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Activity Dependent Regulation of the Cl− Transporting System in Neurons

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Synaptic Plasticity and Transsynaptic Signaling

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4. Conclusion

Mounting evidence suggests that regulation of the neuronal Cl− transport capacity contributes to the plasticity of Cl− dependent postsynaptic inhibition in the brain. Shifts of [Cl−]i in neurons allow synaptic tuning across a voltage domain that covers the range between the membrane potentials set by the other main ligand gated conductances, K+ conductance on the one hand and unspecific cation conductance on the other hand. So far the existing literature has allowed not much more but a glimpse at a network of regulating factors by which activity dependent signals could adjust KCC2 and, hence, [Cl−]i to changing demands for inhibition in neuronal networks. However, also irritating or deteriorating influences may lead to [Cl−]i elevations because of reduced KCC2 function and, hence, be reinforced by an impaired inhibition, thereby contributing to neuronal vulnerability.

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Authors and Affiliations

  1. Institute of Physiology and Pathophysiology and IZN, University of Heidelberg, D-69120, Heidelberg, Germany

    Stefan Titz & Ulrich Misgeld

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  1. Stefan Titz
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  2. Ulrich Misgeld
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Editors and Affiliations

  1. Department of Neurology, New York Medical College, Valhalla, NY, 10595, USA

    Patrick K. Stanton

  2. Department of Physiology, University of Bergen, Bergen, 5009, Norway

    Clive Bramham

  3. CNRRR Department, Helen Hayes Hospital, West Haverstraw, NY, 10993, USA

    Helen E. Scharfman

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Titz, S., Misgeld, U. (2005). Activity Dependent Regulation of the Cl− Transporting System in Neurons. In: Stanton, P.K., Bramham, C., Scharfman, H.E. (eds) Synaptic Plasticity and Transsynaptic Signaling. Springer, Boston, MA. https://doi.org/10.1007/0-387-25443-9_7

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