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An Efficient Approach for the Synthesis of Triazole Conjugated Pyrazole Chalcone Derivatives

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Abstract

An important intermediate, 3-(4-((1-benzyl-1H-1,2,3-triazol-5-yl)methoxy)-2-hydroxy phenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde in the synthesis of target compounds was synthesized using 2,4-dihydroxyacetophenone as starting synthon by adopting two different click chemistry synthetic protocols. Later the intermediate was further converted into a new series of triazole conjugated pyrazole chalcones from various acetophenones in the presence of potassium hydroxide under microwave irradiation and conventional methods.

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Acknowledgements

The authors are thankful to Jawaharlal Nehru Technological University Hyderabad for providing laboratory facilities and CFRD, Osmania University, Hyderabad for analytical facilities.

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Authors and Affiliations

  1. Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Hyderabad, 500 085, India

    Venkataramana Rupireddy & Venkata Ramana Reddy Chittireddy

  2. Department of Chemistry, Osmania University, Hyderabad, Telangana, 500 007, India

    Ashok Dongamanti

Authors
  1. Venkataramana Rupireddy
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  2. Venkata Ramana Reddy Chittireddy
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  3. Ashok Dongamanti
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Corresponding author

Correspondence to Venkata Ramana Reddy Chittireddy.

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Rupireddy, V., Chittireddy, V.R.R. & Dongamanti, A. An Efficient Approach for the Synthesis of Triazole Conjugated Pyrazole Chalcone Derivatives. Chemistry Africa 3, 45–52 (2020). https://doi.org/10.1007/s42250-019-00103-9

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