor treatment. J Thorac Dis 8:3343–3360
Han S, El-Abbadi NH, Hanna N et al (2005) Evaluation of tracheal imaging by optical coherence tomography. Respiration 72:537–541
Hararah MK, Stokes WA, Oweida A et al (2020) Epidemiology and treatment trends for primary tracheal squamous cell carcinoma. Laryngoscope 130:405–412
Harms W, Latz D, Becker H et al (1999) HDR-brachytherapy boost for residual tumour after external beam radiotherapy in patients with tracheal malignancies. Radiother Oncol 52:251–255
Harms W, Latz D, Becker H et al (2000) Treatment of primary tracheal carcinoma. The role of external and endoluminal radiotherapy. Strahlenther Onkol 176:22–27
He J, Shen J, Huang J et al (2017) Prognosis of primary tracheal tumor: a population-based analysis. J Surg Oncol 115:1004–1010
Honings J, van Dijck JA, Verhagen AF et al (2007) Incidence and treatment of tracheal cancer: a nationwide study in the Netherlands. Ann Surg Oncol 14:968–976
Honings J, Gaissert HA, Ruangchira-Urai R et al (2009a) Pathologic characteristics of resected squamous cell carcinoma of the trachea: prognostic factors based on an analysis of 59 cases. Virchows Arch 455:423–429
Honings J, Gaissert HA, Verhagen AF et al (2009b) Undertreatment of tracheal carcinoma: multidisciplinary audit of epidemiologic data. Ann Surg Oncol 16:246–253
Honings J, Gaissert HA, Weinberg AC et al (2010) Prognostic value of pathologic characteristics and resection margins in tracheal adenoid cystic carcinoma. Eur J Cardiothorac Surg 37:1438–1444
Jamjoom L, Obusez EC, Kirsch J et al (2014) Computed tomography correlation of airway disease with bronchoscopy—part II: tracheal neoplasms. Curr Probl Diagn Radiol 43:278–284
Javidan-Nejad C (2010) MDCT of trachea and main bronchi. Radiol Clin North Am 48:157–176
Je HU, Song SY, Kim DK et al (2017) A 10-year clinical outcome of radiotherapy as an adjuvant or definitive treatment for primary tracheal adenoid cystic carcinoma. Radiat Oncol 12:196
Jeong SY, Lee KS, Han J et al (2007) Integrated PET/CT of salivary gland type carcinoma of the lung in 12 patients. AJR Am J Roentgenol 189:1407–1413
Jeremic B, Shibamoto Y, Acimovic L et al (1996) Radiotherapy for primary squamous cell carcinoma of the trachea. Radiother Oncol 41:135–138
Kurimoto N, Murayama M, Yoshioka S et al (1999) Assessment of usefulness of endobronchial ultrasonography in determination of depth of tracheobronchial tumor invasion. Chest 115:1500–1506
Levy A, Omeiri A, Fadel E et al (2018) Radiotherapy for tracheal-bronchial cystic adenoid carcinomas. Clin Oncol (R Coll Radiol) 30:39–46
Licht PB, Friis S, Pettersson G (2001) Tracheal cancer in Denmark: a nationwide study. Eur J Cardiothorac Surg 19:339–345
Macchiarini P (2006) Primary tracheal tumours. Lancet Oncol 7:83–91
Madariaga MLL, Gaissert HA (2018) Overview of malignant tracheal tumors. Ann Cardiothorac Surg 7:244–254
Makarewicz R, Mross M (1998) Radiation therapy alone in the treatment of tumours of the trachea. Lung Cancer 20:169–174
Mallick S, Benson R, Giridhar P et al (2019) Demography, patterns of care and survival outcomes in patients with malignant tumors of trachea: a systematic review and individual patient data analysis of 733 patients. Lung Cancer 132:87–93
Manninen MP, Antila PJ, Pukander JS et al (1991) Occurrence of tracheal carcinoma in Finland. Acta Otolaryngol 111:1162–1169
Maziak DE, Todd TR, Keshavjee SH et al (1996) Adenoid cystic carcinoma of the airway: thirty-two-year experience. J Thorac Cardiovasc Surg 112:1522–1531; discussion 1531–1532
McInnis MC, Weisbrod G, Schmidt H (2018) Advanced technologies for imaging and visualization of the tracheobronchial tree: from computed tomography and MRI to virtual endoscopy. Thorac Surg Clin 28:127–137
Meyers BF, Mathisen DJ (1997) Management of tracheal neoplasms. Oncologist 2:245–253
Mornex F, Coquard R, Danhier S et al (1998) Role of radiation therapy in the treatment of primary tracheal carcinoma. Int J Radiat Oncol Biol Phys 41:299–305
Napieralska A, Miszczyk L, Blamek S (2016) Tracheal cancer - treatment results, prognostic factors and incidence of other neoplasms. Radiol Oncol 50:409–417
Ogino T, Ono R, Shimizu W et al (1995) Adenoid cystic carcinoma of the tracheobronchial system: the role of postoperative radiotherapy. Radiat Med 13:27–29
Park CM, Goo JM, Lee HJ et al (2009) Tumors in the tracheobronchial tree: CT and FDG PET features. Radiographics 29:55–71
Parrish RW, Banks J, Fennerty AG (1983) Tracheal obstruction presenting as asthma. Postgrad Med J 59(698):775–776
Ran J, Qu G, Chen X et al (2021) Clinical features, treatment and outcomes in patients with tracheal adenoid cystic carcinoma: a systematic literature review. Radiat Oncol 16:38
Regnard JF, Fourquier P, Levasseur P (1996) Results and prognostic factors in resections of primary tracheal tumors: a multicenter retrospective study. The French Society of Cardiovascular Surgery. J Thorac Cardiovasc Surg 111:808–813; discussion 813–814
Rostom AY, Morgan RL (1978) Results of treating primary tumours of the trachea by irradiation. Thorax 33:387–393
Shadmehr MB, Farzanegan R, Graili P et al (2011) Primary major airway tumors; management and results. Eur J Cardiothorac Surg 39:749–754
Sharifnia T, Hong AL, Painter CA et al (2017) Emerging opportunities for target discovery in rare cancers. Cell Chem Biol 24:1075–1091
Shepard JO, Flores EJ, Abbott GF (2018) Imaging of the trachea. Ann Cardiothorac Surg 7:197–209
Urdaneta AI, Yu JB, Wilson LD (2011) Population based cancer registry analysis of primary tracheal carcinoma. Am J Clin Oncol 34:32–37
Waki A, Kato H, Yano R et al (1998) The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumor cells in vitro. Nucl Med Biol 25:593–597
Webb BD, Walsh GL, Roberts DB et al. (2006) Primary tracheal malignant neoplasms: the University of Texas MD Anderson Cancer Center experience. J Am Coll Surg 202:237–46. https://doi.org/10.1016/j.jamcollsurg.2005.09.016. Epub 2005 Nov 21. PMID: 16427548
Weber AL, Shortsleeve M, Goodman M et al (1978) Cartilaginous tumors of the larynx and trachea. Radiol Clin North Am 16:261–267
Wood DE (2001) Bronchoscopic preparation for airway resection. Chest Surg Clin N Am 11:735–748
Wood DE (2002) Management of malignant tracheobronchial obstruction. Surg Clin North Am 82:621–642
Xie L, Fan M, Sheets NC et al (2012) The use of radiation therapy appears to improve outcome in patients with malignant primary tracheal tumors: a SEER-based analysis. Int J Radiat Oncol Biol Phys 84:464–470
Yang KY, Chen YM, Huang MH et al (1997) Revisit of primary malignant neoplasms of the trachea: clinical characteristics and survival analysis. Jpn J Clin Oncol 27:305–309
Yang CJ, Shah SA, Ramakrishnan D et al (2020) Impact of positive margins and radiation after tracheal adenoid cystic carcinoma resection on survival. Ann Thorac Surg 109:1026–1032
Yusuf M, Gaskins J, Trawick E et al (2019) Effects of adjuvant radiation therapy on survival for patients with resected primary tracheal carcinoma: an analysis of the National Cancer Database. Jpn J Clin Oncol 49:628–638
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Rathod, S. (2023). Primary Tracheal Tumors. In: Jeremić, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2022_334
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DOI: https://doi.org/10.1007/174_2022_334
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