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Spatio-Temporal Control of Cellular and Organismal Physiology by Sirtuins

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Journal of the Indian Institute of Science Aims and scope

Abstract

The survival of an organism is intricately dependent upon its ability to sense and respond to both extracellular and intracellular cues. In the context of metabolic or nutrient sensing while intracellular signaling ensures synchronization of various metabolic pathways, inter-tissue communication enables the organism to couple energetic needs of all the organ systems and in a concerted manner. In this review, we highlight the role of evolutionarily conserved sirtuins (NAD-dependent deacylases) in synchronizing inter-organellar and inter-tissue cross-talk that is needed to orchestrate organism-wide metabolic homeostasis.

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    Authors and Affiliations

    1. Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, 400005, India

      Shaunak Deota, Namrata Shukla & Ullas Kolthur-Seetharam

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    1. Shaunak Deota
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    2. Namrata Shukla
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    3. Ullas Kolthur-Seetharam
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    Correspondence to Ullas Kolthur-Seetharam.

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    S. Deota and N. Shukla contributed equally.

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    Deota, S., Shukla, N. & Kolthur-Seetharam, U. Spatio-Temporal Control of Cellular and Organismal Physiology by Sirtuins. J Indian Inst Sci 97, 147–159 (2017). https://doi.org/10.1007/s41745-016-0018-9

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