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SLC26 Anion Transporters

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Anion Channels and Transporters

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 283))

Abstract

Solute carrier family 26 (SLC26) is a family of functionally diverse anion transporters found in all kingdoms of life. Anions transported by SLC26 proteins include chloride, bicarbonate, and sulfate, but also small organic dicarboxylates such as fumarate and oxalate. The human genome encodes ten functional homologs, several of which are causally associated with severe human diseases, highlighting their physiological importance. Here, we review novel insights into the structure and function of SLC26 proteins and summarize the physiological relevance of human members.

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Acknowledgments

Work in laboratories of ERG and DO is supported by the Deutsche Forschungsgemeinschaft (DFG; Research Unit FOR 5046; GE 2841/2-1 and GE 2841/3-1 to ERG; OL 240/8-1 and OL240/9-1 to DO).

We thank Ursula Seidler and Benedikt Kuhn for critically reading the manuscript.

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Authors and Affiliations

  1. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

    Eric R. Geertsma

  2. Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University Marburg, Marburg, Germany

    Dominik Oliver

  3. Center for Mind, Brain and Behavior (CMBB), Universities of Marburg and Giessen, Marburg, Giessen, Germany

    Dominik Oliver

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  1. Eric R. Geertsma
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Correspondence to Eric R. Geertsma or Dominik Oliver .

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  1. Institute of Biological Information Processing Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Nordrhein-Westfalen, Germany

    Christoph Fahlke

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Geertsma, E.R., Oliver, D. (2023). SLC26 Anion Transporters. In: Fahlke, C. (eds) Anion Channels and Transporters. Handbook of Experimental Pharmacology, vol 283. Springer, Cham. https://doi.org/10.1007/164_2023_698

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