Abstract
The local tumor hypoxia has become one of the main obstacles for photodynamic therapy (PDT).To break through this barrier, the fabrication of O2-evolving nanoplatform has been more significant. Herein, the uniform methylene blue (MB)–bovine serum albumin (BSA)–Fe(III) nanoparticles (MB–BSA–Fe(III) NPs) were successfully synthesized by biomineralization approach. MB–BSA–Fe(III) NPs show high loading capacity of MB, and Fe(ΙΙΙ) has excellent catalytic performance towards abundant H2O2 in cancer cells to generate O2, overcoming tumor hypoxia. All these combination effects remarkably increase the therapeutic efficiency of PDT, resulting in almost complete destruction of cancer cells. Most importantly, MB–BSA–Fe(III) NPs exhibit T2- magnetic resonance imaging, which have the potential for precise visualization of the tumor location. Our results demonstrate that MB–BSA–Fe(III) is a novel H2O2-responsive and O2-evolving nanoplatform and it has great potential for clinical applications such as cancer diagnosis, treatment or drug delivery.
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Acknowledgements
This work was financially supported by the National Natural Science Foundation of China (21675149, 21505130, 21705146), the Science and Technology Development Program of Jilin Province (20150519014JH, 20170414037GH, 20170520133JH), and the Key Research Program of Frontier Sciences, CAS (QYZDY-SSW-SLH019).
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Zhen, WY., Bai, J., Jia, XD. et al. H2O2-Responsive MB–BSA–Fe(III) Nanoparticles as Oxygen Generators for MRI-Guided Photodynamic Therapy. J. Anal. Test. 2, 69–76 (2018). https://doi.org/10.1007/s41664-018-0050-z
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DOI: https://doi.org/10.1007/s41664-018-0050-z